Kevin Chai
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View article: Systematic review and meta-analysis of the non-specific and broader impact of respiratory vaccines on acute lower respiratory infections in young children
Systematic review and meta-analysis of the non-specific and broader impact of respiratory vaccines on acute lower respiratory infections in young children Open
Objectives Growing evidence suggests that vaccines targeting respiratory pathogens have non-specific and broader effects. We aimed to investigate the non-specific effects of respiratory vaccines on acute lower respiratory infection (ALRI) …
View article: The economic impact of diabetes: Assessing incremental direct costs in Australia using linked administrative data
The economic impact of diabetes: Assessing incremental direct costs in Australia using linked administrative data Open
Diabetes imposes a substantial excess direct healthcare cost burden. Evidence could guide the planning and allocation of resources, as well as support the need for targeted health interventions.
View article: A systematic review and meta-analysis of circulating 25-hydroxyvitamin D concentration and vitamin D status worldwide
A systematic review and meta-analysis of circulating 25-hydroxyvitamin D concentration and vitamin D status worldwide Open
Background Vitamin D deficiency is a public health concern; however, data on its global prevalence are limited. We reported pooled mean circulating 25-hydroxyvitamin D (25(OH)D) concentration and estimated the prevalence of concentration a…
View article: Indirect evidence of sex-selective abortion practices to the imbalanced sex ratio at birth in Australian migrant populations
Indirect evidence of sex-selective abortion practices to the imbalanced sex ratio at birth in Australian migrant populations Open
A skewed sex ratio at birth (SRB), commonly observed in countries with high son preference can be attributed to prenatal sex-selective abortion. However, the possibility of sex selection among migrants in high-income countries has received…
View article: Survival following psychiatric diagnoses in early adulthood
Survival following psychiatric diagnoses in early adulthood Open
Aims: To establish the increased all-cause mortality risk after an inpatient episode of care with a diagnosis of a severe psychiatric disorder in young people. Methods: The data included all psychiatric inpatient episodes for psychiatric d…
View article: Validity of using a semi-automated screening tool in a systematic review assessing non-specific effects of respiratory vaccines
Validity of using a semi-automated screening tool in a systematic review assessing non-specific effects of respiratory vaccines Open
RS is a valid and reliable tool that reduces the amount of time spent screening articles for large-scale systematic reviews. RS is a useful tool that should be considered for streamlining the process of systematic reviews.
View article: Identification of lipid metabolism related immune markers in atherosclerosis through machine learning and experimental analysis
Identification of lipid metabolism related immune markers in atherosclerosis through machine learning and experimental analysis Open
Background Atherosclerosis is a significant contributor to cardiovascular disease, and conventional diagnostic methods frequently fall short in the timely and accurate detection of early-stage atherosclerosis. Abnormal lipid metabolism pla…
View article: Long-term chronic conditions in individuals with mental and behavioural disorders: A data linkage study
Long-term chronic conditions in individuals with mental and behavioural disorders: A data linkage study Open
Objective: This study aimed to investigate the physical health conditions among health service users in the first year since recorded mental disorder diagnosis in Western Australia. Methods: Community mental health, emergency department (E…
View article: Prevalence of chronic kidney disease in Western Australia, 2010–2020
Prevalence of chronic kidney disease in Western Australia, 2010–2020 Open
Objective To assess the prevalence and trends of chronic kidney disease (CKD) in Western Australia (WA) from 2010 to 2020 using linked pathology data. Design A retrospective observational cohort study using linked de-identified data from W…
View article: Dynamic survival prediction of end-stage kidney disease using random survival forests for competing risk analysis
Dynamic survival prediction of end-stage kidney disease using random survival forests for competing risk analysis Open
Background and hypothesis A static predictive model relying solely on baseline clinicopathological data cannot capture the heterogeneity in predictor trajectories observed in the progression of chronic kidney disease (CKD). To address this…
View article: Estimating the cost of chronic kidney disease in Australia
Estimating the cost of chronic kidney disease in Australia Open
Introduction Chronic kidney disease (CKD) is a significant burden on health systems globally, with limited up-to-date information on health system costs, particularly for non-dialysis patients. This study estimates the direct healthcare co…
View article: E-cigarettes on Instagram: Exploring vape content via anAustralian vaping influencer
E-cigarettes on Instagram: Exploring vape content via anAustralian vaping influencer Open
The findings of this study suggest that pro-vaping information is available and accessible on Instagram. Much of the content identified in this study promoted the purchase or gifting of e-cigarette products and potentially violates Meta's …
View article: Development of a pharmaceutical science systematic review process using a semi‐automated machine learning tool: Intravenous drug compatibility in the neonatal intensive care setting
Development of a pharmaceutical science systematic review process using a semi‐automated machine learning tool: Intravenous drug compatibility in the neonatal intensive care setting Open
Our objective was to establish and test a machine learning‐based screening process that would be applicable to systematic reviews in pharmaceutical sciences. We used the SPIDER (Sample, Phenomenon of Interest, Design, Evaluation, Research …
View article: Critical Windows of Maternal Exposure to Biothermal Stress and Birth Weight for Gestational Age in Western Australia
Critical Windows of Maternal Exposure to Biothermal Stress and Birth Weight for Gestational Age in Western Australia Open
Both weekly and monthly specific extreme biothermal stress exposures showed potential critical susceptible windows of SGA and LGA during late gestational periods with disproportionate sociodemographic vulnerabilities. https://doi.org/10.12…
View article: Protocol for a systematic review of reviews on training primary care providers in dermoscopy to detect skin cancers
Protocol for a systematic review of reviews on training primary care providers in dermoscopy to detect skin cancers Open
Introduction Globally, incidence, prevalence and mortality rates of skin cancers are escalating. Earlier detection by well-trained primary care providers in techniques such as dermoscopy could reduce unnecessary referrals and improve longe…
View article: FIP Brisbane 2023: New Generation of Pharmaceutical Scientists
FIP Brisbane 2023: New Generation of Pharmaceutical Scientists Open
Accepted abstracts under the theme: New Generation of Pharmaceutical Scientists (n=6)
View article: Plain film mandibular fracture detection using machine learning – Model development
Plain film mandibular fracture detection using machine learning – Model development Open
The mandible is the second most fractured bone of the facial skeleton. The most common imaging modality for diagnosis are the Orthopantomogram (OPG) and posterior-anterior mandible (PAM) x-rays. This study was designed to develop a machine…
View article: Promotion of E-Cigarettes on TikTok and Regulatory Considerations
Promotion of E-Cigarettes on TikTok and Regulatory Considerations Open
E-cigarettes are promoted extensively on TikTok and other social media platforms. Platform policies to restrict e-cigarette promotion seem insufficient and are poorly enforced. This paper aims to understand how e-cigarettes are being promo…
View article: Development and validation of a machine learning‐based tool to predict autism among children
Development and validation of a machine learning‐based tool to predict autism among children Open
Autism is a lifelong condition for which intervention must occur as early as possible to improve social functioning. Thus, there is great interest in improving our ability to diagnose autism as early as possible. We take a novel approach t…
View article: Determining cancer stage at diagnosis in population-based cancer registries: A rapid scoping review
Determining cancer stage at diagnosis in population-based cancer registries: A rapid scoping review Open
Introduction Population-based cancer registries are the main source of data for population-level analysis of cancer stage at diagnosis. This data enables analysis of cancer burden by stage, evaluation of screening programs and provides ins…
View article: An impact review of a Western Australian research translation program
An impact review of a Western Australian research translation program Open
The translation gap between knowledge production and implementation into clinical practice and policy is an ongoing challenge facing researchers, funders, clinicians and policy makers globally. Research generated close to practice and in c…
View article: Research Screener: a machine learning tool to semi-automate abstract screening for systematic reviews
Research Screener: a machine learning tool to semi-automate abstract screening for systematic reviews Open
Background Systematic reviews and meta-analyses provide the highest level of evidence to help inform policy and practice, yet their rigorous nature is associated with significant time and economic demands. The screening of titles and abstr…
View article: Stillbirth risk prediction using machine learning for a large cohort of births from Western Australia, 1980–2015
Stillbirth risk prediction using machine learning for a large cohort of births from Western Australia, 1980–2015 Open
Quantification of stillbirth risk has potential to support clinical decision-making. Studies that have attempted to quantify stillbirth risk have been hampered by small event rates, a limited range of predictors that typically exclude obst…
View article: Fluctuation of recent large impact craters rate on Mars from automatic crater detection
Fluctuation of recent large impact craters rate on Mars from automatic crater detection Open
<p>Knowledge of collision rates through time and space is essential because meteoritic impact crater counting is the only way to determine the ages of surface geological units and processes on the solid bodies of our Solar System. Al…