Explanipedia

A gastric retentive robotic capsule enables emergency-prepared and responsive oral drug delivery in canine models Open

Hao Huang, Yunlong Fan, Zhenlin Chen, Huihui Hu, Yidan Lyu , et al. · 2025

Existing oral drug delivery modalities often fall short in medical emergencies due to the absence of readily deployable, internalized drug storage and delivery mechanisms that combine long-term standby with rapid activation. To address thi…

Liquid-based encapsulation for implantable bioelectronics across broad pH environments Open

He Sun, Xiaoting Xue, Gabriella L. Robilotto, Xincheng Zhang, ChangHee Son , et al. · 2025

Stimuli-responsive hydrogel actuators for skin therapeutics and beyond Open

Ningjie Du, Yunlong Fan, Hao Huang, Yi‐Xin Guan, Kewang Nan · 2024

Stimuli-responsive hydrogels are innovative soft materials that have garnered significant attention in recent years. These hydrogels can undergo phase transitions or structural changes in response to external stimuli, offering considerable…

Wireless, Programmable, and Refillable Hydrogel Bioelectronics for Enhanced Diabetic Wound Healing Open

Ningjie Du, Yunlong Fan, Yunting Zhang, Hao Huang, Yidan Lyu , et al. · 2024

Diabetic wounds, characterized by complex pathogenesis and high infection rates, pose significant challenges in treatment due to prolonged recovery times and high recurrence rates, often leading to severe complications such as amputation a…

Wearable bio-adhesive metal detector array (BioMDA) for spinal implants Open

Jian Li, Shengxin Jia, Dengfeng Li, Lung Chow, Qiang Zhang , et al. · 2024

An ingestible, battery-free, tissue-adhering robotic interface for non-invasive and chronic electrostimulation of the gut Open

Kewang Nan, Kiwan Wong, Dengfeng Li, Binbin Ying, James C. McRae , et al. · 2024

An ingestible, battery-free, tissue-adhering robotic interface for non-invasive and chronic electrostimulation of the gut Open

Kewang Nan, Kiwan Wong, Dengfeng Li, Binbin Ying, James C. McRae , et al. · 2024

Ingestible electronics have the capacity to transform our ability to effectively diagnose and potentially treat a broad set of conditions. Current applications could be significantly enhanced by addressing poor electrode-tissue contact, la…

Electroadhesive hydrogel interface for prolonged mucosal theranostics Open

Binbin Ying, Kewang Nan, Qing Zhu, Tom Khuu, Hana Ro , et al. · 2023

Establishing a robust and intimate mucosal interface that allows medical devices to remain within lumen-confined organs for extended periods has valuable applications, particularly for gastrointestinal (GI) theranostics. Here, we report th…

Engineered bacteria for augmented<i>in situ</i>tumor vaccination Open

Xinyuan Shen, Chaojie Zhu, Xutao Liu, Hanqi Zheng, Qing Wu , et al. · 2023

Engineered bacteria can be leveraged for in situ tumor vaccinations with their tumor-targeting ability and adjuvanticity. Engineering strategies like chemical modification, nanotechnology, and genetic engineering improve their safety and e…

Scalable Electrophysiology of Millimeter-Scale Animals with Electrode Devices Open

Kairu Dong, Wen-Che Liu, Yuyan Su, Yidan Lyu, Hao Huang , et al. · 2023

Millimeter-scale animals such as Caenorhabditis elegans , Drosophila larvae, zebrafish, and bees serve as powerful model organisms in the fields of neurobiology and neuroethology. Various methods exist for recording large-scale electrophys…

Actively Triggerable Metals via Liquid Metal Embrittlement for Biomedical Applications Open

Vivian R. Feig, Eva Remlova, Benjamin Muller, Johannes Kuosmanen, Nikhil B. Lal , et al. · 2022

Actively triggerable materials, which break down upon introduction of an exogenous stimulus, enable precise control over the lifetime of biomedical technologies, as well as adaptation to unforeseen circumstances, such as changes to an esta…

Mucosa-interfacing electronics Open

Kewang Nan, Vivian R. Feig, Binbin Ying, Julia G. Howarth, Ziliang Kang , et al. · 2022

Smart Contact Lenses for Biosensing Applications Open

Xin Ma, Samad Ahadian, Song Liu, Jingwen Zhang, Shengnan Liu , et al. · 2021

Smart Contact Lenses Smart contact lenses are highly integrated devices with multifunctional capabilities for the diagnosis of eye diseases and the delivery of drugs. In article number 2000263, Samad Ahadian, Ali Khademhosseini, and co-wor…

Smart Contact Lenses for Biosensing Applications Open

Xin Ma, Samad Ahadian, Song Liu, Jingwen Zhang, Sheng-Nan Liu , et al. · 2021

Smart contact lenses have emerged as novel wearable devices. Due to their multifunctional biosensing capabilities and highly integrated performance, they provide a great platform for the diagnosis of eye diseases and the delivery of drugs.…

Cyborg Organoids: Implantation of Nanoelectronics via Organogenesis for Tissue-Wide Electrophysiology Open

Qiang Li, Kewang Nan, Paul Le Floch, Zuwan Lin, Hao Sheng , et al. · 2019

Tissue-wide electrophysiology with single-cell and millisecond spatiotemporal resolution is critical for heart and brain studies, yet issues arise from invasive, localized implantation of electronics that destructs the well-connected cellu…

A mechanically-guided approach to three-dimensional functional mesostructures towards unconventional applications Open

Kewang Nan · 2018

Controlled formation of three-dimensional functional mesostructures (3DFMs) has broad engineering implications in biomedical devices, microelectromechanical systems (MEMS), optics, and energy storage. Most existing 3D techniques, however, …

Soft Three-Dimensional Microscale Vibratory Platforms for Characterization of Nano-Thin Polymer Films Open

Kewang Nan, Heling Wang, Xin Ning, Kali A. Miller, Chen Wei , et al. · 2018

Vibrational resonances of microelectromechanical systems (MEMS) can serve as means for assessing physical properties of ultrathin coatings in sensors and analytical platforms. Most such technologies exist in largely two-dimensional configu…

Compliant and stretchable thermoelectric coils for energy harvesting in miniature flexible devices Open

Kewang Nan, Stephen Dongmin Kang, Kan Li, Ki Jun Yu, Feng Zhu , et al. · 2018

Thermoelectric coils for energy harvesting are fabricated in miniature flexible devices.

Freestanding 3D Mesostructures, Functional Devices, and Shape‐Programmable Systems Based on Mechanically Induced Assembly with Shape Memory Polymers Open

Xueju Wang, Xiaogang Guo, Jilong Ye, Ning Zheng, Punit Kohli , et al. · 2018

Capabilities for controlled formation of sophisticated 3D micro/nanostructures in advanced materials have foundational implications across a broad range of fields. Recently developed methods use stress release in prestrained elastomeric su…

Two-dimensional materials in functional three-dimensional architectures with applications in photodetection and imaging Open

Wonho Lee, Yuan Liu, Yongjun Lee, Bhupendra K. Sharma, Sachin M. Shinde , et al. · 2018

Morphable 3D mesostructures and microelectronic devices by multistable buckling mechanics Open

Haoran Fu, Kewang Nan, Wubin Bai, Wen Huang, Ke Bai , et al. · 2018

Three-dimensional mesostructures as high-temperature growth templates, electronic cellular scaffolds, and self-propelled microrobots Open

Zheng Yan, Mengdi Han, Yan Shi, Adina Badea, Yiyuan Yang , et al. · 2017

Significance Exploiting advanced 3D designs in micro/nanomanufacturing inspires potential applications in various fields including biomedical engineering, metamaterials, electronics, electromechanical components, and many others. The resul…

3D Scaffolds: Deterministic Integration of Biological and Soft Materials onto 3D Microscale Cellular Frameworks (Adv. Biosys. 9/2017) Open

Joselle M. McCracken, Sheng Xu, Adina Badea, Kyung‐In Jang, Zheng Yan , et al. · 2017

In article number 1700068, John A. Rogers, Ralph G. Nuzzo, and co-workers present direct ink write (DIW)-assisted integration of soft and cellular materials onto compressively buckled microframeworks that are constructed using polymer or h…

Deterministic Integration of Biological and Soft Materials onto 3D Microscale Cellular Frameworks Open

Joselle M. McCracken, Sheng Xu, Adina Badea, Kyung‐In Jang, Zheng Yan , et al. · 2017

Complex 3D organizations of materials represent ubiquitous structural motifs found in the most sophisticated forms of matter, the most notable of which are in life‐sustaining hierarchical structures found in biology, but where simpler exam…

Controlled Mechanical Buckling for Origami‐Inspired Construction of 3D Microstructures in Advanced Materials Open

Zheng Yan, Fan Zhang, Jiechen Wang, Fei Liu, Xuelin Guo , et al. · 2017

Adv. Funct. Mater. 2016, 26, 2629 Guided Formation of 3D Helical Mesostructures by Mechanical Buckling: Analytical Modeling and Experimental Validation Yuan Liu, Zheng Yan, Qing Lin, Xuelin Guo, Mengdi Han, Kewang Nan, Keh-Chih Hwang, Yong…

Mechanically‐Guided Deterministic Assembly of 3D Mesostructures Assisted by Residual Stresses Open

Haoran Fu, Kewang Nan, Paul Froeter, Wen Huang, Yuan Liu , et al. · 2017

Formation of 3D mesostructures in advanced functional materials is of growing interest due to the widespread envisioned applications of devices that exploit 3D architectures. Mechanically guided assembly based on compressive buckling of 2D…

3D Tunable, Multiscale, and Multistable Vibrational Micro‐Platforms Assembled by Compressive Buckling Open

Xin Ning, Heling Wang, Xinge Yu, Julio A. N. T. Soares, Zheng Yan , et al. · 2017

Microelectromechanical systems remain an area of significant interest in fundamental and applied research due to their wide ranging applications. Most device designs, however, are largely 2D and constrained to only a few simple geometries.…

Engineered Elastomer Substrates for Guided Assembly of Complex 3D Mesostructures by Spatially Nonuniform Compressive Buckling Open

Kewang Nan, Haiwen Luan, Zheng Yan, Xin Ning, Yiqi Wang , et al. · 2016

Approaches capable of creating 3D mesostructures in advanced materials (device‐grade semiconductors, electroactive polymers, etc.) are of increasing interest in modern materials research. A versatile set of approaches exploits transformati…

Mechanical assembly of complex, 3D mesostructures from releasable multilayers of advanced materials Open

Zheng Yan, Fan Zhang, Fei Liu, Mengdi Han, Dapeng Ou , et al. · 2016

Buckling-driven assembly of 3D mesostructures from releasable multilayers offers versatile design options for unique applications.

3D Assembly: Controlled Mechanical Buckling for Origami‐Inspired Construction of 3D Microstructures in Advanced Materials (Adv. Funct. Mater. 16/2016) Open

Zheng Yan, Fan Zhang, Jiechen Wang, Fei Liu, Xuelin Guo , et al. · 2016

On page 2629, Y. Zhang, J. A. Rogers, and co-workers introduce an approach that exploits controlled mechanical buckling for reversible, autonomic origami assembly of 3D structures across material classes from soft polymers to brittle inorg…

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