Khaled A. Hassan
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View article: The Awareness and Perceptions of Radiotherapy and Their Impact on the Usage of Radiotherapy in Saudi Arabia
The Awareness and Perceptions of Radiotherapy and Their Impact on the Usage of Radiotherapy in Saudi Arabia Open
Background: Cancer is a significant public health challenge worldwide, and Saudi Arabia is no exception. The effective treatment of cancer, particularly in its advanced stages, often involves the use of radiotherapy, a critical component o…
View article: Six-Year Outcomes Following Stereotactic Body Radiation Therapy for Insulinoma: A Case Report and Literature Review
Six-Year Outcomes Following Stereotactic Body Radiation Therapy for Insulinoma: A Case Report and Literature Review Open
Insulinomas are the most prevalent hormone-producing pancreatic neuroendocrine neoplasms (panNEN). Surgical resection of these tumors is frequently curative and is currently the mainstay treatment for preventing long-term brain damage caus…
View article: Long-Term Outcomes of Extensive-Stage Small Cell Lung Cancer Treated with Chemotherapy or Chemo-Immunotherapy: A Propensity Score Adjusted Cohort Study
Long-Term Outcomes of Extensive-Stage Small Cell Lung Cancer Treated with Chemotherapy or Chemo-Immunotherapy: A Propensity Score Adjusted Cohort Study Open
View article: Direct Oral Anticoagulants Versus Warfarin in Patients With Isolated Heparin‐Induced Thrombocytopenia or Heparin‐Induced Thrombocytopenia With Thrombosis
Direct Oral Anticoagulants Versus Warfarin in Patients With Isolated Heparin‐Induced Thrombocytopenia or Heparin‐Induced Thrombocytopenia With Thrombosis Open
No existing studies compare oral anticoagulants to treat heparin‐induced thrombocytopenia with or without thrombosis (HIT/HITT). This retrospective study evaluated thrombotic and bleeding outcomes in adults treated for HIT/HITT with a dire…
View article: Management of Pulmonary Toxicities Associated with Systemic Therapy in Non Small Cell Lung Cancer
Management of Pulmonary Toxicities Associated with Systemic Therapy in Non Small Cell Lung Cancer Open
View article: MUC1-C: The Occam Razor of Osimertinib Resistance?
MUC1-C: The Occam Razor of Osimertinib Resistance? Open
View article: Clinical Outcomes With Pembrolizumab-Based Therapies in Recurrent/Refractory NSCLC After Chemoradiation and Consolidative Durvalumab
Clinical Outcomes With Pembrolizumab-Based Therapies in Recurrent/Refractory NSCLC After Chemoradiation and Consolidative Durvalumab Open
View article: Supplementary Figures 1-4 from Notch Reporter Activity in Breast Cancer Cell Lines Identifies a Subset of Cells with Stem Cell Activity
Supplementary Figures 1-4 from Notch Reporter Activity in Breast Cancer Cell Lines Identifies a Subset of Cells with Stem Cell Activity Open
Supplemental Figure 1. Notch4 mRNA expression correlates with Notch ligands and downstream effectors; Supplemental Figure 2. A schematic outline of experimental procedures; Supplemental Figure 3. A single Notch+ cell has the capacity to ge…
View article: Data from Notch Reporter Activity in Breast Cancer Cell Lines Identifies a Subset of Cells with Stem Cell Activity
Data from Notch Reporter Activity in Breast Cancer Cell Lines Identifies a Subset of Cells with Stem Cell Activity Open
Developmental pathways such as Notch play a pivotal role in tissue-specific stem cell self-renewal as well as in tumor development. However, the role of Notch signaling in breast cancer stem cells (CSC) remains to be determined. We utilize…
View article: Supplementary Figures 1-4 from Notch Reporter Activity in Breast Cancer Cell Lines Identifies a Subset of Cells with Stem Cell Activity
Supplementary Figures 1-4 from Notch Reporter Activity in Breast Cancer Cell Lines Identifies a Subset of Cells with Stem Cell Activity Open
Supplemental Figure 1. Notch4 mRNA expression correlates with Notch ligands and downstream effectors; Supplemental Figure 2. A schematic outline of experimental procedures; Supplemental Figure 3. A single Notch+ cell has the capacity to ge…
View article: Data from Notch Reporter Activity in Breast Cancer Cell Lines Identifies a Subset of Cells with Stem Cell Activity
Data from Notch Reporter Activity in Breast Cancer Cell Lines Identifies a Subset of Cells with Stem Cell Activity Open
Developmental pathways such as Notch play a pivotal role in tissue-specific stem cell self-renewal as well as in tumor development. However, the role of Notch signaling in breast cancer stem cells (CSC) remains to be determined. We utilize…
View article: Supplementary Methods from Notch Pathway Activity Identifies Cells with Cancer Stem Cell–like Properties and Correlates with Worse Survival in Lung Adenocarcinoma
Supplementary Methods from Notch Pathway Activity Identifies Cells with Cancer Stem Cell–like Properties and Correlates with Worse Survival in Lung Adenocarcinoma Open
PDF file - 84K, Immunohistochemistry and PCR assays methodology.
View article: Supplementary Figure 2 from Notch Pathway Activity Identifies Cells with Cancer Stem Cell–like Properties and Correlates with Worse Survival in Lung Adenocarcinoma
Supplementary Figure 2 from Notch Pathway Activity Identifies Cells with Cancer Stem Cell–like Properties and Correlates with Worse Survival in Lung Adenocarcinoma Open
PDF file - 357K, NSCLC cell lines transduced with Notch reporter.
View article: Supplementary Figure 6 from Notch Pathway Activity Identifies Cells with Cancer Stem Cell–like Properties and Correlates with Worse Survival in Lung Adenocarcinoma
Supplementary Figure 6 from Notch Pathway Activity Identifies Cells with Cancer Stem Cell–like Properties and Correlates with Worse Survival in Lung Adenocarcinoma Open
PDF file - 467K, Representative immunohistochemical staining for Hes-1 protein, in primary NSCLC tissue micro array and NCI-H1299 xenograft.
View article: Supplementary Figure 6 from Notch Pathway Activity Identifies Cells with Cancer Stem Cell–like Properties and Correlates with Worse Survival in Lung Adenocarcinoma
Supplementary Figure 6 from Notch Pathway Activity Identifies Cells with Cancer Stem Cell–like Properties and Correlates with Worse Survival in Lung Adenocarcinoma Open
PDF file - 467K, Representative immunohistochemical staining for Hes-1 protein, in primary NSCLC tissue micro array and NCI-H1299 xenograft.
View article: Supplementary Figure 3 from Notch Pathway Activity Identifies Cells with Cancer Stem Cell–like Properties and Correlates with Worse Survival in Lung Adenocarcinoma
Supplementary Figure 3 from Notch Pathway Activity Identifies Cells with Cancer Stem Cell–like Properties and Correlates with Worse Survival in Lung Adenocarcinoma Open
PDF file - 82K, Relative expression of Notch receptors and ligands in multiple NSCLC cell lines transduced with Notch reporter.
View article: Supplementary Table 1 from Notch Pathway Activity Identifies Cells with Cancer Stem Cell–like Properties and Correlates with Worse Survival in Lung Adenocarcinoma
Supplementary Table 1 from Notch Pathway Activity Identifies Cells with Cancer Stem Cell–like Properties and Correlates with Worse Survival in Lung Adenocarcinoma Open
PDF file - 76K, Clinical variables of the lung adenocarcinoma patients.
View article: Supplementary Methods from Notch Pathway Activity Identifies Cells with Cancer Stem Cell–like Properties and Correlates with Worse Survival in Lung Adenocarcinoma
Supplementary Methods from Notch Pathway Activity Identifies Cells with Cancer Stem Cell–like Properties and Correlates with Worse Survival in Lung Adenocarcinoma Open
PDF file - 84K, Immunohistochemistry and PCR assays methodology.
View article: Data from The EGFR T790M Mutation Is Acquired through AICDA-Mediated Deamination of 5-Methylcytosine following TKI Treatment in Lung Cancer
Data from The EGFR T790M Mutation Is Acquired through AICDA-Mediated Deamination of 5-Methylcytosine following TKI Treatment in Lung Cancer Open
Almost all patients with EGFR-driven lung cancer who are treated with EGFR tyrosine kinase inhibitors (TKI) develop resistance to treatment. A single base (c.2369C>T) transition mutation, EGFR T790M, is the most frequent resistance …
View article: Supplementary Figure 7 from Notch Pathway Activity Identifies Cells with Cancer Stem Cell–like Properties and Correlates with Worse Survival in Lung Adenocarcinoma
Supplementary Figure 7 from Notch Pathway Activity Identifies Cells with Cancer Stem Cell–like Properties and Correlates with Worse Survival in Lung Adenocarcinoma Open
PDF file - 59K, Notch1 receptor mutation analysis in multiple NSCLC cell lines.
View article: Supplementary Figure 2 from Notch Pathway Activity Identifies Cells with Cancer Stem Cell–like Properties and Correlates with Worse Survival in Lung Adenocarcinoma
Supplementary Figure 2 from Notch Pathway Activity Identifies Cells with Cancer Stem Cell–like Properties and Correlates with Worse Survival in Lung Adenocarcinoma Open
PDF file - 357K, NSCLC cell lines transduced with Notch reporter.
View article: Data from Notch Pathway Activity Identifies Cells with Cancer Stem Cell–like Properties and Correlates with Worse Survival in Lung Adenocarcinoma
Data from Notch Pathway Activity Identifies Cells with Cancer Stem Cell–like Properties and Correlates with Worse Survival in Lung Adenocarcinoma Open
Purpose: The cancer stem cell theory postulates that tumors contain a subset of cells with stem cell properties of self-renewal, differentiation, and tumor initiation. The purpose of this study is to determine the role of Notch acti…
View article: Supplementary Tables S1-S2 from An Embryonic Stem Cell–Like Signature Identifies Poorly Differentiated Lung Adenocarcinoma but not Squamous Cell Carcinoma
Supplementary Tables S1-S2 from An Embryonic Stem Cell–Like Signature Identifies Poorly Differentiated Lung Adenocarcinoma but not Squamous Cell Carcinoma Open
Supplementary Tables S1-S2 from An Embryonic Stem Cell–Like Signature Identifies Poorly Differentiated Lung Adenocarcinoma but not Squamous Cell Carcinoma
View article: Supplementary Figure 3 from The EGFR T790M Mutation Is Acquired through AICDA-Mediated Deamination of 5-Methylcytosine following TKI Treatment in Lung Cancer
Supplementary Figure 3 from The EGFR T790M Mutation Is Acquired through AICDA-Mediated Deamination of 5-Methylcytosine following TKI Treatment in Lung Cancer Open
APOBEC and AICDA expression after exposure to gefitinb.
View article: Supplementary Table 2 from Notch Pathway Activity Identifies Cells with Cancer Stem Cell–like Properties and Correlates with Worse Survival in Lung Adenocarcinoma
Supplementary Table 2 from Notch Pathway Activity Identifies Cells with Cancer Stem Cell–like Properties and Correlates with Worse Survival in Lung Adenocarcinoma Open
PDF file - 90K, Notch pathway genes categorized based on function.
View article: Supplementary Figure 4 from The EGFR T790M Mutation Is Acquired through AICDA-Mediated Deamination of 5-Methylcytosine following TKI Treatment in Lung Cancer
Supplementary Figure 4 from The EGFR T790M Mutation Is Acquired through AICDA-Mediated Deamination of 5-Methylcytosine following TKI Treatment in Lung Cancer Open
AICDA and RELB expression after TKI exposure was inhibited upon pretreatment with BAY11-7802.
View article: Supplementary Figure 1 from Notch Pathway Activity Identifies Cells with Cancer Stem Cell–like Properties and Correlates with Worse Survival in Lung Adenocarcinoma
Supplementary Figure 1 from Notch Pathway Activity Identifies Cells with Cancer Stem Cell–like Properties and Correlates with Worse Survival in Lung Adenocarcinoma Open
PDF file - 196K, Stable transduction of NCI-H1299 with Notch reporter, where GFP-bright cells regenerate GFP-dim cells, while GFP-dim cells are unable to generate GFP-bright cells.
View article: Supplementary Table 2 from The EGFR T790M Mutation Is Acquired through AICDA-Mediated Deamination of 5-Methylcytosine following TKI Treatment in Lung Cancer
Supplementary Table 2 from The EGFR T790M Mutation Is Acquired through AICDA-Mediated Deamination of 5-Methylcytosine following TKI Treatment in Lung Cancer Open
A) Cytosine Methylation Status by Mass Spectrometry.
View article: Supplementary Table 1 from Notch Pathway Activity Identifies Cells with Cancer Stem Cell–like Properties and Correlates with Worse Survival in Lung Adenocarcinoma
Supplementary Table 1 from Notch Pathway Activity Identifies Cells with Cancer Stem Cell–like Properties and Correlates with Worse Survival in Lung Adenocarcinoma Open
PDF file - 76K, Clinical variables of the lung adenocarcinoma patients.
View article: Supplementary Table 1 from The EGFR T790M Mutation Is Acquired through AICDA-Mediated Deamination of 5-Methylcytosine following TKI Treatment in Lung Cancer
Supplementary Table 1 from The EGFR T790M Mutation Is Acquired through AICDA-Mediated Deamination of 5-Methylcytosine following TKI Treatment in Lung Cancer Open
Patients' clinical data.