Kévin Van Dongen
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View article: Atheroma plaque microenvironment stimulates kynurenine production by macrophages to induce endothelial adhesion molecules in the context of atherogenesis
Atheroma plaque microenvironment stimulates kynurenine production by macrophages to induce endothelial adhesion molecules in the context of atherogenesis Open
Cardiovascular diseases, including atherosclerosis, are major causes of morbidity and mortality worldwide. Here, we investigate the role of the kynurenine pathway (KP) in macrophages in the context of atheroma plaque microenvironment and i…
View article: Regulation of glycolytic genes in human macrophages by oxysterols: a potential role for liver X receptors
Regulation of glycolytic genes in human macrophages by oxysterols: a potential role for liver X receptors Open
Background and Purpose Subset of macrophages within the atheroma plaque displays a high glucose uptake activity. Nevertheless, the molecular mechanisms and the pathophysiological significance of this high glucose need remain unclear. While…
View article: Inhibition of mitophagy drives macrophage activation and antibacterial defense during sepsis
Inhibition of mitophagy drives macrophage activation and antibacterial defense during sepsis Open
Mitochondria have emerged as key actors of innate and adaptive immunity. Mitophagy has a pivotal role in cell homeostasis, but its contribution to macrophage functions and host defense remains to be delineated. Here, we showed that lipopol…