Kevin Wickham
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View article: Quiescent cell re-entry is limited by macroautophagy-induced lysosomal damage
Quiescent cell re-entry is limited by macroautophagy-induced lysosomal damage Open
To maintain tissue homeostasis, many cells reside in a quiescent state until prompted to divide. The reactivation of quiescent cells is perturbed with aging and may underlie declining tissue homeostasis and resiliency. The unfolded protein…
View article: Quiescent cell re-entry is limited by macroautophagy-induced lysosomal damage
Quiescent cell re-entry is limited by macroautophagy-induced lysosomal damage Open
Summary To maintain tissue homeostasis, many cells are kept in a quiescent state until prompted to divide. The re-activation of quiescent cells is perturbed with aging and may underlie declining tissue homeostasis and resiliency. The unfol…
View article: Glia of <i>C. elegans</i> coordinate a protective organismal heat shock response independent of the neuronal thermosensory circuit
Glia of <i>C. elegans</i> coordinate a protective organismal heat shock response independent of the neuronal thermosensory circuit Open
Aging organisms lose the ability to induce stress responses, becoming vulnerable to protein toxicity and tissue damage. Neurons can signal to peripheral tissues to induce protective organelle-specific stress responses. Recent work shows th…