Khalid Rauf
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An assessment of various disinfectants using the Kirby-Bauer Method with disc diffusion to determine their effectiveness against locally isolated pathogens Open
This study aimed to assess the effectiveness of various disinfectants against locally isolated pathogens using the Kirby-Bauer Method with disc diffusion. Indigenous strains of Salmonella typhimurium, E. coli, Campylobacter, Citrobacter fr…
6-Methoxyflavone improves anxiety, depression, and memory by increasing monoamines in mice brain: HPLC analysis and <i>in silico</i> studies Open
6-Methoxyflavone (6-MOF) is a flavonoid that has been reported to be a GABA-A receptor agonist and reverses cisplatin-induced hyperalgesia and allodynia. Considering the varied neuropharmacological profile of 6-MOF, this study was intended…
5,7-Dimethoxycoumarin ameliorates vincristine induced neuropathic pain: potential role of 5HT3 receptors and monoamines Open
Vincristine is the drug of choice for Hodgkin’s lymphoma, acute lymphoblastic leukemia, and non-Hodgkin lymphoma. Despite its significant anticancer effects, it causes dose-dependent neuropathy, leading to compulsive dose reduction. The av…
Diosgenin normalization of disrupted behavioral and central neurochemical activity after single prolonged stress Open
Introduction: Post-traumatic stress disorder (PTSD) is a chronic mental illness triggered by traumatic experiences such as wars, natural disasters, or catastrophes, and it is characterized by anxiety, depression and cognitive impairment. D…
Effect of Gabapentin-Fluoxetine Derivative GBP1F in a Murine Model of Depression, Anxiety and Cognition Open
GBP1F induced a mild suppression of locomotor activity, ameliorated anxiety and depression-like behavior, did not alter cognitive behavior, and raised serotonin and 5-HIAA concentrations in the hippocampus and striatum. GBP1F also positive…
Fraxetin attenuates disrupted behavioral and central neurochemical activity in a model of chronic unpredictable stress Open
Purpose: Chronic unpredictable stress (CUS) induces long-term neuronal and synaptic plasticity with a neurohormonal disbalance leading to the development of co-existing anxiety, depression, and cognitive decline. The side effects and delay…
Effects of 1-methyl-1, 2, 3, 4-tetrahydroisoquinoline on a diabetic neuropathic pain model Open
Background: Neuropathy is a prevalent and debilitating complication of poorly managed diabetes, contributing towards poor quality of life, amputation risk, and increased mortality. The available therapies for diabetic neuropathic pain (DPN…
6-Methoxyflavone and Donepezil Behavioral Plus Neurochemical Correlates in Reversing Chronic Ethanol and Withdrawal Induced Cognitive Impairment Open
It is postulated that, apart from donepezil, 6-MOF may be useful not only in the treatment of ethanol withdrawal severity but also in the management of chronic ethanol withdrawal induced cognitive impairment.
View article: Ethylacetate fraction of Anthocleista vogelii Planch demonstrates antiobesity activities in preclinical models
Ethylacetate fraction of Anthocleista vogelii Planch demonstrates antiobesity activities in preclinical models Open
Purpose: To assess the anti-obesity effect of liquid chromatography mass spectrometry (LCMS) profiled ethylacetate fraction (EF) of Anthocleista vogelii Planch on pancreatic lipase activity in vitro, and on obesity-related hormones in high…
View article: Chemical composition and in vitro antiobesity and in vivo anti-hyperlipidemic effects of Ceratotheca sesamoides, Jatropha tanjorensis, Mucuna flagellipes, Pterocarpus mildbraedii and Piper guineense
Chemical composition and in vitro antiobesity and in vivo anti-hyperlipidemic effects of Ceratotheca sesamoides, Jatropha tanjorensis, Mucuna flagellipes, Pterocarpus mildbraedii and Piper guineense Open
Ethnopharmacological relevance: Ceratotheca sesamoides, Jatropha tanjorensis, Mucuna flagellipes, Pterocarpus mildbraedii and Piper guineense are all medicinal plants found in West Africa and used traditionally for the treatment of various…
In Vitro Antioxidant, Anti-inflammatory, and In Vivo Anticolitis Effects of Combretin A and Combretin B on Dextran Sodium Sulfate-Induced Ulcerative Colitis in Mice Open
Combretum fragrans (Combretaceae) is a Cameroonian medicinal plant containing various secondary metabolites and traditionally used for the treatment of several pathologies. Two cycloartane-type triterpenes, Combretin A and Combretin B, wer…
Potential Role of Proton Pump Inhibitors Against Human DRD2 Receptor in Drug Induced Hyperprolactinemia Open
Dopamine is a catecholamine neurotransmitter that control several important functions via different dopamine receptors(D1-D5). The Dopamine (DRD2) receptor and other D2 family receptors (D3 and D4) are predominantly involved in the inhibit…
Analgesic and Antiallodynic Effects of 4-Fluoro-N-(4-Sulfamoylbenzyl) Benzene Sulfonamide in a Murine Model of Pain Open
Naeem Ur Rehman,1 Mariya al-Rashida,2 Ahmed Tokhi,1 Zainab Ahmed,1 Fazal Subhan,1 Muzaffar Abbas,3 Muhammad Awais Arshid,4 Khalid Rauf1 1Department of Pharmacy, COMSATS University Islamabad, Abbottabad Campus, Abbottabad, Pakistan; 2Depart…
Kaempferol Facilitated Extinction Learning in Contextual Fear Conditioned Rats via Inhibition of Fatty-Acid Amide Hydrolase Open
Background: Fear, stress, and anxiety-like behaviors originate from traumatic events in life. Stress response is managed by endocannabinoids in the body by limiting the uncontrolled retrieval of aversive memories. Pharmacotherapy-modulatin…
Analgesic and Antiallodynic Effects of 4-Fluoro-N-(4-Sulfamoylbenzyl) Benzene Sulfonamide in a Murine Model of Pain Open
These findings are significant and promising while further studies are warranted to explore the exact molecular mechanism and the potential of 4-FBS in diabetic neuropathic pain.
Effect of 4-Fluoro-N-(4-sulfamoylbenzyl) Benzene Sulfonamide on cognitive deficits and hippocampal plasticity during nicotine withdrawal in rats Open
Withdrawal from chronic nicotine has damaging effects on a variety of learning and memory tasks. Various Sulfonamides that act as carbonic anhydrase inhibitors have documented role in modulation of various cognitive, learning, and memory p…
Effect of 4-fluoro-N-(4-sulfamoylbenzyl) benzene sulfonamide on acquisition and expression of nicotine-induced behavioral sensitization and striatal adenosine levels Open
Introduction: Behavioral sensitization is a phenomenon that develops from intermittent exposure to nicotine and other psychostimulants, which often leads to heightened locomotor activity and then relapse. Sulfonamides that act as carbonic …
Effect of 4-Fluoro-N-(4-Sulfamoylbenzyl) Benzene Sulfonamide on Acquisition and Expression of Nicotine-Induced Behavioral Sensitization and Striatal Adenosine Levels Open
The behavioral and adenosine modulation is promising, and more receptors level studies are warranted to explore the exact mechanism of action of 4-FBS.
A Novel Sulfonamide, 4-FS, Reduces Ethanol Drinking and Physical Withdrawal Associated With Ethanol Dependence Open
Carbonic anhydrase (CA) is abundant in glial cells in the brain and CA type II isoform (CA II) activity in the hippocampus plays an important role in buffering extracellular pH transients produced by neural activity. Chronic ethanol exposu…
Antipsychotic effects of philenoptera cyanescens (schum. & thonn.) roberty (leguminosae) leaf extract and fractions against ketamine-induced psychosis in mice Open
This study investigated the antipsychotic potentials of Philenoptera cyanescens (PC) methanol extract and fractions against ketamine-induced psychosis in Balb/C mice.The methods used were the hyper-locomotion, stereotype behaviour, Y-maze …
View article: Synthesis, characterization and docking studies of amide ligands as anti-leishmanial agents.
Synthesis, characterization and docking studies of amide ligands as anti-leishmanial agents. Open
Aim of this study was to synthesize new inhibitors on the basis of active site of aspartic protease enzyme and to evaluate their intended biological activity. A3D model of an enzyme was generated via homology modeling and series of novel a…
Effect of commercial and green synthesized ZnO NPs in murine model of chloroquine-induced pruritus Open
Nargis Aman, Khalid Rauf, Shujaat Ali Khan, Ahmed Tokhi, Naeem-Ur Rehman, Muhammad Arfat YameenDepartment of Pharmacy COMSATS University Islamabad, Abbottabad Campus, Abbottabad, KPK, PakistanPurpose: To investigate the effects of zinc oxi…
Effect of commercial and green synthesized ZnO NPs in murine model of chloroquine-induced pruritus Open
Purpose: To investigate the effects of zinc oxide nanoparticles (ZnO NPs) on chloroquine (CQ)-induced itching, and overall behavior of mice after oral administration of ZnO NPs of various sizes and doses. Background: With the wide-spread u…
The Impact of Plasmodium Berghei Exposure In-utero on Neurobehavioral Profile in Mice Open
It may be concluded that In-utero exposure to experimental malaria in mice causes behavioral changes.
View article: In vitro Antiobesity Activities and In vivo Anti-Lipolytic Effect of Alstonia boonei Stem Bark Fraction
In vitro Antiobesity Activities and In vivo Anti-Lipolytic Effect of Alstonia boonei Stem Bark Fraction Open
The aim of this study was to investigate the in vitro antiobesity activities and in vivo anti-lipolytic effect of Terpenoids and Lipid derivatives fraction (TLDF) of Alstonia boonei stem bark.
View article: DIURETIC, ANTIDIURETIC AND LAXATIVE ACTIVITIES OF ANTHOCLEISTA VOGELII EXTRACTS IN RATS
DIURETIC, ANTIDIURETIC AND LAXATIVE ACTIVITIES OF ANTHOCLEISTA VOGELII EXTRACTS IN RATS Open
Background: Anthocleista vogelii Planch is a medicinal plant used by traditional healers in the treatment of Malaria, hypertension, ulcer, obesity, diabetes, and as a diuretic and purgative in Africa.Therefore, the present study sought to …
DIURETIC, ANTIDIURETIC AND LAXATIVE ACTIVITIES OF ANTHOCLEISTA VOGELII EXTRACTS IN RATS Open
Background: Anthocleista vogelii Planch is a medicinal plant used by traditional healers in the treatment of Malaria, hypertension, ulcer, obesity, diabetes, and as a diuretic and purgative in Africa. Therefore, the present study sought to…