Explanipedia

Nuclear Actin Polymerization Regulates Cell Epithelial‐Mesenchymal Transition Open

William W. Du, Javeria Qadir, Kevin Y. Du, Yú Chen, Nan Wu , et al. · 2023

Current studies on actin function primarily rely on cytoplasmic actin due to the absence of cellular models specifically expressing nuclear actin. Here, cell models capable of expressing varying levels of nuclear F/G‐actin are generated an…

Tracking miR-17-5p Levels following Expression of Seven Reported Target mRNAs Open

Kevin Y. Du, Javeria Qadir, Burton B. Yang, Albert Yee, Weining Yang · 2022

As the most prominent member of the miR-17-92 cluster, miR-17-5p is well associated with tumorigenesis and cancer progression. It can exert both oncogenic and tumor-suppressive functions by inducing translational repression and/or mRNA dec…

Correction to: Incidence, clinical features, and outcomes of COVID-19 in Canada: Impact of sex and age Open

Jacob A. O’Brien, Kevin Y. Du, Chun Peng · 2021

Incidence, clinical features, and outcomes of COVID-19 in Canada: impact of sex and age Open

Jacob A. O’Brien, Kevin Y. Du, Chun Peng · 2020

Male sex and older age have been reported to be associated with worse outcomes from COVID-19. It was postulated that estrogens may play a role in reducing the severity of the disease and may therefore offer a treatment option for COVID-19 …

Incidence, clinical features, and outcomes of COVID-19 in Canada: Impact of sex and age Open

Jacob A. O’Brien, Kevin Y. Du, Chun Peng · 2020

Male sex and older age have been reported to be associated with worse outcomes from COVID-19. It was postulated that estrogens may play a role in reducing the severity of the disease and may therefore offer a treatment option for COVID-19 …

The Role of microRNAs in Epithelial Ovarian Cancer Metastasis Open

Vu H. Nguyen, Chenyang Yue, Kevin Y. Du, Mohamed A. Salem, Jacob A. O’Brien , et al. · 2020

Epithelial ovarian cancer (EOC) is the deadliest gynecological cancer, and the major cause of death is mainly attributed to metastasis. MicroRNAs (miRNAs) are a group of small non-coding RNAs that exert important regulatory functions in ma…

Translation of yes-associated protein (YAP) was antagonized by its circular RNA via suppressing the assembly of the translation initiation machinery Open

Nan Wu, Zhidong Yuan, Kevin Y. Du, Ling Fang, Juanjuan Lyu , et al. · 2019

Yap is the key component of Hippo pathway which plays crucial roles in tumorigenesis. Inhibition of Yap activity could promote apoptosis, suppress proliferation, and restrain metastasis of cancer cells. However, how Yap is regulated is not…

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