Keyu Li
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View article: Efficacy and Safety of Antifungal Medicines in the Treatment of Invasive Aspergillosis: A Network Meta-Analysis
Efficacy and Safety of Antifungal Medicines in the Treatment of Invasive Aspergillosis: A Network Meta-Analysis Open
A frequentist network meta-analysis (NMA) was conducted to assess the efficacy and safety of voriconazole, posaconazole, isavuconazole, amphotericin B deoxycholate (AmB-D), and liposomal AmB (L-AmB) in the treatment of invasive aspergillos…
View article: Ceramides play a significant role in the response of Pogostemon cablin to bacterial wilt by regulating the ABA pathway
Ceramides play a significant role in the response of Pogostemon cablin to bacterial wilt by regulating the ABA pathway Open
As a strategic resource for both medicine and essential oil, the healthy development of the Pogostemon cablin industry is crucial for the traditional medicine and fragrance sectors. Bacterial wilt represents one of the most significant thr…
View article: Exploration of PDHA1-related prognostic genes in liver fibrosis
Exploration of PDHA1-related prognostic genes in liver fibrosis Open
Liver fibrosis is characterized by an abnormal accumulation of extracellular matrix proteins, leading to impaired liver function. The pyruvate dehydrogenase alpha 1 (PDHA1) gene, encoding the E1 alpha subunit of the pyruvate dehydrogenase …
View article: Development and application of an intelligent platform for automated recognition of surgical instruments in laparoscopic procedures: a multicenter retrospective study (experimental studies)
Development and application of an intelligent platform for automated recognition of surgical instruments in laparoscopic procedures: a multicenter retrospective study (experimental studies) Open
Background: Surgical videos offer rich intraoperative data critical for surgical education, quality control, and skill assessment. However, their increasing volume and complexity render manual review impractical. To address this challenge,…
View article: Imaging observation of allogeneic bone and bone-induced calcium phosphate biomaterials as supplements in the treatment of infectious bone defects
Imaging observation of allogeneic bone and bone-induced calcium phosphate biomaterials as supplements in the treatment of infectious bone defects Open
Objective To compare osseous regeneration efficacy of allogeneic bone versus bone-induced calcium phosphate biomaterial (biological artificial material induced artificial bone, BAM-induced artificial bone) in treating tibial infected bone …
View article: Efficacy and Safety of Biologics and Immunosuppressants in Maintenance Therapy for Antineutrophil Cytoplasmic Antibody-Associated Vasculitis: A Network Meta-Analysis
Efficacy and Safety of Biologics and Immunosuppressants in Maintenance Therapy for Antineutrophil Cytoplasmic Antibody-Associated Vasculitis: A Network Meta-Analysis Open
Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a potentially life-threatening systemic autoimmune disease. This study aims to compare the effectiveness and safety of biologics and immunosuppressive agents in the …
View article: Comparative effect of different corticosteroids in severe community-acquired pneumonia: a network meta-analysis
Comparative effect of different corticosteroids in severe community-acquired pneumonia: a network meta-analysis Open
The present study is a meta-analysis and literature review, therefore clinical trial number is not applicable.
View article: WITHDRAWN: Insights into microbial contamination in paddy field ecology: matagenomic analysis of the abundances, diversity, and distribution of antibiotic resistance genes, virulence factors, and their potential bacterial hosts
WITHDRAWN: Insights into microbial contamination in paddy field ecology: matagenomic analysis of the abundances, diversity, and distribution of antibiotic resistance genes, virulence factors, and their potential bacterial hosts Open
The full text of this preprint has been withdrawn by the authors in order to comply with an institutional policy on preprints. Therefore, the authors do not wish this work to be cited as a reference.
View article: Semaphorin 3D promotes pancreatic ductal adenocarcinoma progression and metastasis through macrophage reprogramming
Semaphorin 3D promotes pancreatic ductal adenocarcinoma progression and metastasis through macrophage reprogramming Open
Axon guidance molecules are frequently altered in pancreatic ductal adenocarcinoma (PDA) and influence PDA progression. However, the molecular mechanism remained unclear. Using genetically engineered mouse models to examine semaphorin 3D (…
View article: WITHDRAWN: Insights into microbial contamination in paddy field ecology: matagenomic analysis of the abundances, diversity, and distribution of antibiotic resistance genes, virulence factors, and their potential bacterial hosts
WITHDRAWN: Insights into microbial contamination in paddy field ecology: matagenomic analysis of the abundances, diversity, and distribution of antibiotic resistance genes, virulence factors, and their potential bacterial hosts Open
Rice cultivation, a vital component of agricultural production, often presents a "high-risk" environment for bacterial antibiotic resistance contamination. This study aims to compare the similarities and differences in antibiotic resistanc…
View article: Overcome the challenge for intratumoral injection of STING agonist for pancreatic cancer by systemic administration
Overcome the challenge for intratumoral injection of STING agonist for pancreatic cancer by systemic administration Open
Due to the challenge for intratumoral administration, innate agonists have not made it beyond preclinical studies for efficacy testing in most tumor types. Pancreatic ductal adenocarcinoma (PDAC) has a hostile tumor microenvironment that r…
View article: Neutrophils in pancreatic ductal adenocarcinoma: bridging preclinical insights to clinical prospects for improved therapeutic strategies
Neutrophils in pancreatic ductal adenocarcinoma: bridging preclinical insights to clinical prospects for improved therapeutic strategies Open
Neutrophils play roles in promoting tumor growth and metastasis in PDAC and are associated with poor prognosis. However, the heterogeneity and plasticity of neutrophils and their complex relationships with other immune cells and extracellu…
View article: Systematic Analysis of DNA Demethylase Gene Families in Foxtail Millet (Setaria italica L.) and Their Expression Variations after Abiotic Stresses
Systematic Analysis of DNA Demethylase Gene Families in Foxtail Millet (Setaria italica L.) and Their Expression Variations after Abiotic Stresses Open
DNA methylation is a highly conserved epigenetic modification involved in many biological processes, including growth and development, stress response, and secondary metabolism. DNA demethylase (DNA-deMTase) genes have been identified in s…
View article: Tumor-derived exosomal ADAM17 promotes pre-metastatic niche formation by enhancing vascular permeability in colorectal cancer
Tumor-derived exosomal ADAM17 promotes pre-metastatic niche formation by enhancing vascular permeability in colorectal cancer Open
Background Hematological metastasis has been recognized as a crucial factor contributing to the high rates of metastasis and mortality observed in colorectal cancer (CRC). Notably, exosomes derived from cancer cells participate in the form…
View article: Neoadjuvant radioimmunotherapy in pancreatic cancer enhances effector T cell infiltration and shortens their distances to tumor cells
Neoadjuvant radioimmunotherapy in pancreatic cancer enhances effector T cell infiltration and shortens their distances to tumor cells Open
Radiotherapy is hypothesized to have an immune-modulating effect on the tumor microenvironment (TME) of pancreatic ductal adenocarcinoma (PDAC) to sensitize it to anti–PD-1 antibody (a–PD-1) treatment. We collected paired pre- and posttrea…
View article: Advances in the treatment of hepatogenous diabetes: A review
Advances in the treatment of hepatogenous diabetes: A review Open
Hepatogenous diabetes (HD) is a glycogen metabolism disorder that arises as a consequence of chronic liver disease. The condition is frequently detected in patients diagnosed with cirrhosis, which is a result of advanced liver disease. The…
View article: Dual-inhibitory domain iCARs improve the efficiency of the AND-NOT gate CAR T strategy
Dual-inhibitory domain iCARs improve the efficiency of the AND-NOT gate CAR T strategy Open
CAR (chimeric antigen receptor) T cell therapy has shown clinical success in treating hematological malignancies, but its treatment of solid tumors has been limited. One major challenge is on-target, off-tumor toxicity, where CAR T cells a…
View article: 1174 Costimulatory IgM T-cell engagers with enhanced and durable cytotoxicity
1174 Costimulatory IgM T-cell engagers with enhanced and durable cytotoxicity Open
Background T-cell engagers (TCEs) have established their therapeutic value in treatment of various cancers by harnessing the power of immune system against tumors in a targeted manner. IgM based TCEs may offer high avidity and safety advan…
View article: Tumor- and Nerve-Derived Axon Guidance Molecule Promotes Pancreatic Ductal Adenocarcinoma Progression and Metastasis through Macrophage Reprogramming
Tumor- and Nerve-Derived Axon Guidance Molecule Promotes Pancreatic Ductal Adenocarcinoma Progression and Metastasis through Macrophage Reprogramming Open
Axon guidance molecules were found to be the gene family most frequently altered in pancreatic ductal adenocarcinoma (PDA) through mutations and copy number changes. However, the exact molecular mechanism regarding PDA development remained…
View article: P815: HIGH VALENCY OF IGM-2644, A CD38XCD3 IGM BISPECIFIC T CELL ENGAGER, DISPLACES DARATUMUMAB BINDING AND INDUCES POTENT MULTIPLE MYELOMA CELL KILLING
P815: HIGH VALENCY OF IGM-2644, A CD38XCD3 IGM BISPECIFIC T CELL ENGAGER, DISPLACES DARATUMUMAB BINDING AND INDUCES POTENT MULTIPLE MYELOMA CELL KILLING Open
Topic: 13. Myeloma and other monoclonal gammopathies - Biology & Translational Research Background: Multiple myeloma (MM) is a common hematologic malignancy characterized by the accumulation of monoclonal plasma cells in the bone marrow. C…
View article: A platform trial of neoadjuvant and adjuvant antitumor vaccination alone or in combination with PD-1 antagonist and CD137 agonist antibodies in patients with resectable pancreatic adenocarcinoma
A platform trial of neoadjuvant and adjuvant antitumor vaccination alone or in combination with PD-1 antagonist and CD137 agonist antibodies in patients with resectable pancreatic adenocarcinoma Open
A neoadjuvant immunotherapy platform clinical trial allows for rapid evaluation of treatment-related changes in tumors and identifying targets to optimize treatment responses. We enrolled patients with resectable pancreatic adenocarcinoma …
View article: Supplementary Methods from Anti-MET ImmunoPET for Non–Small Cell Lung Cancer Using Novel Fully Human Antibody Fragments
Supplementary Methods from Anti-MET ImmunoPET for Non–Small Cell Lung Cancer Using Novel Fully Human Antibody Fragments Open
Supplementary methods not included in the primary manuscript.
View article: Supplementary Methods from Anti-MET ImmunoPET for Non–Small Cell Lung Cancer Using Novel Fully Human Antibody Fragments
Supplementary Methods from Anti-MET ImmunoPET for Non–Small Cell Lung Cancer Using Novel Fully Human Antibody Fragments Open
Supplementary methods not included in the primary manuscript.