Kewei Ren
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View article: Protonation of Covalent Organic Framework with Robust Built‐In Electric Field for Dual Electrochemiluminescence Enhancement
Protonation of Covalent Organic Framework with Robust Built‐In Electric Field for Dual Electrochemiluminescence Enhancement Open
Covalent organic frameworks (COFs) have emerged as promising electrochemiluminescence (ECL) emitters. To achieve the application, herein a dual ECL enhancement strategy is proposed for imine‐linked COF by incorporating bipyridine units and…
View article: Dual-key cooperatively activated DNA regulator for controlling mitochondria-lysosome interactions
Dual-key cooperatively activated DNA regulator for controlling mitochondria-lysosome interactions Open
Mitochondria-lysosome interactions are critical for maintaining cellular homeostasis. Although genetically encoded protein based optogenetic technique is developed to regulate such interactions, it still suffers from shortcomings including…
View article: Programmable RNA multiphasic condensates and act as micromotor for biomoleculeas delivery
Programmable RNA multiphasic condensates and act as micromotor for biomoleculeas delivery Open
Multiphasic condensates are important to biochemical processes and cellular functions. The controllable assembly and mechanism deciphering of multiphase condensates contribute to understand the molecular mechanism of biological structures,…
View article: Ultrasensitive RNase H activity detection using the transcription-based hybrid probe and CRISPR/cas12a signal amplifier
Ultrasensitive RNase H activity detection using the transcription-based hybrid probe and CRISPR/cas12a signal amplifier Open
Ribonuclease H (RNase H), a critical functional protein in replication and genome stability, is emerging as a crucial therapeutic target for various diseases, including immune disorders. We present a transcription-based hybrid probe, refer…
View article: Dual-key cooperatively activated DNA regulator for controlling mitochondria-lysosome interactions
Dual-key cooperatively activated DNA regulator for controlling mitochondria-lysosome interactions Open
Mitochondria-lysosome interactions are critical for maintaining cellular homeostasis. Although genetically encoded protein based optogenetic technique has been developed to regulate such interactions, it still suffers from shortcomings inc…
View article: Implantable Multifunctional Micro‐Oxygen Reservoir System for Promoting Vascular‐Osteogenesis via Remodeling Regenerative Microenvironment
Implantable Multifunctional Micro‐Oxygen Reservoir System for Promoting Vascular‐Osteogenesis via Remodeling Regenerative Microenvironment Open
Hypoxia and reactive oxygen species (ROS) overaccumulation cause persistent oxidative stress and impair intrinsic regenerative potential upon tissue injury. For local tissue injury with hypoxia, such as bone fracture and defects, a localiz…
View article: Genome-Wide Association Studies for Wheat Height Under Different Nitrogen Conditions
Genome-Wide Association Studies for Wheat Height Under Different Nitrogen Conditions Open
Lodging causes a reduction in wheat (Triticum aestivum L.) yield and quality. A shorter plant height (PH) can reduce the incidence of lodging. The overuse of nitrogen promotes excessive vegetative growth, leads to taller plants, and increa…
View article: Genome-Wide Identification, Characterization and Expression Patterns of the DBB Transcription Factor Family Genes in Wheat
Genome-Wide Identification, Characterization and Expression Patterns of the DBB Transcription Factor Family Genes in Wheat Open
Double B-box (DBB) proteins are plant-specific transcription factors (TFs) that play crucial roles in plant growth and stress responses. This study investigated the classification, structure, conserved motifs, chromosomal locations, cis-el…
View article: Multiplexed sequential imaging in living cells with orthogonal fluorogenic RNA aptamer/dye pairs
Multiplexed sequential imaging in living cells with orthogonal fluorogenic RNA aptamer/dye pairs Open
Detecting multiple targets in living cells is important in cell biology. However, multiplexed fluorescence imaging beyond two-to-three targets remains a technical challenge. Herein, we introduce a multiplexed imaging strategy, ‘sequential …
View article: A Generic Deep Learning–Based Computing Algorithm in Support of the Development of Instrumented Bikes
A Generic Deep Learning–Based Computing Algorithm in Support of the Development of Instrumented Bikes Open
The paper introduces a generic deep learning–based method using a sliding window computing algorithm based on long short-term memory (LSTM) networks for the classification of potential anomalies (e.g., cracks, potholes, bumps, and uneven s…
View article: Fluorogenic Rna Aptamer Based Artificial Membraneless Organelles for Small Molecule and Cell Sensing
Fluorogenic Rna Aptamer Based Artificial Membraneless Organelles for Small Molecule and Cell Sensing Open
View article: XJB-5-131 protects chondrocytes from ferroptosis to alleviate osteoarthritis progression via restoring Pebp1 expression
XJB-5-131 protects chondrocytes from ferroptosis to alleviate osteoarthritis progression via restoring Pebp1 expression Open
View article: Message in a bubble: the translational potential of extracellular vesicles
Message in a bubble: the translational potential of extracellular vesicles Open
Extracellular vesicles (EVs) are small, membrane‐enclosed vesicles released by cells into the extracellular milieu. They are found in all body fluids and contain a variety of functional cargo including DNA, RNA, proteins, glycoproteins and…
View article: Logic Gate Activated Lysosome Targeting DNA Nanodevice for Controlled Proteins Degradation
Logic Gate Activated Lysosome Targeting DNA Nanodevice for Controlled Proteins Degradation Open
Targeted protein degradation (TPD) is a powerful technique for regulation of protein homeostasis. Current TPD mainly focuses on the therapeutical consequences rather than the operation processes of the molecular tools. Herein, we construct…
View article: Targeted RNA condensation in living cells via genetically encodable triplet repeat tags
Targeted RNA condensation in living cells via genetically encodable triplet repeat tags Open
Living systems contain various membraneless organelles that segregate proteins and RNAs via liquid–liquid phase separation. Inspired by nature, many protein-based synthetic compartments have been engineered in vitro and in living cells. He…
View article: Multiplexed Sequential Imaging in Living Cells with Orthogonal Fluorogenic RNA Aptamer/Dye Pairs
Multiplexed Sequential Imaging in Living Cells with Orthogonal Fluorogenic RNA Aptamer/Dye Pairs Open
Single-cell detection of multiple target analytes is an important goal in cell biology. However, due to the spectral overlap of common fluorophores, multiplexed fluorescence imaging beyond two-to-three targets inside living cells remains a…
View article: Targeted RNA Condensation in Living Cells via Genetically Encodable Triplet Repeat Tags
Targeted RNA Condensation in Living Cells via Genetically Encodable Triplet Repeat Tags Open
Living systems contain various functional membraneless organelles that can segregate selective proteins and RNAs via liquid–liquid phase separation. Inspired by nature, many synthetic compartments have been engineered in vitro and in livin…
View article: Genetically Encoded RNA-Based Bioluminescence Resonance Energy Transfer (BRET) Sensors
Genetically Encoded RNA-Based Bioluminescence Resonance Energy Transfer (BRET) Sensors Open
RNA-based nanostructures and molecular devices have become popular for developing biosensors and genetic regulators. These programmable RNA nanodevices can be genetically encoded and modularly engineered to detect various cellular targets …
View article: Controllable mitochondrial aggregation and fusion by a programmable DNA binder
Controllable mitochondrial aggregation and fusion by a programmable DNA binder Open
DNA nano-binder has been designed as the artificial controller for the aggregation and fusion of mitochondria in living cells.
View article: Controllable mitochondrial aggregation and fusion by a programmable DNA binder
Controllable mitochondrial aggregation and fusion by a programmable DNA binder Open
DNA nanodevices have been feasibly applied for various chemo-biological applications, but their functions as precise regulators of intracellular organelles are still limited. Here, we report a synthetic DNA binder that can artificially ind…
View article: Genetically Encoded RNA-based Bioluminescence Resonance Energy Transfer (BRET) Sensors
Genetically Encoded RNA-based Bioluminescence Resonance Energy Transfer (BRET) Sensors Open
RNA-based nanostructures and molecular devices have become popular for developing biosensors and genetic regulators. These programmable RNA nanodevices can be genetically encoded and modularly engineered to detect various cellular targets …
View article: Loss to follow-up after surgery in patients with hip fractures
Loss to follow-up after surgery in patients with hip fractures Open
Background: Non-attendance with scheduled postoperative follow-up visits remains a common problem in orthopaedic clinical researches. The goal of this study was to determine the risk factors for loss to follow-up of hip-fracture patients p…
View article: Thermal Hazard Characteristics of Unsaturated Polyester Resin Mixed with Hardeners
Thermal Hazard Characteristics of Unsaturated Polyester Resin Mixed with Hardeners Open
Unsaturated polyester resin (UP) is a critical polymer material in applications of many fields, such as the chemical industry, military, and architecture. For improving the mechanical properties, some hardeners, such as methyl ethyl ketone…
View article: Genetically encoded RNA nanodevices for cellular imaging and regulation
Genetically encoded RNA nanodevices for cellular imaging and regulation Open
Recent design and applications of emerging genetically encoded RNA nanodevices in regulating cellular gene expression, imaging, logic operation, structural biology, and optogenetics.
View article: Efficient and selective DNA modification on bacterial membranes
Efficient and selective DNA modification on bacterial membranes Open
A lipid-based approach to effectively modify DNA molecules onto various types of bacterial membranes after simple incubation.
View article: A Genetically Encoded RNA Photosensitizer for Targeted Cell Regulation
A Genetically Encoded RNA Photosensitizer for Targeted Cell Regulation Open
Genetically encoded RNA devices have emerged for various cellular applications in imaging and biosensing, but their functions as precise regulators in living systems are still limited. Inspired by protein photosensitizers, we propose here …
View article: <i>In Situ</i> Genetically Cascaded Amplification for Imaging RNA Subcellular Locations
<i>In Situ</i> Genetically Cascaded Amplification for Imaging RNA Subcellular Locations Open
In situ amplification methods, such as hybridization chain reaction, are valuable tools for mapping the spatial distribution and subcellular location of target analytes. However, the live-cell applications of these methods are still…
View article: Loss of Klotho contributes to cartilage damage by derepression of canonical Wnt/β-catenin signaling in osteoarthritis mice
Loss of Klotho contributes to cartilage damage by derepression of canonical Wnt/β-catenin signaling in osteoarthritis mice Open
Caducity is known to be an independent risk factor in osteoarthritis (OA), yet the molecular basis behind caducity and OA remains unclear. Klotho, an anti-caducity protein, is an endogenous antagonist of the transduction of Wnt/β-catenin s…
View article: Genetically Encoded Ratiometric RNA‐Based Sensors for Quantitative Imaging of Small Molecules in Living Cells
Genetically Encoded Ratiometric RNA‐Based Sensors for Quantitative Imaging of Small Molecules in Living Cells Open
Precisely determining the intracellular concentrations of metabolites and signaling molecules is critical in studying cell biology. Fluorogenic RNA‐based sensors have emerged to detect various targets in living cells. However, it is still …
View article: “Second-generation” fluorogenic RNA-based sensors
“Second-generation” fluorogenic RNA-based sensors Open