Kevin Truong
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View article: Nearby and non-nested genes in the human genome have more similar genotype tissue expression
Nearby and non-nested genes in the human genome have more similar genotype tissue expression Open
Neighboring genes within a shared promoter arrangement (i.e. opposite direction with the neighboring ends as the transcriptional start sites) are expected to have a high similarity in genotype tissue expression due to the potential overlap…
View article: Design of a synthesis‐friendly hypoxia‐responsive promoter for cell‐based therapeutics
Design of a synthesis‐friendly hypoxia‐responsive promoter for cell‐based therapeutics Open
Towards the goal of making ‘smart’ cell therapies, one that recognizes disease conditions (e.g. hypoxia) and then produces mitigating biologics, it is important to develop suitable promoters. Currently, hypoxia responsive promoters are com…
View article: Creation of a synthesis-friendly inflammation-inducible promoter suitable for cell therapy
Creation of a synthesis-friendly inflammation-inducible promoter suitable for cell therapy Open
The development of ‘smart’ cell-based therapeutics requires cells that first recognize conditions consistent with disease (e.g. inflammation) and then subsequently release therapeutic proteins, thereby reducing potential toxicity from othe…
View article: EPEN-05. MUTATIONAL ANALYSIS OF THE C11ORF95 DOMAIN AND SINGLE-CELL RNA-SEQ PROFILE OF A MOUSE MODEL OF SUPRATENTORIAL EPENDYMOMA
EPEN-05. MUTATIONAL ANALYSIS OF THE C11ORF95 DOMAIN AND SINGLE-CELL RNA-SEQ PROFILE OF A MOUSE MODEL OF SUPRATENTORIAL EPENDYMOMA Open
We used a recently developed mouse model to better understand the cellular and molecular determinants of tumors driven by the oncogenic fusion protein C11orf95-RELA. Our approach makes use of in utero electroporation and a binary transposa…
View article: Replication initiation and elongation fork rates within a differentially expressed human multicopy locus in early S phase
Replication initiation and elongation fork rates within a differentially expressed human multicopy locus in early S phase Open
Replication of the 400 copies of the 43 kb human ribosomal RNA (rDNA) locus spans most of the S phase. To examine the basis for the unusual pattern of rDNA replication, a sensitive strategy was developed to map origins of DNA replication a…
View article: Light directed migration of a cluster of cells in the centimeter scale
Light directed migration of a cluster of cells in the centimeter scale Open
Protein-based systems for light directed migration of cells have been demonstrated up to distances of several hundred microns, but larger distances in the centimeter scale would allow new possible applications. Light activated migration in…
View article: Engineering a temperature sensitive tobacco etch virus protease
Engineering a temperature sensitive tobacco etch virus protease Open
Since tobacco etch virus protease (TEVp) has a high specificity and efficiency in cleaving its target substrates, many groups have attempted to engineer conditional control of its activity. Temperature induction is widely used for modulati…
View article: Engineering mammalian cells to seek senescence-associated secretory phenotypes
Engineering mammalian cells to seek senescence-associated secretory phenotypes Open
Since the removal of senescent cells in model organisms has been linked to rejuvenation and increased lifespan, senotherapies have emerged to target senescent cells for death. In particular, interleukin-6 (IL6) is a prominent senescence-as…
View article: An Engineered Split Intein for Photoactivated Protein Trans-Splicing
An Engineered Split Intein for Photoactivated Protein Trans-Splicing Open
Protein splicing is mediated by inteins that auto-catalytically join two separated protein fragments with a peptide bond. Here we engineered a genetically encoded synthetic photoactivatable intein (named LOVInC), by using the light-sensiti…