Khalid M. Kamal
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View article: Type of pre-existing chronic conditions and their associations with Merkel cell carcinoma (MCC) treatment: Prediction and interpretation using machine learning methods
Type of pre-existing chronic conditions and their associations with Merkel cell carcinoma (MCC) treatment: Prediction and interpretation using machine learning methods Open
Objective This study examined the prevalence of pre-existing chronic conditions and their association with the receipt of specific cancer-directed treatments among older adults with incident primary Merkel Cell Carcinoma (MCC) using novel …
View article: Prevalence of Tardive Dyskinesia and Its Association with Antipsychotic Drug and Depression in Geriatric Population in Lahore, Pakistan
Prevalence of Tardive Dyskinesia and Its Association with Antipsychotic Drug and Depression in Geriatric Population in Lahore, Pakistan Open
“Tardive Dyskinesia” is the subtle onset of rhythmic, stereotype, repetitive movement of the face, mouth, and tongue. The basic pathology behind this disease is hypersensitization of dopamine receptors. Objective: To find out the prevalenc…
View article: Effectiveness and Safety of Treatments for Early‐Stage Merkel Cell Carcinoma: A Systematic Review and Meta‐Analysis of Randomized and Non‐Randomized Studies
Effectiveness and Safety of Treatments for Early‐Stage Merkel Cell Carcinoma: A Systematic Review and Meta‐Analysis of Randomized and Non‐Randomized Studies Open
Objective The lack of consensus on the benefits and harms of standard therapies, including surgery (SRx), radiotherapy (RTx), chemotherapy (CTx), and their combinations among early‐stage MCC, prompted this study. Methods A systematic revie…
View article: Predictive and Interpretable Machine Learning of Economic Burden: The Role of Chronic Conditions Among Elderly Patients with Incident Primary Merkel Cell Carcinoma (MCC)
Predictive and Interpretable Machine Learning of Economic Burden: The Role of Chronic Conditions Among Elderly Patients with Incident Primary Merkel Cell Carcinoma (MCC) Open
Among older adults with MCC, cardiac and renal conditions were the leading drivers of total expenditures and OOP expenditures. Our findings suggest that managing cardiac and renal conditions may be important for cost containment efforts.
View article: Development of a local nomogram‐based scoring system for predicting overall survival in idiopathic pulmonary fibrosis: A rural appalachian experience
Development of a local nomogram‐based scoring system for predicting overall survival in idiopathic pulmonary fibrosis: A rural appalachian experience Open
Background Accurate staging systems are essential for assessing the severity of idiopathic pulmonary fibrosis (IPF) and guiding clinical management. This study aimed to evaluate the prognostic value of pulmonary comorbidities and body mass…
View article: Real-World Effectiveness, Economic, and Humanistic Outcomes of Selected Oral Antipsychotics in Patients with Schizophrenia: A Systematic Review Evaluating Global Evidence
Real-World Effectiveness, Economic, and Humanistic Outcomes of Selected Oral Antipsychotics in Patients with Schizophrenia: A Systematic Review Evaluating Global Evidence Open
Our research showcased a significant knowledge gap across OATs spanning the humanistic and behavioral outcomes and medication adherence and switching, suggesting a need for robust evidence generation to help clinicians and payers make info…
View article: Evaluating the St. George’s respiratory questionnaire in idiopathic pulmonary fibrosis: a systematic review with meta-analysis of psychometric properties using COSMIN
Evaluating the St. George’s respiratory questionnaire in idiopathic pulmonary fibrosis: a systematic review with meta-analysis of psychometric properties using COSMIN Open
Background The St. George’s Respiratory Questionnaire (SGRQ) and its idiopathic pulmonary fibrosis (IPF) version (SGRQ-I) are widely used to assess health-related quality of life in IPF. However, the psychometric properties of these questi…
View article: A systematic review of the real-world effectiveness and economic and humanistic outcomes of selected oral antipsychotics among patients with schizophrenia in the United States: Updating the evidence and gaps
A systematic review of the real-world effectiveness and economic and humanistic outcomes of selected oral antipsychotics among patients with schizophrenia in the United States: Updating the evidence and gaps Open
Our findings showed considerable gaps exist for evidence on behavioral outcomes, humanistic outcomes, medication switching, and adherence/persistence across OATs. Our findings also suggest an unmet need regarding treatment nonadherence and…
View article: Part II: After you accept that faculty position …
Part II: After you accept that faculty position … Open
The objective of Part II of this CNSNT editorial series is to help you hit the ground running upon arrival at your new position. As far as possible, you will want to sail across the hurdles in your way, not barely clear them and risk failu…
View article: Part I: Before you apply for that faculty position …
Part I: Before you apply for that faculty position … Open
The objective of this two-part CNSNT editorial is to provide real-world, frank advice for scientists joining an academic or research institution. Based on our experience on hiring committees and mentorship of the next generation of scienti…
View article: Evaluation of a pharmacist-provider collaborative clinic for treatment of iron deficiency in patients with heart failure
Evaluation of a pharmacist-provider collaborative clinic for treatment of iron deficiency in patients with heart failure Open
Purpose Intravenous iron therapy is recommended to improve symptoms and exercise tolerance in patients with heart failure (HF) with reduced ejection fraction and iron deficiency (ID), but there are limited published data on the implementa…
View article: Review of: "Effectiveness of a novel multi-modal intervention for family caregivers of persons with age-related macular degeneration: a randomised controlled trial"
Review of: "Effectiveness of a novel multi-modal intervention for family caregivers of persons with age-related macular degeneration: a randomised controlled trial" Open
Potential competing interests: No potential competing interests to declare.Overall, the study is well done.
View article: The role of managed care professionals in the management of neovascular age-related macular degeneration and diabetic macular edema
The role of managed care professionals in the management of neovascular age-related macular degeneration and diabetic macular edema Open
Managed care professionals play a significant role in the management of neovascular age-related macular degeneration (nAMD) and diabetic macular edema (DME) through formulary management and drug utilization strategies. These strategies are…
View article: Burnout and Depressive Symptoms in Healthcare Professionals: A Cross-Sectional Study in Saudi Arabia
Burnout and Depressive Symptoms in Healthcare Professionals: A Cross-Sectional Study in Saudi Arabia Open
Objectives. The study objectives were to examine the prevalence of burnout among healthcare professionals, analyze the association of depression and burnout among healthcare professionals, and explore the factors related to burnout. Method…
View article: Cost impact of different treatment regimens of brolucizumab in neovascular age-related macular degeneration: A budget impact analysis
Cost impact of different treatment regimens of brolucizumab in neovascular age-related macular degeneration: A budget impact analysis Open
BACKGROUND: Brolucizumab is a new anti-vascular endothelial growth factor (anti-VEGF) approved for treating neovascular age-related macular degeneration (nAMD). Multiple treatment regimens are available for treating nAMD. These regimens in…
View article: Disposal practices for unused and expired medications: pilot data from three cities in three countries
Disposal practices for unused and expired medications: pilot data from three cities in three countries Open
Objective: To collect pilot data on medication disposal practices of unused and expired medications from three cities in three countries. Methods: A cross-sectional survey was conducted in Pittsburgh, United States (US); Turin, Italy; and …
View article: Adherence to cystic fibrosis transmembrane conductance regulator (CFTR) modulators: analysis of a national specialty pharmacy database
Adherence to cystic fibrosis transmembrane conductance regulator (CFTR) modulators: analysis of a national specialty pharmacy database Open
To the best of our knowledge, this is the first study to assess the adherence of three CFTR modulators using a large nationwide specialty database. With high acquisition costs of CFTR modulator therapies, there is a need to improve rates o…
View article: Retinal Dystrophy, Obesity and Hypertension in an Adolescent Boy
Retinal Dystrophy, Obesity and Hypertension in an Adolescent Boy Open
Bardet-Biedl syndrome (BBS) is a pleiotropic genetic disorder characterized by congenital and late onset defects. It is associated with retinal dystrophy, obesity, polydactyly, hypogonadism and renal dysfunction. Proper management and regu…
View article: The Relationship between Knowledge, Attitudes, and Practices of Community Pharmacists Regarding Persons with Substance use Disorders
The Relationship between Knowledge, Attitudes, and Practices of Community Pharmacists Regarding Persons with Substance use Disorders Open
Background Community pharmacists can play a meaningful role in identification and treatment of substance use disorders (SUD). However, inadequate disease knowledge and negative attitudes are known barriers. The relationship between knowled…
View article: Description of Pharmacists’ Reported Interventions to Prevent Prescribing Errors among in Hospital Inpatients: A Cross Sectional Retrospective Study
Description of Pharmacists’ Reported Interventions to Prevent Prescribing Errors among in Hospital Inpatients: A Cross Sectional Retrospective Study Open
Background: Prescribing errors (PEs) are a common cause of morbidity and mortality, both in community practice and in hospitals. Pharmacists have an essential role in minimizing and preventing PEs, thus, there is a need to document the nat…