Explanipedia

A new clustering: Angiogenesis‐associated molecular classification of lung adenocarcinoma Open

Lin Zhu, Li Zhu, Kai Nie, Yuxuan Zhang, Qunhui Chen , et al. · 2025

Lung adenocarcinoma (LUAD) is a heterogeneous disease with diverse molecular characteristics. In this study, we performed a comprehensive computer analysis of genomic data to identify angiogenesis‐associated molecular subtypes of LUAD. Usi…

Neonatal mouse model reveals pathogenesis of Shanxi Tick Virus 2 isolated from Haemaphysalis longicornis Open

Fan Li, R L Wang, B. Zhang, Guangjun Jin, Jingdong Song , et al. · 2025

Shanxi Tick Virus 2(SXTV2), a Tamdy group member of Orthonairovirus genus, Nairoviridae family, was initially identified through Next Generation Sequencing, with its pathogenicity and risk profile remaining unclear. This study reports the …

Spatiotemporal Distribution and Host–Vector Dynamics of Japanese Encephalitis Virus Open

Qikai Yin, Bin Li, Ruichen Wang, Kai Nie, Shihong Fu , et al. · 2025

Japanese encephalitis (JE), a mosquito-borne viral disease caused by the Japanese encephalitis virus (JEV), remains a significant public health threat in Asia. Although vaccination programs have successfully reduced the incidence of JE, ch…

Facilitating Cross-border Viral Sequencing Through Nucleic Acid Sample Transport Using Dry Cards Open

Lili Wang, Qikai Yin, Alie Brima Tia, Fengyu Tian, Liping Gao , et al. · 2025

(1) Background: A safe and effective nucleic acid sample transportation method was developed that is suitable for underdeveloped areas which lack advanced sequencing capabilities, specifically for virus genomic sequencing and infectious di…

Isolation and characterization of a novel coltivirus from Haemaphysalis concinna ticks in Northeastern China Open

Yuhong Yang, Ji-Xu Li, Ruichen Wang, Qikai Yin, Shihong Fu , et al. · 2025

Exploration of the Pathogenicity and Inflammatory Mechanism of Wuxiang Virus: A Newly Identified Phlebovirus Open

Xiaohui Yao, Qikai Yin, Yuke Zheng, Anqi Gu, Ruichen Wang , et al. · 2025

WUXV is phlebovirus transmitted by sandflies, which can cause death in suckling mice and infect humans and chickens. However, little is known about the pathogenicity and pathogenic mechanisms of animals. Therefore, BALB/c WT mice and BALB/…

Breaking the News: Taking the Roles of Influencer vs. Journalist in a LLM-Based Game for Raising Misinformation Awareness Open

Huiyun Tang, Shuai Sun, Kai Nie, Ang Li, Anastasia Sergeeva , et al. · 2025

Effectively mitigating online misinformation requires understanding of their mechanisms and learning of practical skills for identification and counteraction. Serious games may serve as tools for combating misinformation, teaching players …

Evolutionary Patterns and Genotype-Specific Amino Acid Mutations of Tick-Borne Encephalitis Virus Open

Ruichen Wang, Anqi Gu, Fan Li, Qian Ma, Qikai Yin , et al. · 2025

Tick-borne encephalitis virus (TBEV) is a significant tick-borne flavivirus responsible for severe human diseases. Here, we analyzed the genetic diversity and evolutionary dynamics of TBEV using 263 genome sequences from the NCBI database …

Is the pathogen spectrum of encephalitis/meningitis changing in China? Open

Ruichen Wang, Qikai Yin, Kai Nie, Li Fan, Shihong Fu , et al. · 2025

Exploring Device-Oriented Video Encryption for Hierarchical Privacy Protection in AR Content Sharing Open

Yongquan Hu, Dongsheng Zheng, Kai Nie, Junyan Zhang, Wen Hu , et al. · 2024

Content sharing across multiple Augmented Reality (AR) displays is becoming commonplace, enhancing team communication and collaboration through devices like smartphones and AR glasses. However, this practice raises significant privacy conc…

Research on uncovering parallelism in perfect loop nests for GCC compiler Open

Haoran Li, Pengyan Yan, Haohao Liu, Lin Han, Kai Nie , et al. · 2024

To improve the ability to uncover parallelism in perfect loop nests for the GCC compiler, a method that utilizes the lambda transformation technique to uncover potential parallelism is proposed. Based on data references, dependence distanc…

621 Interim analysis of a phase II study of talimogene laherparepvec (T-VEC) followed by combination T-VEC + nivolumab in non-melanoma skin cancers and refractory cutaneous lymphoma (NCI#10057) Open

Ann W. Silk, Gino K. In, Nicole R. LeBoeuf, Diwakar Davar, Sunandana Chandra , et al. · 2024

Truncated VZV gE Induces High-Titer Neutralizing Antibodies in Mice Open

Jiehui Wu, Li Hai, Yanping Yuan, Ruichen Wang, Tongshuai Shi , et al. · 2024

Backgrounds: A contemporary public health challenge is the increase in the prevalence rates of herpes zoster (HZ) worldwide. Methods: In this work, the gE gene structure was analyzed using bioinformatics techniques, and three plasmids of v…

Separation Process of Plant Fibers for Textile and Composite Application: A Review of Recent Advances Open

Yan Song, Kai Nie, Huan Liu, Wei Jiang, Yuanming Zhang , et al. · 2024

Plant fiber resources have gained significant attention for value-added utilization due to their renewability, sustainability, abundance, and widely acknowledged physical properties. The efficient and pragmatic separation of plant fibers i…

Immunological correlates of suicidality among adolescents with internalizing symptoms Open

Chloe Roske, Tram Nguyen, Joshua Schwartz, Ava Erulker, Kai Nie , et al. · 2024

HLA-E and NKG2A Mediate Resistance to BCG Immunotherapy in Non-Muscle-Invasive Bladder Cancer Open

Daniel Ranti, Haocheng Yu, Alex Wang, C P Bieber, Trine Strandgaard , et al. · 2024

SUMMARY Bacillus Calmette-Guérin (BCG) is the first-line therapy for high-grade non-muscle-invasive bladder cancer (NMIBC), yet many patients experience recurrence due to immune evasion. We identify HLA-E and NKG2A as mediators of adaptive…

Implementation of JPEG XS entropy encoding and decoding on FPGA Open

Shuang Tian, Qinghua Song, Jialin He, Yihan Wang, Kai Nie , et al. · 2024

JPEG XS is the latest international standard for shallow compression fields launched by the International Organization for Standardization (ISO). The coding standard was officially released in 2019. The JPEG XS standard can be encoded and …

Genetic Characteristics of Wuxiang Virus in Shanxi Province, China Open

Yuke Zheng, Xiaodong Tian, Ruichen Wang, Xiaohui Yao, Weijia Zhang , et al. · 2024

Wuxiang virus (WUXV) is the first sandfly-borne Phlebovirus isolated from Phlebotomus chinensis collected in China and has been established as a consistent viral presence in the local sandfly populations of both Wuxiang County and Yangquan…

Human and animal exposure to newly discovered sand fly viruses, China Open

Xiaohui Yao, Qikai Yin, Xiaodong Tian, Yuke Zheng, Hongyan Li , et al. · 2024

Introduction The Hedi virus (HEDV) and Wuxiang virus (WUXV) are newly discovered Bunyaviruses transmitted by sandflies. The geographical distribution of isolation of these two viruses continues to expand and it has been reported that WUXV …

How Does the Remanufacturing Strategy Impact Supplier Counterfeiting? Open

Peilin Wang, Wei Li, Kai Nie · 2024

Detection and Genetic Analysis of Songling Virus in Haemaphysalis concinna near the China-North Korea Border Open

De Li, Jixu Li, Ruichen Wang, Weijia Zhang, Kai Nie , et al. · 2024

Background: Songling virus (SGLV) is a spherical, enveloped, fragmented, negative-stranded RNA virus belonging to the genus Orthonairovirus in the Nairoviridae family. SGLV is transmitted by ticks and can cause disease in humans. This stud…

Metatranscriptomics Reveals the RNA Virome of Ixodes Persulcatus in the China–North Korea Border, 2017 Open

Ruichen Wang, Shenghui Liu, Hongliang Sun, Chongxiao Xu, Yanhan Wen , et al. · 2023

In recent years, numerous viruses have been identified from ticks, and some have been linked to clinical cases of emerging tick-borne diseases. Chinese northeast frontier is tick infested. However, there is a notable lack of systematic mon…

Immunological correlates of suicidality among adolescents with internalizing symptoms Open

Chloe Roske, Joshua Schwartz, Tram Nguyen, Ava Erulker, Kai Nie , et al. · 2023

Background: Suicide is the second leading cause of death in adolescents and young adults in the United States. Well-established risk factors for suicide are depression and past suicide attempts. People experiencing suicidality may represen…

Seroepidemiologocal investigation on the infected genotype in Japanese encephalitis patients in coastal areas of China Open

Weijia Zhang, Jierong Zhao, Qikai Yin, Shenghui Liu, Ruichen Wang , et al. · 2023

Background Japanese encephalitis (JE) is a vaccine-preventable mosquito-borne disease caused by infection with the Japanese encephalitis virus (JEV). G1, G3 and G5 JEV have been isolated in China, but the dominant genotype circulating in C…

A novel cascade organosolv degumming method for preparation of hemp fibers using glycolic acid and ethanolamine Open

Tao Zhao, Wenying Xia, Boya Li, Kai Nie, Yuanming Zhang , et al. · 2023

In an attempt to implement eco-friendly degumming for preparation of hemp fibers. This study developed a cascade organosolv degumming method employing the advantages of both organic acids and organic bases without using any inorganic alkal…

A new clustering: Angiogenesis-Associated Molecular Classification of Lung adenocarcinoma Open

Lin Zhu, Jing Liu, Kai Nie, Yuxuan Zhang, Qunhui Chen , et al. · 2023

Lung adenocarcinoma (LUAD) is a complex disease with unclear molecular characteristics. In this study, a comprehensive computer analysis of genomic data was used to investigate the molecular characteristics of LUAD subtypes based on angiog…

Proteomic characterization of acute kidney injury in patients hospitalized with SARS-CoV2 infection Open

Ishan Paranjpe, Pushkala Jayaraman, Chen‐Yang Su, Sirui Zhou, Steven Chen , et al. · 2023

Novel Orthonairovirus Isolated from Ticks near China–North Korea Border Open

Fan Li, Jixu Li, Jingdong Song, Qikai Yin, Kai Nie , et al. · 2023

We isolated a new orthonairovirus from Dermacentor silvarum ticks near the China-North Korea border. Phylogenetic analysis showed 71.9%-73.0% nucleic acid identity to the recently discovered Songling orthonairovirus, which causes febrile i…

Circulating proteins to predict COVID-19 severity Open

Chen‐Yang Su, Sirui Zhou, Edgar Gonzalez‐Kozlova, Guillaume Butler‐Laporte, Elsa Brunet‐Ratnasingham , et al. · 2023

Tracing the spatiotemporal phylodynamics of Japanese encephalitis virus genotype I throughout Asia and the western Pacific Open

Fan Li, Yun Feng, Guowei Wang, Weijia Zhang, Shihong Fu , et al. · 2023

Background Japanese encephalitis virus (JEV; Flaviridae : Flavivirus ) causes Japanese encephalitis (JE), which is the most important arboviral disease in Asia and the western Pacific. Among the five JEV genotypes (GI–V), GI has dominated …

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