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View article: Glutamatergic dysfunction precedes neuron loss in cerebral organoids with<i>MAPT</i>mutation
Glutamatergic dysfunction precedes neuron loss in cerebral organoids with<i>MAPT</i>mutation Open
SUMMARY Frontotemporal dementia (FTD) due to MAPT mutation causes pathological accumulation of tau and glutamatergic cortical neuronal death by unknown mechanisms. We used human induced pluripotent stem cell (iPSC)-derived cerebral organoi…
View article: A Comprehensive Resource for Induced Pluripotent Stem Cells from Patients with Primary Tauopathies
A Comprehensive Resource for Induced Pluripotent Stem Cells from Patients with Primary Tauopathies Open
Primary tauopathies are characterized neuropathologically by inclusions containing abnormal forms of the microtubule-associated protein tau (MAPT) and clinically by diverse neuropsychiatric, cognitive, and motor impairments. Autosomal domi…
View article: tRNA Modification Detection Using Graphene Nanopores: A Simulation Study
tRNA Modification Detection Using Graphene Nanopores: A Simulation Study Open
There are over 100 enzyme-catalyzed modifications on transfer RNA (tRNA) molecules. The levels and identity of wobble uridine (U) modifications are affected by environmental conditions and diseased states, making wobble U detection a poten…