Explanipedia

Microalgae-Derived Peptides Targeting Lifestyle-Related Diseases: Discovery, Mechanisms, Structure–Activity Relationships, and Structural Modifications Open

Mohammed S. Qoms, Sok Kuan Wong, Norsyahida Mohd Fauzi, Khairana Husain, Suzana Makpol , et al. · 2025

Microalgae are an emerging source of bioactive peptides with promising therapeutic potential against lifestyle-related diseases such as oxidative stress-related conditions, hypertension, diabetes, and obesity. While numerous studies have i…

Review of Online Pharmacy Learning Approaches Open

Eric Wen, Khairana Husain, Jamia Azdina Jamal, Juriyati Jalil · 2025

Sejak beberapa tahun kebelakangan ini, pembelajaran dalam talian (OL) telah muncul sebagai kaedah yang dinamik dan inovatif untuk menyampaikan ilmu pengajaran dengan lebih efektif di institusi pengajian tinggi (IPT), termasuk dalam bidang …

Phytoconstituents and pharmacological activities of Mitrephora species (Annonaceae): a review Open

Juriyati Jalil, Muhammad Afiq, Shafizi Abdul Wahab, Khairana Husain · 2025

This study reviewed the phytoconstituents and pharmacological properties of 13 Mitrephora species, namely, Mitrephora alba Ridl., Mitrephora celebica Scheff., Mitrephora diversifolia (Span.) Miq., Mitrephora glabra Scheff., Mitrephora heyn…

10019: Christia vespertilionis (L.f.) Bakh. F. Leaves Inhibits Early Atherogenesis: An In Vitro study Open

Norsyahida Mohd Fauzi, Ning Tan, Khairana Husain, Zakiah Jubri, Kok Meng Chan , et al. · 2024

Design and Characterisation of Curcumin-Loaded Nanostructured Lipid Carriers for Safe and Efficient Topical Drug Delivery in The Treatment of Pressure Ulcer Open

Nur Amira Mohd. Shamsuddin, Fazren Azmi, Khairana Husain, Lek Mun Leong, Mohd Hanif Zulfakar · 2024

Pressure ulcers (PU) are chronic lesions with a high prevalence in at-risk populations. Although curcumin has various therapeutic properties, its use as a dermal therapeutic agent is limited by its poor solubility and permeability. This st…

Phytochemical profile and diverse pharmacology of Garcinia celebica L Open

Nor Hidayah Mustafa, Juriyati Jalil, Kai En Leong, Jamia Azdina Jamal, Khairana Husain · 2024

Garcinia celebica L. syn. Garcinia hombroniana Pierre belongs to the family Clusiaceae, is indigenous to Southeast Asian countries. This review aims to provide updated, comprehensive and categorized information on the phytoco…

Anti-Atherogenic Mechanism of Ethanolic Extract of Christia Vespertilionis (L.F.) Bakh. F. Leaves in Vitro Open

Jiah Ning Tan, Khairana Husain, Zakiah Jubri, Kok Meng Chan, Azizah Ugusman , et al. · 2024

Antiperspirant and Antibacterial Activities of Curcuma xanthorrhiza Extract as a Potential Alternative Treatment for Hyperhidrosis Open

Nurliyana Athirah Md Sidek, Khairana Husain, Fhataheya Buang, Mazlina Mohd Said · 2023

Hyperhidrosis is a condition characterized by excessive sweating that affects at least 5% of the world’s population. It is normally associated with unpleasant body odour which requires continuous maintenance throughout life. Antiperspirant…

Pharmacological activities and mechanisms of action of hypophyllanthin: A review Open

Wan Azmira Wan Saidin, Ibrahim Jantan, Siti Mariam Abdul Wahab, Juriyati Jalil, Mazlina Mohd Said , et al. · 2023

Hypophyllanthin is a major lignan present in various Phyllanthus species and has been used as one of the bioactive chemical markers for quality control purposes as it contributes to their diverse pharmacological activities. The objective o…

The Effects of the Fractions of Piper sarmentosum Leaves on Inhibition of Adipogenesis of 3T3 L1 Preadipocytes Open

Fairus Ahmad, Ima Nirwana Soelaiman, Khairana Husain, Farihah Hj Suhaimi, Kien Hui Chua , et al. · 2022

Piper sarmentosum Roxb. was reported to have anti-obesity, hypoglycaemic and anti-oxidant properties. The aim of this study was to identify the fractions of P. sarmentosum leaf extract in inhibiting adipogenesis of 3T3L1 preadipocytes. The…

Genistein: A Review on its Anti-Inflammatory Properties Open

Yu Xian Goh, Juriyati Jalil, Kok Wai Lam, Khairana Husain, Chandini Menon Premakumar · 2022

Nowadays, non-resolving inflammation is becoming a major trigger in various diseases as it plays a significant role in the pathogenesis of atherosclerosis, asthma, cancer, obesity, inflammatory bowel disease, chronic obstructive pulmonary …

<i>Gynura Procumbens</i> (Lour.) Merr. Extract Attenuates Monocyte Adherence to Endothelial Cell Through Suppression of the NF-κB Signaling Pathway Open

Jiah Ning Tan, Khairana Husain, Zakiah Jubri, Kok Meng Chan, Ibrahim Jantan , et al. · 2022

Demethylbelamcandaquinone B from Marantodes pumilum var. alata (Blume) Kuntze inhibits osteoclast differentiation in RAW264.7 cells Open

Haryati Ahmad Hairi, Jamia Azdina Jamal, Nor Ashila Aladdin, Khairana Husain, Noor Suhaili Mohd Sofi , et al. · 2021

Objective: To investigate the bone-resorbing effect of demethylbelamcandaquinone B (Dmcq B) extracted from Marantodes pumilum var. alata on osteoclast differentiation in RAW264.7 cells. Methods: RAW264.7 macrophages were differentiated usi…

Anti-Allergic Rhinitis Effects of Medicinal Plants and Their Bioactive Metabolites via Suppression of the Immune System: A Mechanistic Review Open

Nur Amira Rahim, Ibrahim Jantan, Mazlina Mohd Said, Juriyati Jalil, Amirul Faiz Abd Razak , et al. · 2021

Allergic rhinitis (AR) is a common inflammatory condition of the nasal mucosa and it is an immunoglobulin E–mediated disease. The incidence and prevalence of AR globally have been escalating over recent years. Antihistamines, intranasal co…

Mechanistic Studies of the Antiallergic Activity of Phyllanthus amarus Schum. & Thonn. and Its Compounds Open

Nur Zahirah Abd Rani, Kok Wai Lam, Juriyati Jalil, Hazni Falina Mohamad, Mohd Shukri Mat Ali , et al. · 2021

Phyllanthus amarus Schum. & Thonn. (Phyllanthaceae) is a medicinal plant that is commonly used to treat diseases such as asthma, diabetes, and anemia. This study aimed to examine the antiallergic activity of P. amarus extract and its compo…

Sinensetin: An Insight on Its Pharmacological Activities, Mechanisms of Action and Toxicity Open

Lee Han Jie, Ibrahim Jantan, Syaratul Dalina Yusoff, Juriyati Jalil, Khairana Husain · 2021

Sinensetin, a plant-derived polymethoxylated flavonoid found in Orthosiphon aristatus var. aristatus and several citrus fruits, has been found to possess strong anticancer activities and a variety of other pharmacological benefits and prom…

Exploring the Antibacterial Potential of Traditional Plants for Body Odor Control Open

Nurliyana Athirah Md Sidek, Barry Van Der Berg, Khairana Husain, Mazlina Mohd Said · 2021

Antioxidant and Anti-Inflammatory Effects of Genus Gynura: A Systematic Review Open

Jiah Ning Tan, Shamin Mohd Saffian, Fhataheya Buang, Zakiah Jubri, Ibrahim Jantan , et al. · 2020

Background: Gynura species have been used traditionally to treat various ailments, such as fever, pain, and to control blood glucose level. This systematic review critically discusses studies regarding Gynura species that exhibited antioxi…

Xanthine oxidase inhibitory activity of a new isocoumarin obtained from Marantodes pumilum var. pumila leaves Open

Nor-Ashila Aladdin, Khairana Husain, Juriyati Jalil, Carla Wulandari Sabandar, Jamia Azdina Jamal · 2020

A Review on the Potential Use of Medicinal Plants From Asteraceae and Lamiaceae Plant Family in Cardiovascular Diseases Open

Jennifer Carlisle Michel, Nur Zahirah Abd Rani, Khairana Husain · 2020

Cardiovascular diseases are one of the most prevalent diseases worldwide, and its rate of mortality is rising annually. In accordance with the current condition, studies on medicinal plants upon their activity on cardiovascular diseases ar…

Inhibition of the Chemiluminescence and Chemotactic Activity of Phagocytes for Selected Ficus Species Extract and Their Lipoxygenase and Xanthine Oxidase Enzyme Inhibitory Open

Shukranul Mawa, Ibrahim Jantan, Fadzureena Jamaluddin, Khairana Husain · 2020

The monetary policy framework is one of the influencing factors of the economy. The energy sector like all other sectors of the economy is influenced by the monetary policy. Thus, the impact of monetary policy on sustainable energy financi…

Anti-hyperuricemic and Anti-inflammatory Effects of Marantodes pumilum as Potential Treatment for Gout Open

Eldiza Puji Rahmi, Endang Kumolosasi, Juriyati Jalil, Khairana Husain, Fhataheya Buang , et al. · 2020

Marantodes pumilum (Primulaceae) has been used in Malaysian folk medicine to help women regain strength after delivery and for "sickness in the bones." It was previously revealed that its extracts inhibited xanthine oxidase (XO) act…

In vitro anti-allergic activity of Moringa oleifera Lam. extracts and their isolated compounds Open

Nur Zahirah Abd Rani, Endang Kumolosasi, Malina Jasamai, Jamia Azdina Jamal, Kok Wai Lam , et al. · 2019

<i>Gynura procumbens</i> Standardised Extract Reduces Cholesterol Levels and Modulates Oxidative Status in Postmenopausal Rats Fed with Cholesterol Diet Enriched with Repeatedly Heated Palm Oil Open

Khuzaidatul Azidah Ahmad Nazri, Norsyahida Mohd Fauzi, Fhataheya Buang, Qodriyah Haji Mohd Saad, Khairana Husain , et al. · 2019

Gynura procumbens (Lour.) Merr. (GP) has been reported in previous studies to possess antihyperlipidaemic, antioxidative, and cardioprotective properties. This study was aimed to determine the effect of standardised 80% ethanol extract of …

Lamiaceae: An Insight on Their Anti-Allergic Potential and Its Mechanisms of Action Open

Lee Yen Sim, Nur Zahirah Abd Rani, Khairana Husain · 2019

The prevalence of allergic diseases such as asthma, allergic rhinitis, food allergy and atopic dermatitis has increased dramatically in recent decades. Conventional therapies for allergy can induce undesirable effects and hence patients te…

Raging the War Against Inflammation With Natural Products Open

Ali Attiq, Juriyati Jalil, Khairana Husain, Waqas Ahmad · 2018

Over the last few decade Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) are the drugs of choice for treating numerous inflammatory diseases including rheumatoid arthritis. The NSAIDs produces anti-inflammatory activity via inhibiting cyclo…

Demethylbelamcandaquinone B (Dmcq B) Is the Active Compound of Marantodes pumilum var. alata (Blume) Kuntze with Osteoanabolic Activities Open

Haryati Ahmad Hairi, Jamia Azdina Jamal, Nor Ashila Aladdin, Khairana Husain, Noor Suhaili Mohd Sofi , et al. · 2018

Phytoestrogens have attracted considerable attention for their potential in the prevention of postmenopausal osteoporosis. Recently, a phytoestrogen-rich herbal plant, Marantodes pumilum var. alata (Blume) Kuntze was reported to protect ag…

Zingiber zerumbet L. (Smith) extract alleviates the ethanol-induced brain damage via its antioxidant activity Open

Asmah Hamid, Farah Wahida Ibrahim, Teoh Hooi Ming, Mohd Nazir Nasrom, Norelina Eusoff , et al. · 2018

Moringa Genus: A Review of Phytochemistry and Pharmacology Open

Nur Zahirah Abd Rani, Khairana Husain, Endang Kumolosasi · 2018

Moringa is a genus of medicinal plants that has been used traditionally to cure wounds and various diseases such as colds and diabetes. In addition, the genus is also consumed as a source of nutrients and widely used for purifying w…

Annonaceae: Breaking the Wall of Inflammation Open

Ali Attiq, Juriyati Jalil, Khairana Husain · 2017

Inventories of tropical forests have listed Annonaceae as one of the most diverse plant families. For centuries, it is employed in traditional medicines to cure various pathological conditions including snakebite, analgesic, astringent, di…

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