Explanipedia

Acid β-glucosidase (GBA1) gene mutational spectrum and clinical phenotypes in patients with gaucher disease: seven novel mutations in a multicenter retrospective cohort study from upper Egypt Open

Mervat A. M. Youssef, Solaf M. Elsayed, Khalid I. Elsayh, Sherin A. Taha, Hala S M Abdelmotogaly , et al. · 2025

Background This study aimed to identify GBA1 variants in Egyptian Gaucher disease (GD) patients residing in a region with high consanguinity and to correlate these genotypes with their clinical phenotypes. Methodology This descriptive stud…

Epidemiological and clinical characteristics of children and young adults with Glanzmann’s thrombasthenia in upper Egypt: a multicenter cross-sectional study Open

Gehan Lotfy Abdel Hakeem, Ahmed El-Sayed, Zahraa Elmasry, Khalid I. Elsayh, Zizi T. Atwa , et al. · 2025

Detection and characterization of autoreactive memory stem T-cells in children with acute immune thrombocytopenia Open

Asmaa M. Zahran, Omnia El‐Badawy, Hayam Mahran, Eman F. Gad, Khaled Saad , et al. · 2024

Clinical signs and treatment of New-onset Bone marrow failure associated SARS-CoV-2 infection in Children : a single institution prospective cohort study . Open

Mervat A. M. Youssef, Ebtisam Shawky Hmed, Dalia Tarik Kamal, Khalid I. Elsayh, Mai A Abdelfatta , et al. · 2024

Viral infections can cause direct and indirect damage to hematopoietic stem cells. The objectives of this study were to identify the frequency and severity of aplastic anemia in Severe acute respiratory syndrome coronavirus 2 ( SARS-CoV-2…

Could the Crosstalk Between Myeloid-Derived-Suppressor Cells and Regulatory T Cells Have a Role in Beta-Thalassemia? Open

Asmaa M. Zahran, Omnia El‐Badawy, Eman R. Badawy, Khalid I. Elsayh, Eman F. Gad , et al. · 2023

Levels of Tregs and MDSCs increased in TDT and may probably have a role in suppressing the active immune systems of TDT patients.

Upregulation of Cytotoxic T-cells in pediatric patients with Gaucher disease Open

Asmaa M. Zahran, Khaled Saad, Khalid I. Elsayh, Madleen Adel A. Abdou, Amir M. Abo-Elgheet , et al. · 2022

Cytotoxic (CD8) T-cells and natural killer (NK) cells have a significant immune function role. The ongoing stimulation of immunity and the excessive release of proinflammatory cytokines observed in pediatric patients with Gaucher disease (…

Regulatory T-lymphocyte subsets in children with chronic immune thrombocytopenia after high-dose of dexamethasone Open

Khalid I. Elsayh, Khaled Saad, Naglaa S. Osman, Khaled Hashim Mahmoud, Faisal Alkhateeb Ahmad , et al. · 2022

Background Immune thrombocytopenia (ITP) is an acquired autoimmune disease. This study’s objective was to estimate the variations in the population of CD4 + CD25 +High FoxP3 + cells (CD4 + regulatory T-lymphocytes; Tregs) in previously unt…

Increase in polymorphonuclear myeloid-derived suppressor cells and regulatory T-cells in children with B-cell acute lymphoblastic leukemia Open

Asmaa M. Zahran, Azza Shibl, Amal Rayan, Mohamed Alaa Eldeen Hassan Mohamed, Amira Osman , et al. · 2021

Genotyping versus phenotyping of non-ABO erythrocyte antigens in patients with the Mediterranean hemopathic syndromes: Effect of transfusion therapy Open

Eman NasrEldin, Safaa A. A. Khaled, Nada O. Abdelhameed, Maha M. Atwa, Marwa M. Thabet , et al. · 2021

The Mediterranean hemopathic syndromes (MHS) are the most prevalent hemoglobinopathies in the Mediterranean basin. Transfusion therapy is the main therapy for these disorders, particularly for severe forms of the disease. Currently, pre-tr…

Could the Crosstalk Between Mdscs and Tregs Have a Role in β-thalassemia? Open

Asmaa M. Zahran, Omnia El‐Badawy, Eman R. Badawy, Marwa Ghazaly, Khaled Saad , et al. · 2021

Background: Secondary-iron overload, alloimmunization, and increased risk of infections are common complications in β-thalassemia major (BTM) patients. Tregs and myeloid-derived suppressor cells (MDSCs) play an essential role in preventing…

Wheat bran as a natural remedy for COVID-19 Open

Khalid I. Elsayh, Omnia El‐Badawy, Khaled Saad, Asmaa M. Zahran · 2020

COVID-19 severity is not only due to the viral infection but also due to the host immune responses.Destructive inflammatory responses are intensely implicated in airway damage.Besides, the massive release of cytokines, including interleuki…

Effect of high dose dexamethasone on platelets apoptosis in children with Chronic Immune Thrombocytopenic Purpura Open

Asmaa M. Zahran, Khalid I. Elsayh, Mona Soliman, Ismail Lotfy Mohamad · 2020

Approximately 10 to 20 percent of children who present with ITP develop chronic ITP, defined as platelet count <100,000/ micro L lasting beyond 12 months from the time of presentation. Recently, it was found that apoptosis may be one of th…

Sellf-Effiicacy of Adollescents wiith Thallassemiia Major Open

Eman Sadek, Khalid I. Elsayh, Fathia Mohammed, Nahed Mohamed, Sahar Faheem · 2020

Background: Adolescents suffering from chronic disease as thalassemia major are more susceptible for social, psychological, and physical barriers.Those barriers are generally more likely to be overcome if affected adolescents have a high l…

Upregulation of CD146 in Pediatric B‐Cell Acute Lymphocytic Leukemia and Its Implications on Treatment Outcomes Open

Asmaa M. Zahran, Omnia El‐Badawy, Khalid I. Elsayh, Wael M. Y. Mohamed, Khalid F. Riad , et al. · 2020

Background and Aim . We studied through flow cytometry the expression of CD146 on different T cells, and B‐cell ALL blasts trying to correlate its expression with different prognostic factors of B‐cell ALL and treatment outcomes. Patients …

Effect of Hydroxyurea Treatment on the Inflammatory Markers Among Children With Sickle Cell Disease Open

Asmaa M. Zahran, Asmaa Nafady, Khaled Saad, ‏Helal F. Hetta, Alameldin M. Abdallah , et al. · 2020

Background: Neutrophil-to-lymphocyte ratio (NLR) was introduced as a potential inflammatory marker in sickle cell disease (SCD). This study aimed to evaluate the impact of hydroxyurea (HU) treatment on the value of NLR and some inflammator…

Circulating Microparticles in Children With Sickle Cell Anemia in a Tertiary Center in Upper Egypt Open

Asmaa M. Zahran, Khalid I. Elsayh, Khaled Saad, Mostafa Embaby, Mervat A. M. Youssef , et al. · 2019

Sickle cell disease (SCD) is a genetically inherited hemolytic anemia increasingly appreciated as a chronic inflammatory condition and hypercoagulable state with high thrombotic risk. It is associated with disturbed immune phenotype and fu…

Down-regulation of Regulatory T-cells in Children With Gaucher Disease Under Enzyme Replacement Therapy Open

Asmaa M. Zahran, Khaled Saad, Mohamed Gamil M. Abo‐Elela, Esraa M. Eloseily, Eman F. Gad , et al. · 2019

Gaucher disease (GD) is one of the most important lysosomal storage disorders. T-lymphocytes perform and regulate many of the immune processes and play a major role in immune homeostasis. Studies have shown that GD causes impairment in T-l…

Circulating Endothelial Cells, Circulating Endothelial Progenitor Cells, and Circulating Microparticles in Type 1 Diabetes Mellitus Open

Asmaa M. Zahran, Ismail Mohamed, Osama M. El-Asheer, Deiaaeldin M. Tamer, Mohamed Gamil M. Abo‐Elela , et al. · 2019

Background and Aim: Hyperglycemia in type 1 diabetes (T1D) is accompanied by endothelial cell dysfunction which is known to contribute to the pathogenesis of cardiovascular disorders. The aim of the current study was to explore the profile…

Platelet Activation and Platelet–Leukocyte Aggregates in Type I Diabetes Mellitus Open

Asmaa M. Zahran, Omnia El‐Badawy, Ismail Lotfy Mohamad, Deiaaeldin M. Tamer, Safwat M. Abdel-Aziz , et al. · 2018

Hyperglycemia alone may not explain the increased risk of cardiovascular diseases (CVDs) in patients with type 1 diabetes (T1D) compared with type 2. This study emphases on the evaluation of some platelet activity markers in patients with …

Clinical Significance of T-Cell Immunoglobulin Mucin 3 Expression on Peripheral Blood Mononuclear Cells in Pediatric Acute Immune Thrombocytopenia Open

Asmaa M. Zahran, Mervat A. M. Youssef, Khalid I. Elsayh, Mostafa Embaby, Ahmad I. M. Ibrahim · 2017

T-cell immunoglobulin mucin 3 (TIM-3) is a transmembrane protein that plays an important role in several autoimmune diseases. The relationship between TIM-3 and excessive immune responses in immune thrombocytopenia (ITP) is still unknown. …

Regulatory and Memory B Lymphocytes in Children With Newly Diagnosed Immune Thrombocytopenia Open

Asmaa M. Zahran, Sanaa Shaker Aly, Ahmed El-Abd, Ismail Lotfy Mohamad, Khalid I. Elsayh · 2017

Analysis of Bregs and memory B cells could serve as prognostic markers and might guide therapy in ITP patients in the future.

Clinical and genetic assessment of pediatric patients with Gaucher’s disease in Upper Egypt Open

Tahia H. Saleem, Mohammed H. Hassan, Ahmed El‐Abd Ahmed, Ayat A. Sayed, Nahed Mohamed , et al. · 2016

Background: Gaucher’s disease (GD) is an autosomal recessive genetic disorder that results from pathogenic mutations of GBA gene encoding the enzyme glucocerebrosidase (acid β-glucosidase). Of the approximately 300 mutations associated wit…

Effect of Enzyme Replacement Therapy on Disease Burden Biomarkers in Gaucher's Disease Open

Mohammed H. Hassan, Ayat A. Sayed, Ahmed Ahmed, Tahia H. Saleem, Khalid I. Elsayh , et al. · 2016

Aims:We evaluate the effect of enzyme replacement therapy "ERT" on the plasma levels of some biochemical markers of the disease burden, in pediatric patients with Gaucher's disease "GD", in the form of plasma chitotriosidase "ChT", total a…

Effects of royal jelly supplementation on regulatory T cells in children with SLE Open

Asmaa M. Zahran, Khalid I. Elsayh, Khaled Saad, Esraa M. Eloseily, Naglaa S. Osman , et al. · 2016

This is the first human study on the effect of RJ supplementation in children with SLE. Our results showed improvements with 3-month RJ treatment with regard to the clinical severity score and laboratory markers for the disease. At this st…

Mothers' Knowledge and Practice about Conjunctivitis in Early Childhood at Assiut Ophthalmology Hospital Open

Huda Mohammed, Hekmat Abd-El-Krem, Khalid I. Elsayh · 2015

Conjunctivitis is an inflammation due to infection in the lining over the eyeball and inside the eyelids.Inflammation can cause blood vessels in the eye to become larger; this makes the white of the eye look pink or red.Conjunctivitis is c…

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