Explanipedia

Artificial Intelligence Revolutionizes Anti‐Infective Drug Discovery: From Target Identification to Lead Optimization Open

Kexin Li, Quan Yuan, Chang Qi, Ying Shi, Hong Yang , et al. · 2025

The Role of Protein Arginine Methylation as a Post-Translational Modification in Cellular Homeostasis and Disease Open

Ke Li, Qing Xia, Kexin Li, Wenxin Yan, Changshan Wang · 2025

Post-translational modifications (PTMs) of proteins in eukaryotic cells are essential for regulating proteome function and maintaining cellular homeostasis. Among these, the methylation modification of arginine has received much attention …

Tranilast ameliorates experimental abdominal aortic aneurysm by inhibiting the NLRP3 inflammasome pathway Open

Haole Liu, Kangli Tian, Weilai Fu, Le Qin, Runyu Tian , et al. · 2025

Sequential Extraction of Naringin and Low-Ester Pectin from Naturally Dropped Fruit of Pomelo Open

Bo Yu, Liwen Huang, Yuhan Ding, Ning Zhang, Kexin Li , et al. · 2025

Naringin and pectin were innovatively and sequentially extracted from naturally dropped fruit of pomelo (NDFP), optimizing yields via response surface methodology (RSM). Under optimized conditions, naringin was extracted first with 70% eth…

SMCseeker: An attentive virtual screening model for antiviral discovery Open

Jing Li, Haoran Sun, Xiao‐Ou Shu, Min Guo, Yubin Xie , et al. · 2025

Analysis of reasons and risk factors for non-completion of radiotherapy courses in patients with tumors Open

M Chen, Kexin Li, Xuan Gao, Xia Ye, Yongjian Ju · 2025

Purpose Non-completion of radiotherapy courses (NCRC) may happen in patients undergoing intensity-modulated radiotherapy (IMRT). Analyzing the reasons and risk factors for NCRC can lead to possible targeted measures to reduce the incidence…

Oxidative–Inflammatory Crosstalk and Multi-Target Natural Agents: Decoding Diabetic Vascular Complications Open

Jingwen Liu, Kexin Li, Zhengping Yi, Saqirile, Changshan Wang , et al. · 2025

Diabetes mellitus (DM) is one of the leading causes of death and disability worldwide and its prevalence continues to rise. Chronic hyperglycemia exposes patients to severe complications. Among these, diabetic vascular lesions are the most…

Quantifying the influencing factors and predictive analysis of cotton defoliation and maturation based on machine learning Open

Yukun Wang, Chenyu Xiao, Kexin Li, Meng Lu, Xinghu Song , et al. · 2025

Intra-aortic infusion of nicotine can induce a novel mouse model of abdominal aortic aneurysm Open

Haole Liu, Le Qin, Jiawei Zou, Kangli Tian, Kexin Li , et al. · 2025

In this study, we established a novel and highly efficient experimental AAA model via direct intraluminal nicotine infusion. We also demonstrated that nicotine-induced AAA formation is partially dependent on the activation of its receptors…

Distribution characteristics and influencing factors of overweight and obesity among urban and rural primary and secondary school students in Hunan Province. Open

Liyuan Qin, Miyang Luo, Kexin Li, Yang Zhou, Yanhua Chen , et al. · 2025

The situation of overweight and obesity among primary and secondary school students in Hunan Province remains concerning. Greater attention should be paid to regions with high-value clusters of overweight/obesity, and targeted intervention…

Structural and functional analysis of a homotrimeric collagen peptide Open

Xinling Zhang, Kexin Li, Nan Lu, Takafumi Takebayashi, Boyu Zhou , et al. · 2025

Objective This study aimed to chemically synthesize a homotrimeric collagen peptide, evaluate its safety, and assess its effectiveness in promoting collagen synthesis. Methods A homotrimeric collagen peptide was synthesized and structurall…

Ultra-high pressure treatment improves the gel properties of Lentinan edodes polysaccharides-chicken myofibrillar protein composite Open

Jiahui Li, Liang Li, Kexin Li, Dajun Ren, Hongjian Wan , et al. · 2025

Integration of machine learning and experimental validation reveals new lipid-lowering drug candidates Open

Jinghong Chen, Kexin Li, Huihui Fan, Hong Yang, Zhi-Rou Zhang , et al. · 2025

The Role of N6-Methyladenosine in Mitochondrial Dysfunction and Pathology Open

Wenxin Yan, Saqirile, Ke Li, Kexin Li, Changshan Wang · 2025

Mitochondria are indispensable in cells and play crucial roles in maintaining cellular homeostasis, energy production, and regulating cell death. Mitochondrial dysfunction has various manifestations, causing different diseases by affecting…

BRD1 deficiency affects SREBF1-related lipid metabolism through regulating H3K9ac/H3K9me3 transition to inhibit HCC progression Open

Mingyang Zhang, Jing Bai, Hailong Yuan, Xiaojun Duan, Lei Yu , et al. · 2025

HDGF Knockout Suppresses Colorectal Cancer Progression and Drug Resistance by Modulating the DNA Damage Response Open

Riya Su, Qin Wang, Qun Hu, Wendurige, Kexin Li , et al. · 2025

Colorectal cancer (CRC) is a highly heterogeneous gastrointestinal malignancy. Despite significant advances in molecular targeted therapies for CRC in recent years, the increase in the overall survival rates for CRC patients remains limite…

Author Correction: The heterogeneity of NOTCH1 to tumor immune infiltration in pan-cancer Open

Xiaojun Duan, Rihan Wu, Mingyang Zhang, Kexin Li, Lei Yu , et al. · 2025

Kuiyangling Enema Alleviates Ulcerative Colitis Mice by Reducing Levels of Intestinal NETs and Promoting HuR/VDR Signaling Open

Dong Zhang, Zeming Zhu, Zhangyou He, Siwei Duan, Qincheng Yi , et al. · 2025

Kuiyangling enema in treating ulcerative colitis in mice, associated with a reduction in intestinal NETs and enhancement of HuR-mediated intestinal barrier signaling pathways.

Tranilast Ameliorates Experimental Abdominal Aortic Aneurysm by Inhibiting the NLRP3 Inflammasome Pathway Open

Haole Liu, Kangli Tian, Weilai Fu, Le Qin, Runyu Tian , et al. · 2025

Investigating the Role of Food-Derived Peptides in Hyperuricemia: From Mechanisms of Action to Structural Effects Open

Yu Han, Wanlu Liu, Kexin Li, M. Zhang, Xinqi Liu , et al. · 2024

Hyperuricemia, a disorder of purine metabolism associated with cardiovascular disease, gout, and kidney disease, can be alleviated by food-derived peptides. However, the precise mechanisms remain unclear, hindering their development. This …

Polyvinylidene Fluoride Nanofiber Murray Membrane for Quick Oil Absorption Open

Kexin Li, Gang Feng, Guangming Li, Z. Zhang, Jia Xiang , et al. · 2024

With the rapid advancement of global industrialization, there is an increasing year-on-year demand for oil in society. The occurrence of oil spills during the processes of development, refining, and transportation has become an urgent issu…

Construction of a neutrophil extracellular trap formation-related gene model for predicting the survival of lung adenocarcinoma patients and their response to immunotherapy Open

Y. Wang, Shuang Liang, Hong Qian, Juwei Mu, Yuxin Wu , et al. · 2024

We developed a novel prognostic signature for LUAD patients based on NFRGs and emphasized the critical role of this signature in predicting LUAD patient survival and immunotherapy response.

Correction for: DNA N6-methyladenine modification in hypertension Open

Ye Guo, Yuqing Pei, Kexin Li, Wei Cui, Donghong Zhang · 2024

The heterogeneity of NOTCH1 to tumor immune infiltration in pan-cancer Open

Xiaojun Duan, Rihan Wu, Mingyang Zhang, Kexin Li, Lei Yu , et al. · 2024

NOTCH1 signaling, a vital regulator of cell proliferation and differentiation, is widely involved in the occurrence and development of malignant tumors. Pharmacological regulation of NOTCH1 is promising in tumor immunotherapy, whereas the …

Mechanical control of germ cell specification in Arabidopsis anthers Open

Chan Liu, Hui Shi, Yuting Han, Pan Wang, Kexin Li , et al. · 2024

A central question in developmental biology is how the germline is established. We have studied the specification of the male germ cells (GCs) within the anther 1–3 . Hereby, we have focused on the potential role of mechanics, an aspect of…

Climate gradient‐driven intraspecific aggregation propensity linked to interpatch modulation in grassland communities Open

Huaiqiang Liu, Xinyu Wang, Zhiying Liu, Saihanna Jaesong, Jiayue Liu , et al. · 2024

The response of vegetation to climate change on a large scale should be studied at the community level rather than the species level. This necessitates a focused exploration of emerging spatial patterns. Here, we surveyed 264 sites in the …

The C57BL/6N mouse substrain is a viable model of elastase-induced abdominal aortic aneurysm Open

Panpan Wei, Kexin Li, Meng Li, Haole Liu, Congcong Xia , et al. · 2024

Aim Compared with the C57BL/6N substrain, the C57BL/6J substrain is more susceptible to the angiotensin II (Ang II)-induced development of dissected abdominal aortic aneurysms (AAAs). The aim of this study was to elucidate whether the wide…

Gene Expression Regulation and the Signal Transduction of Programmed Cell Death Open

Saqirile, Yuxin Deng, Kexin Li, Wenxin Yan, Ke Li , et al. · 2024

Cell death is of great significance in maintaining tissue homeostasis and bodily functions. With considerable research coming to the fore, it has been found that programmed cell death presents in multiple modalities in the body, which is n…

Alterations in the diversity and composition of the fecal microbiota of domestic yaks (Bos grunniens) with pasture alteration-induced diarrhea Open

Runbo Luo, DanWu, Zhengzhong Luo, Yupeng Li, Yanan Zhong , et al. · 2024

NOTCH1 collaborated with innate immune to regulate genomic instability caused by epigenetic enzyme deletion in cold tumor Open

Xiaojun Duan, Mingyang Zhang, Kexin Li, Rihan Wu, Lei Yu , et al. · 2024

NOTCH1 was unfavorable to tumor immunoinfiltration in cold tumors. Targeting NOTCH1 for effective immunotherapy has been a challenge. Single cell data analysis found NOTCH1 signaling was gradually activated as lung inflammatory disease pro…

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