Kevork Hagopian
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View article: A ketogenic diet impacts markers of mitochondrial mass in a tissue specific manner in aged mice
A ketogenic diet impacts markers of mitochondrial mass in a tissue specific manner in aged mice Open
Declines in mitochondrial mass are thought to be a hallmark of mammalian aging, and a ketogenic diet (KD) may prevent the age-related decreases in mitochondrial content. The objective of this study was to investigate the impact of a KD on …
View article: A Ketogenic Diet Extends Longevity and Healthspan in Adult Mice
A Ketogenic Diet Extends Longevity and Healthspan in Adult Mice Open
View article: The influence of Shc proteins and high‐fat diet on energy metabolism of mice
The influence of Shc proteins and high‐fat diet on energy metabolism of mice Open
The purpose of this study was to determine if Shc proteins influence the metabolic response to acute (7 days) feeding of a high‐fat diet (HFD). To this end, whole animal energy expenditure (EE) and substrate oxidation were measured in the …
View article: A Ketogenic Diet Extends Longevity and Healthspan in Adult Mice
A Ketogenic Diet Extends Longevity and Healthspan in Adult Mice Open
View article: Mice with low levels of Shc proteins display reduced glycolytic and increased gluconeogenic activities in liver
Mice with low levels of Shc proteins display reduced glycolytic and increased gluconeogenic activities in liver Open
View article: p46Shc Inhibits Thiolase and Lipid Oxidation in Mitochondria
p46Shc Inhibits Thiolase and Lipid Oxidation in Mitochondria Open
Although the p46Shc isoform has been known to be mitochondrially localized for 11 years, its function in mitochondria has been a mystery. We confirmed p46Shc to be mitochondrially localized and showed that the major mitochondrial partner o…
View article: Key Glycolytic Enzyme Activities of Skeletal Muscle Are Decreased under Fed and Fasted States in Mice with Knocked Down Levels of Shc Proteins
Key Glycolytic Enzyme Activities of Skeletal Muscle Are Decreased under Fed and Fasted States in Mice with Knocked Down Levels of Shc Proteins Open
Shc proteins interact with the insulin receptor, indicating a role in regulating glycolysis. To investigate this idea, the activities of key glycolytic regulatory enzymes and metabolites levels were measured in skeletal muscle from mice wi…