Khaled Hached
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View article: ENSA and ARPP19 differentially control cell cycle progression and development
ENSA and ARPP19 differentially control cell cycle progression and development Open
Greatwall (GWL) is an essential kinase that indirectly controls PP2A-B55, the phosphatase counterbalancing cyclin B/CDK1 activity during mitosis. In Xenopus laevis egg extracts, GWL-mediated phosphorylation of overexpressed ARPP19 and ENSA…
View article: Ensa controls S-phase length by modulating Treslin levels
Ensa controls S-phase length by modulating Treslin levels Open
The Greatwall/Ensa/PP2A-B55 pathway is essential for controlling mitotic substrate phosphorylation and mitotic entry. Here, we investigate the effect of the knockdown of the Gwl substrate, Ensa, in human cells. Unexpectedly, Ensa knockdown…
View article: The master Greatwall kinase, a critical regulator of mitosis and meiosis
The master Greatwall kinase, a critical regulator of mitosis and meiosis Open
Entry into mitosis requires the coordinated activation of various protein kinases and phosphatases that together activate sequential signaling pathways allowing entry, progression and exit of mitosis. The limiting step is thought to be the…