Explanipedia

3D genetic architecture of schizophrenia risk across three neuronal subtypes Open

Samuel K. Powell, Will Liao, Sadaf Ghorbani, Raymond Rigat, Sarah Kammourh , et al. · 2025

Common genetic variants associated with schizophrenia risk are concentrated in non-coding regulatory sequences, but their precise target genes are context-dependent and impacted by cell-type-specific three-dimensional spatial chromatin org…

Investigation of the Causes of Inflammatory Reaction after Arthroscopic Anterior Cruciate Ligament Reconstruction Open

Lifeng Wang, Wencang Jiao, Ke Wang, Lei Zhao, Shan-Liang Xie , et al. · 2025

Objective: To analyze the data of local inflammatory storm after anterior cruciate ligament reconstruction under knee arthroscopy, and to understand the causes and countermeasures. Methods: A retrospective analysis was performed on 135 pat…

An Ultrapotent, Ultraeconomical, Antifreeze Polypeptide Open

Thomas J. McPartlon, Charles T. Osborne, Ke Wang, Rachel E. Detwiler, Konrad Meister , et al. · 2025

The growth of large ice crystals during freeze and thaw events is a challenge in diverse settings from transportation and agriculture to foods and biomedicine. Design, synthesis, and evaluation of antifreeze polypeptides that inhibit ice c…

Modulation of Gut Microbiota Mediates the Anti-Inflammatory Effect of Chi-Ju-Di-Huang-Wan against Dry Eye Disease Open

Minal Thacker, Ka‐Ying Wong, Christina Chui‐Wa Poon, Wenjie Wu, Ke Wang , et al. · 2025

Objective: Chi-Ju-Di-Huang-Wan (CJDHW) is commonly prescribed for the treatment of dry eye disease (DED) with well-documented effectiveness. However, the underlying mechanism remains unclear. Our study aimed to elucidate its potential mech…

Investigating Zinc Migration from Rigid Needle Shield to Drug Formulation in Needle Tip of Pre-filled Syringe Open

Guangli Hu, Chunqian Li, Ke Wang, Yongchao Su, W. J. Forrest , et al. · 2025

Persistent Boryl Radicals as Highly Reducing Photoredox Catalysts for Debrominative Borylations Open

Jingjing Wu, Hui Wang, Huaquan Fang, Ke Wang, Deborin Ghosh , et al. · 2025

Organic free radicals are commonly perceived to be highly reactive species with short lifetimes, yet there are many examples that defy this convention by displaying remarkable stability. Although these persistent radicals can be relatively…

Development and application of a highly sensitive quadruple droplet digital PCR method for simultaneous quantification of sulfonamide resistance genes Open

Xirong Yin, Jiayuan Nie, Huifang Tian, Lihong Duan, Lixia Wu , et al. · 2025

Sulfonamide resistance genes ( sul genes) have a high detection rate and strong transmissibility. Therefore, there is an urgent need to develop more efficient detection methods to enhance the monitoring of sul genes. Current analytical met…

Genome-wide nucleosome footprints of plasma cfDNA predict preterm birth: A case-control study Open

Zhiwei Guo, Ke Wang, Xiang Huang, Kun Li, Guojun Ouyang , et al. · 2025

Background Preterm birth (PTB) occurs in approximately 11% of all births worldwide, resulting in significant morbidity and mortality for both mothers and their offspring. Identifying pregnancies at risk of preterm birth during early pregna…

PURPL Represses Radiation‐Induced Apoptosis to Promote Radioresistance in Cutaneous Melanoma by Direct Interfering With BID Cleavage Open

Xue Li, Shuo Han, Xiaoting Liang, Jieyu Liu, Ke Wang , et al. · 2025

The rise of radioresistance in treating cutaneous melanoma challenges the efficacy of radiotherapy. Transcriptomic sequencing highlights PURPL as one of the top upregulated long noncoding RNAs in response to ionizing radiation (IR) treatme…

A Facile Method for Reduction of Alkene and Dehalogenation Under Electrochemical Reduction Condition Open

Bing Wang, Ke Wang, Peixu Xie, Ru Yu Chen, Yanshan Lu , et al. · 2025

A facile and efficient electrochemical strategy for reduction of various aryl alkenes/alkynes to aryl alkyl derivatives was achieved. The protocol was also suitable to dehalogenation of structural versatile aryl/alkyl halides. This strateg…

The effect of comorbid anxiety and major depression on functional outcomes in meniscectomy Open

Yusuf N Mufti, Jared P. Sachs, David D. Christian, Ke Wang, Allen A. Yazdi , et al. · 2025

Introduction: Psychiatric disorders such as depression and anxiety are prevalent but often unrecognized in orthopedic settings. While psychiatric conditions are known to affect functional outcomes in a variety of orthopedic procedures, lim…

An Ultra-Potent, Ultra-Economical, Antifreeze Polypeptide Open

Thomas McPartlon, Charles Osborne, Ke Wang, Rachel E. Detwiler, Konrad Meister , et al. · 2025

The coarsening of ice crystals during freeze and thaw events is a challenge in diverse settings from transportation and agriculture to foods and biomedicine. Design, synthesis, and evaluation of antifreeze polypeptides that inhibit ice cry…

A Reverse Transcription Nucleic-Acid-Based Barcoding System for In Vivo Measurement of Lipid Nanoparticle mRNA Delivery Open

Ke Wang, Tiana L. Young, Jingan Chen, Shannon J. Tsai, Yue Xu , et al. · 2025

Lipid nanoparticles (LNPs) are the most extensively validated clinical delivery vehicles for mRNA therapeutics, exemplified by their widespread use in the mRNA COVID-19 vaccines. The pace of lipid nanoparticle (LNP) development for mRNA th…

Selection of dysfunctional alleles of bHLH1 and MYB1 has produced white grain in the tribe Triticeae Open

Jiawei Pei, Z. Wang, Yanfang Heng, Zhuo Chen, Ke Wang , et al. · 2025

Canadian Trends in Estimated Drug Purchases and Projections: 2024 and 2025 Open

Mina Tadrous, Ke Wang, Shanzeh Chaudhry, C.Y. Chu, Fiona Clement , et al. · 2024

What Is the issue? Data on trends in the pharmaceutical market remain limited. We offer an annual update on estimated drug purchases in Canada and highlight key factors that could impact future spending. What Did We do? We conducted a retr…

Trim72 is a major host factor protecting against lethal Candida albicans infection Open

Wang Tan, Jiayu Liu, Renlin Yu, Ping Zhao, Yuhan Liu , et al. · 2024

Candida albicans is the most common aetiologic pathogen of fungal infections associated with high mortality in immunocompromised patients. There is an urgent need to develop new antifungal therapies owing to the poor efficacy and resistanc…

TM9SF1 expression correlates with autoimmune disease activity and regulates antibody production through mTOR-dependent autophagy Open

Juan Xiao, Zhen-Wang Zhao, Fengqiao Zhou, Jinsong Xiong, Zean Yang , et al. · 2024

CCL2-mediated endothelial injury drives cardiac dysfunction in long COVID Open

Dilip Thomas, Chikage Noishiki, Sadhana Gaddam, David Wu, Amit Manhas , et al. · 2024

Super-enhancer interactomes from single cells link clustering and transcription Open

Derek J. Le, Antonina Hafner, Sadhana Gaddam, Ke Wang, Alistair N. Boettiger · 2024

Summary Regulation of gene expression hinges on the interplay between enhancers and promoters, traditionally explored through pairwise analyses. Recent advancements in mapping genome folding, like GAM, SPRITE, and multi-contact Hi-C, have …

Probiotic Mixture Ameliorates a Diet-Induced MASLD/MASH Murine Model through the Regulation of Hepatic Lipid Metabolism and the Gut Microbiome Open

Fangfei Zhang, Emily Kwun Kwan Lo, Jiarui Chen, Ke Wang, Felicianna , et al. · 2024

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a prevalent metabolic disease that has no effective treatment. Our proprietary probiotic mixture, Prohep, has been proven in a previous study to be helpful in reducing hep…

Postoperative Pyoderma Gangrenosum in a Patient Presenting with Acute Peripheral Artery Disease Secondary to Antiphospholipid Syndrome: A Case Report Open

Haijun Wei, Ke Wang, Wei Huang, Yang Liu · 2024

Pyoderma gangrenosum (PG) is a rare autoinflammatory neutrophilic dermatosis clinically characterized by painful nodules, red papules or plaques that rapidly erode into ulcers. We report a 53-year-old febrile male patient with acute periph…

NUPR1 contributes to activate TFE3-dependent autophagy leading to cervical cancer proliferation Open

Xiaoguang Wang, Ke Wang, Xiuli Wang · 2024

Identification of constrained sequence elements across 239 primate genomes Open

Lukas F. K. Kuderna, Jacob C. Ulirsch, Sabrina Mohd Rashid, Mohamed Ameen, Laksshman Sundaram , et al. · 2023

Deep learning the cis-regulatory code of chromatin dynamics during cellular reprogramming Open

Surag Nair, Mohamed Ameen, Laksshman Sundaram, Anusri Pampari, Jacob Schreiber , et al. · 2023

The concentration and stoichiometry of transcription factors (TFs) determine cellular identity and can be manipulated to drive cell state transitions. Understanding how changes in TF concentration regulate chromatin state and expression ac…

Mapped data: Transcription factor stoichiometry, motif affinity and syntax regulate single cell chromatin dynamics during fibroblast reprogramming to pluripotency Open