Keyla C. Tumas
YOU?
Author Swipe
View article: NAD activates olfactory receptor 1386 to regulate type I interferon responses in <i>Plasmodium yoelii</i> YM infection
NAD activates olfactory receptor 1386 to regulate type I interferon responses in <i>Plasmodium yoelii</i> YM infection Open
Olfactory receptors (Olfr) are G protein–coupled receptors that are normally expressed on olfactory sensory neurons to detect volatile chemicals or odorants. Interestingly, many Olfrs are also expressed in diverse tissues and function in c…
View article: Dysfunction of CD169 <sup>+</sup> macrophages and blockage of erythrocyte maturation as a mechanism of anemia in <i>Plasmodium yoelii</i> infection
Dysfunction of CD169 <sup>+</sup> macrophages and blockage of erythrocyte maturation as a mechanism of anemia in <i>Plasmodium yoelii</i> infection Open
Plasmodium parasites cause malaria with disease outcomes ranging from mild illness to deadly complications such as severe malarial anemia (SMA), pulmonary edema, acute renal failure, and cerebral malaria. In young children, SMA often requi…
View article: A Plasmodium falciparum RING Finger E3 Ubiquitin Ligase Modifies the Roles of PfMDR1 and PfCRT in Parasite Drug Responses
A Plasmodium falciparum RING Finger E3 Ubiquitin Ligase Modifies the Roles of PfMDR1 and PfCRT in Parasite Drug Responses Open
Protein ubiquitination is an important posttranslational regulation mechanism that mediates Plasmodium development and modifies parasite responses to antimalarial drugs. Although mutations in several parasite ubiquitination enzymes have be…
View article: Long-term stabilization of DNA at room temperature using a one-step microwave assisted process
Long-term stabilization of DNA at room temperature using a one-step microwave assisted process Open
View article: Type I Interferons and Malaria: A Double-Edge Sword Against a Complex Parasitic Disease
Type I Interferons and Malaria: A Double-Edge Sword Against a Complex Parasitic Disease Open
Type I interferons (IFN-Is) are important cytokines playing critical roles in various infections, autoimmune diseases, and cancer. Studies have also shown that IFN-Is exhibit ‘conflicting’ roles in malaria parasite infections. Malaria para…
View article: RTP4 inhibits IFN-I response and enhances experimental cerebral malaria and neuropathology
RTP4 inhibits IFN-I response and enhances experimental cerebral malaria and neuropathology Open
Significance Malaria is a deadly disease affecting hundreds of millions of people. Cerebral malaria is a type of severe disease with a high mortality rate. However, the causes leading to cerebral malaria, likely including parasite and host…
View article: The E3 ubiquitin ligase MARCH1 regulates antimalaria immunity through interferon signaling and T cell activation
The E3 ubiquitin ligase MARCH1 regulates antimalaria immunity through interferon signaling and T cell activation Open
Significance Malaria kills ∼0.4 million people a year. Malaria parasite infection triggers complex immune responses that may control the infection or result in severe disease. The molecular mechanisms underlying host–parasite interaction a…
View article: Plasmodium yoelii Erythrocyte-Binding-like Protein Modulates Host Cell Membrane Structure, Immunity, and Disease Severity
Plasmodium yoelii Erythrocyte-Binding-like Protein Modulates Host Cell Membrane Structure, Immunity, and Disease Severity Open
Malaria is a deadly parasitic disease that continues to afflict hundreds of millions of people every year. Infections with malaria parasites can be asymptomatic, with mild symptoms, or fatal, depending on a delicate balance of host immune …
View article: Detection of host pathways universally inhibited after Plasmodium yoelii infection for immune intervention
Detection of host pathways universally inhibited after Plasmodium yoelii infection for immune intervention Open