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View article: Developing Human Skin Contains Lymphocytes Demonstrating a Memory Signature
Developing Human Skin Contains Lymphocytes Demonstrating a Memory Signature Open
Lymphocytes in barrier tissues play critical roles in host defense and homeostasis. These cells take up residence in tissues during defined developmental windows, when they may demonstrate distinct phenotypes and functions. Here, we utiliz…
View article: Developing human fetal skin demonstrates a unique lymphocyte signature
Developing human fetal skin demonstrates a unique lymphocyte signature Open
Summary Lymphocytes in barrier tissues play critical roles in host defense and homeostasis. These cells take up residence in tissues during defined developmental windows, when they may demonstrate distinct phenotypes and functions. Here, w…
View article: Regulatory T cells use arginase 2 to enhance their metabolic fitness in tissues
Regulatory T cells use arginase 2 to enhance their metabolic fitness in tissues Open
Distinct subsets of Tregs reside in nonlymphoid tissues where they mediate unique functions. To interrogate the biology of tissue Tregs in human health and disease, we phenotypically and functionally compared healthy skin Tregs with those …
View article: Fas ligand promotes an inducible TLR-dependent model of cutaneous lupus–like inflammation
Fas ligand promotes an inducible TLR-dependent model of cutaneous lupus–like inflammation Open
Toll-like receptors TLR7 and TLR9 are both implicated in the activation of autoreactive B cells and other cell types associated with systemic lupus erythematosus (SLE) pathogenesis. However, Tlr9-/- autoimmune-prone strains paradoxically d…
View article: Transcriptional landscape of epithelial and immune cell populations revealed through FACS-seq of healthy human skin
Transcriptional landscape of epithelial and immune cell populations revealed through FACS-seq of healthy human skin Open
Human skin consists of multiple cell types, including epithelial, immune, and stromal cells. Transcriptomic analyses have previously been performed from bulk skin samples or from epithelial and immune cells expanded in cell culture. Howeve…
View article: Tumor immune profiling predicts response to anti–PD-1 therapy in human melanoma
Tumor immune profiling predicts response to anti–PD-1 therapy in human melanoma Open
This work was funded by a generous gift provided by Inga-Lill and David Amoroso as well as a generous gift provided by Stephen Juelsgaard and Lori Cook.