Karen C. Tran
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View article: ĐÁNH GIÁ KẾT QUẢ ĐIỀU TRỊ BƯỚC ĐẦU UNG THƯ ĐƯỜNG MẬT GIAI ĐOẠN TIẾN TRIỂN BẰNG PHÁC ĐỒ GEMCITABINE – CISPLATIN TẠI BỆNH VIỆN K CƠ SỞ TAM HIỆP
ĐÁNH GIÁ KẾT QUẢ ĐIỀU TRỊ BƯỚC ĐẦU UNG THƯ ĐƯỜNG MẬT GIAI ĐOẠN TIẾN TRIỂN BẰNG PHÁC ĐỒ GEMCITABINE – CISPLATIN TẠI BỆNH VIỆN K CƠ SỞ TAM HIỆP Open
Mục tiêu nghiên cứu: Đánh giá kết quả điều trị và mô tả một số tác dụng không mong muốn của phác đồ Gemcitabine-Cisplatin trên bệnh nhân ung thư đường mật giai đoạn tiến triển tại bệnh viện K. Đối tượng và phương pháp nghiên cứu: Nghiên cứ…
View article: The Role of Renal Denervation in the Treatment of Hypertension in Canada: A Case-Based Discussion from the Canadian Hypertension Specialists Society
The Role of Renal Denervation in the Treatment of Hypertension in Canada: A Case-Based Discussion from the Canadian Hypertension Specialists Society Open
Over one-third of Canadians with hypertension do not achieve recommended blood pressure (BP) targets despite availability of effective treatments. Renal sympathetic nerve denervation (RDN) is a recently approved, minimally invasive treatme…
View article: Association between COVID-19 vaccination, SARS-CoV-2 variants, and post COVID-19 condition: A cross-sectional study
Association between COVID-19 vaccination, SARS-CoV-2 variants, and post COVID-19 condition: A cross-sectional study Open
Background Individuals may experience persistent symptoms after recovering from coronavirus disease 2019 (COVID-19), a condition referred to as post COVID-19 condition (PCC). Patient-reported outcome measures (PROMs) evaluate a patient’s h…
View article: Divergent biological pathways distinguish community-acquired pneumonia from COVID-19 despite similar plasma cytokine profiles
Divergent biological pathways distinguish community-acquired pneumonia from COVID-19 despite similar plasma cytokine profiles Open
This case-control study provides insights into cytokine profiles related to CAP and COVID-19 pathogenesis. Although absolute circulating cytokine levels showed no significant differences between the groups, machine learning identified a mo…
View article: Machine Learning Accurately Predicts Need for Critical Care Support in Patients Admitted to Hospital for Community-Acquired Pneumonia
Machine Learning Accurately Predicts Need for Critical Care Support in Patients Admitted to Hospital for Community-Acquired Pneumonia Open
OBJECTIVES: Hospitalized community-acquired pneumonia (CAP) patients are admitted for ventilation, vasopressors, and renal replacement therapy (RRT). This study aimed to develop a machine learning (ML) model that predicts the need for such…
View article: Environmental Dependence of X-Ray Emission From The Least Massive Galaxies
Environmental Dependence of X-Ray Emission From The Least Massive Galaxies Open
The low-mass end of low-mass galaxies is largely unexplored in AGN studies, but it is essential for extending our understanding of the black hole-galaxy coevolution. We surveyed the 3D-HST catalog and collected a sample of 546 dwarf galaxi…
View article: MyGuide long COVID: An online self-management tool for people with long COVID
MyGuide long COVID: An online self-management tool for people with long COVID Open
View article: Health-related adverse work outcomes associated with post COVID-19 condition: a cross-sectional study
Health-related adverse work outcomes associated with post COVID-19 condition: a cross-sectional study Open
Introduction Symptoms from post COVID-19 condition (PCC) can impair functioning in working-age adults. However, there is uncertainty about the relationship between PCC and work outcomes. This study aimed to assess health-related adverse wo…
View article: Complex Thrombo-Inflammatory Responses versus Outcomes of Non-COVID-19 Community-Acquired Pneumonia and COVID-19
Complex Thrombo-Inflammatory Responses versus Outcomes of Non-COVID-19 Community-Acquired Pneumonia and COVID-19 Open
Introduction: The thrombo-inflammatory response and outcomes of community-acquired pneumonia (CAP) due to various organisms (non-COVID-19 CAP) versus CAP due to a single virus, SARS-CoV-2 (i.e., COVID-19) may differ. Methods: Adults hospit…
View article: Community versus academic hospital community-acquired pneumonia patients: a nested cohort study
Community versus academic hospital community-acquired pneumonia patients: a nested cohort study Open
Background Most Canadians receive their care in community hospitals, yet most clinical research is conducted in academic hospitals. This study aims to compare patients with community acquired pneumonia (CAP) treated in academic and communi…
View article: Effects of Losartan on Patients Hospitalized for Acute COVID-19: A Randomized Controlled Trial
Effects of Losartan on Patients Hospitalized for Acute COVID-19: A Randomized Controlled Trial Open
Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) down-regulates angiotensin-converting enzyme 2, potentially increasing angiotensin II. We hypothesized that losartan compared to usual care decreases mortality and is …
View article: Long-Term Health-Related Quality of Life in Working-Age COVID-19 Survivors: A Cross-Sectional Study
Long-Term Health-Related Quality of Life in Working-Age COVID-19 Survivors: A Cross-Sectional Study Open
In working-age adults who have survived >2 years following COVID-19, HRQOL is high among those who never had PCC or have recovered from PCC. However, individuals with ongoing symptoms have lower HRQOL and are more likely to have functional…
View article: Patient-Physician Sex Discordance and “Before Medically Advised” Discharge from Hospital: A Population-Based Retrospective Cohort Study
Patient-Physician Sex Discordance and “Before Medically Advised” Discharge from Hospital: A Population-Based Retrospective Cohort Study Open
View article: Psychiatric Symptoms, Treatment Uptake, and Barriers to Mental Health Care Among US Adults With Post–COVID-19 Condition
Psychiatric Symptoms, Treatment Uptake, and Barriers to Mental Health Care Among US Adults With Post–COVID-19 Condition Open
Importance Psychiatric symptoms are reportedly common among adults with post–COVID-19 condition (PCC). However, nationally representative data regarding symptom prevalence, treatment uptake, and barriers to care are needed to inform the de…
View article: Using a targeted metabolomics approach to explore differences in ARDS associated with COVID-19 compared to ARDS caused by H1N1 influenza and bacterial pneumonia
Using a targeted metabolomics approach to explore differences in ARDS associated with COVID-19 compared to ARDS caused by H1N1 influenza and bacterial pneumonia Open
View article: Myguide Long Covid: An Online Self-Management Tool for People with Long Covid
Myguide Long Covid: An Online Self-Management Tool for People with Long Covid Open
View article: Home Blood Pressure Telemonitoring Technology for Patients With Asymptomatic Elevated Blood Pressure Discharged From the Emergency Department: Pilot Study
Home Blood Pressure Telemonitoring Technology for Patients With Asymptomatic Elevated Blood Pressure Discharged From the Emergency Department: Pilot Study Open
Background Hypertension affects 1 in 5 Canadians and is the leading cause of morbidity and mortality globally. Hypertension control is declining due to multiple factors including lack of access to primary care. Consequently, patients with …
View article: Proteomic Evolution from Acute to Post-COVID-19 Conditions
Proteomic Evolution from Acute to Post-COVID-19 Conditions Open
Many COVID-19 survivors have post-COVID-19 conditions, and females are at a higher risk. We sought to determine (1) how protein levels change from acute to post-COVID-19 conditions, (2) whether females have a plasma protein signature diffe…
View article: A Learning Health System for Long Covid Care and Research in British Columbia
A Learning Health System for Long Covid Care and Research in British Columbia Open
SummaryThere is growing interest in developing outpatient care and research models to support and learn about patients struggling with long-term symptoms following Covid-19 infection (now commonly referred to as long Covid). These patients…
View article: Post-partum maternal bradycardia: A case series and literature review
Post-partum maternal bradycardia: A case series and literature review Open
Background Unlike tachyarrhythmias, which are common in pregnancy, there is a paucity of data regarding maternal bradycardias. Our objective was to describe the characteristics, associated conditions, and prognosis of women who develop bra…
View article: Outcomes and characteristics of patients hospitalized for COVID-19 in British Columbia, Ontario and Quebec during the Omicron wave
Outcomes and characteristics of patients hospitalized for COVID-19 in British Columbia, Ontario and Quebec during the Omicron wave Open
Patients who were at least double vaccinated had lower mortality than unvaccinated patients hospitalized during the Omicron wave. Patients hospitalized during the Omicron wave had more chronic disease and lower mortality than in the first …
View article: Home Blood Pressure Telemonitoring Technology for Patients With Asymptomatic Elevated Blood Pressure Discharged From the Emergency Department: Pilot Study (Preprint)
Home Blood Pressure Telemonitoring Technology for Patients With Asymptomatic Elevated Blood Pressure Discharged From the Emergency Department: Pilot Study (Preprint) Open
BACKGROUND Hypertension affects 1 in 5 Canadians and is the leading cause of morbidity and mortality globally. Hypertension control is declining due to multiple factors including lack of access to primary care. Consequently, patients with…
View article: Use of latent class analysis and patient reported outcome measures to identify distinct long COVID phenotypes: A longitudinal cohort study
Use of latent class analysis and patient reported outcome measures to identify distinct long COVID phenotypes: A longitudinal cohort study Open
Objectives We sought to 1) identify long COVID phenotypes based on patient reported outcome measures (PROMs) and 2) determine whether the phenotypes were associated with quality of life (QoL) and/or lung function. Methods This was a longit…
View article: Post-COVID-19 Condition Characterizing the Burden of Symptoms Using Standardized Assessment
Post-COVID-19 Condition Characterizing the Burden of Symptoms Using Standardized Assessment Open
Background: Systematic evaluation of patients with the post-COVID-19 infections using standardized symptom assessment tools and laboratory testing in the context of clinical care has not been reported previously. Methods: This is a cohort …
View article: D-Dimer Elevation and Venous Thromboembolism ≥90 Days following COVID-19
D-Dimer Elevation and Venous Thromboembolism ≥90 Days following COVID-19 Open
Background: In acute COVID-19, plasma D-Dimer is a useful biomarker and venous thromboembolism (VTE) is common. However, it is less clear whether this is the case during long-term recovery. Objectives: To report D-Dimer values and incidenc…
View article: Table of Contents
Table of Contents Open
View article: Implementation of a home blood pressure monitoring program for the management of hypertensive disorders of pregnancy, an observational study in British Columbia, Canada
Implementation of a home blood pressure monitoring program for the management of hypertensive disorders of pregnancy, an observational study in British Columbia, Canada Open
Background COVID-19 pandemic has influenced health care delivery. We conducted an observational study to understand how obstetric medicine (ObM) physicians utilized home blood pressure monitoring (HBPM) to manage hypertension in pregnancy.…
View article: Cardiovascular Considerations in the Management of People With Suspected Long COVID
Cardiovascular Considerations in the Management of People With Suspected Long COVID Open
View article: Evaluating fatigue in patients recovering from COVID-19: validation of the fatigue severity scale and single item screening questions
Evaluating fatigue in patients recovering from COVID-19: validation of the fatigue severity scale and single item screening questions Open
View article: Hospital Admission and Hospital Course Predictors of Severity of Post-covid-19 Condition
Hospital Admission and Hospital Course Predictors of Severity of Post-covid-19 Condition Open
BACKGROUND Prediction of severity of Post-COVID-19 condition is not clear. We determined whether hospital course variables correlated with objective and subjective outcomes 3- and 6-months post-COVID-19 onset. METHODS Adults admitted to ho…