Ali R. Khan
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View article: A Theory of Localized Iron Accumulation Facilitating Chronic and Concurrent Neurodegeneration
A Theory of Localized Iron Accumulation Facilitating Chronic and Concurrent Neurodegeneration Open
Iron is essential in all cells, but paradoxically accumulates in various regions across neurodegenerative diseases including Multiple Sclerosis, Alzheimer’s disease, traumatic brain injuries, frontotemporal dementia, Amyotrophic Lateral Sc…
View article: Hippocampal grey matter changes across scales in Alzheimer’s Disease
Hippocampal grey matter changes across scales in Alzheimer’s Disease Open
Alzheimer’s disease (AD) is a progressive and debilitating neurodegenerative disease of the central nervous system, characterized by deterioration in cognitive function including extensive memory impairment. The hippocampus, a medial tempo…
View article: HippoMaps: multiscale cartography of human hippocampal organization
HippoMaps: multiscale cartography of human hippocampal organization Open
View article: Trichoderma-mediated iron oxide nanoproduct improves drought tolerance and carbon sequestration in industrial woody plants
Trichoderma-mediated iron oxide nanoproduct improves drought tolerance and carbon sequestration in industrial woody plants Open
View article: Attentional modulation of stimulus-synchronized BOLD oscillations in the human visual cortex
Attentional modulation of stimulus-synchronized BOLD oscillations in the human visual cortex Open
View article: Multiplexed BOLD oscillations reveal the interplay of normalization and attention
Multiplexed BOLD oscillations reveal the interplay of normalization and attention Open
Monkey electrophysiology has linked attention to divisive normalization, yet noninvasive evidence in humans remains limited. We use frequency-tagged fMRI to isolate visual cortical populations that simultaneously encode multiple competing …
View article: Neurite Density and Kurtosis in the Gray Matter of People With Early Schizophrenia
Neurite Density and Kurtosis in the Gray Matter of People With Early Schizophrenia Open
Increases in mean kurtosis and isotropic diffusion fraction are both markers of schizophrenia, consistent with inflammation models of the gray matter in schizophrenia. NDI reduction, reflecting intraneurite pathology, becomes prominent onl…
View article: Early life stress impairs hippocampal subfield myelination
Early life stress impairs hippocampal subfield myelination Open
The hippocampus is an archicortical structure that is highly sensitive to experience and is made up of individual subfields. These subfields, crucial for learning and memory, rapidly develop and are vulnerable to early stress, yet the mech…
View article: Knowledge, Attitudes, and Practices Regarding Monkeypox Among Healthcare Professionals in Lahore
Knowledge, Attitudes, and Practices Regarding Monkeypox Among Healthcare Professionals in Lahore Open
Background: Monkeypox (Mpox), a re-emerging zoonotic disease, poses a growing threat to global health, especially in non-endemic regions. Healthcare professionals (HCPs) serve as the first line of defense against such outbreaks. However, l…
View article: Midbrain and pallidal iron changes identify patients with REM sleep behaviour disorder and Parkinson’s disease
Midbrain and pallidal iron changes identify patients with REM sleep behaviour disorder and Parkinson’s disease Open
Idiopathic REM sleep behaviour disorder (iRBD) is considered a prodromal form of Parkinson's Disease (PD), potentially exhibiting similar patterns of neurodegeneration, such as brain iron changes. We investigated midbrain and pallidal iron…
View article: Brassinosteroids Alleviate Ethylene-Induced Copper Oxide Nanoparticle Toxicity and Ultrastructural and Stomatal Damage in Rice Seedlings
Brassinosteroids Alleviate Ethylene-Induced Copper Oxide Nanoparticle Toxicity and Ultrastructural and Stomatal Damage in Rice Seedlings Open
Nanoparticle contamination has been associated with adverse impacts on crop productivity. Thus, effective approaches are necessary to ameliorate NP-induced phytotoxicity. The present study aimed to investigate the efficacy of brassinostero…
View article: Convergence of Cannabis and Psychosis on the Dopamine System
Convergence of Cannabis and Psychosis on the Dopamine System Open
Importance Despite evidence that individuals with a cannabis use disorder (CUD) are at elevated risk of psychosis and that the neurotransmitter dopamine has a role in psychosis, the mechanism linking cannabis use and psychosis remains uncl…
View article: Impact of Sensory-adapted Dental Environment on Potentially Cooperative Children: An Observational Study
Impact of Sensory-adapted Dental Environment on Potentially Cooperative Children: An Observational Study Open
Aim: The present study is an observational study assessing the impact of a sensory-adapted dental environment (SADE) over a routine dental environment (RDE) on potentially cooperative children receiving routine oral healthcare. Materials a…
View article: Efficacy of High-Dose Statins in Preventing Contrast-Induced Nephropathy Post-cardiac Catheterization
Efficacy of High-Dose Statins in Preventing Contrast-Induced Nephropathy Post-cardiac Catheterization Open
View article: Gauge equivariant convolutional neural networks for diffusion MRI
Gauge equivariant convolutional neural networks for diffusion MRI Open
View article: Stable White Matter Structure in the First Three Years After Psychosis Onset
Stable White Matter Structure in the First Three Years After Psychosis Onset Open
White matter does not appear to be susceptible to schizophrenia-linked degeneration in the early stages of disease, but preexisting pathology may be linked to disease severity.
View article: Mapping the topographic organization of the human zona incerta using diffusion MRI
Mapping the topographic organization of the human zona incerta using diffusion MRI Open
The zona incerta (ZI) is a deep brain region originally described by Auguste Forel as an “immensely confusing area about which nothing can be said.” Despite the elusive nature of this structure, mounting evidence supports the role of the Z…
View article: Mapping the topographic organization of the human zona incerta using diffusion MRI
Mapping the topographic organization of the human zona incerta using diffusion MRI Open
The zona incerta (ZI) is a deep brain region originally described by Auguste Forel as an “immensely confusing area about which nothing can be said.” Despite the elusive nature of this structure, mounting evidence supports the role of the Z…
View article: Older adults at‐risk for type 2 diabetes exhibit decreased performance on spatial and working memory tasks using classic and novel cognitive testing
Older adults at‐risk for type 2 diabetes exhibit decreased performance on spatial and working memory tasks using classic and novel cognitive testing Open
Background Type 2 diabetes (T2D) and older age are well‐known risk factors for dementia. Indeed, there is evidence that older adults not diagnosed, but at‐risk for T2D can show early signs of cognitive decline, further exacerbated by exces…
View article: Lower brain‐derived neurotrophic factor levels and hippocampal subfield volumes are associated with high diabetes risk in later life
Lower brain‐derived neurotrophic factor levels and hippocampal subfield volumes are associated with high diabetes risk in later life Open
Background Older adults with type 2 diabetes (T2D) are more likely to develop Alzheimer’s disease (AD) due to impaired brain metabolism. Although the underlying mechanisms of this relationship are largely unknown, lower levels of brain‐der…
View article: Older adults at‐risk for type 2 diabetes exhibit decreased performance on spatial and working memory tasks using classic and novel cognitive testing
Older adults at‐risk for type 2 diabetes exhibit decreased performance on spatial and working memory tasks using classic and novel cognitive testing Open
Background Type 2 diabetes (T2D) and older age are well‐known risk factors for dementia. Indeed, there is evidence that older adults not diagnosed, but at‐risk for T2D can show early signs of cognitive decline, further exacerbated by exces…
View article: A Taguchi Approach for Optimization of Antimicrobial Effect of Whey Protein Based Edible Film Fermented by Bacillus clausii
A Taguchi Approach for Optimization of Antimicrobial Effect of Whey Protein Based Edible Film Fermented by Bacillus clausii Open
Bacillus clausii, an antagonistic bacterium, was utilized to develop antimicrobial edible films based on whey protein concentrate. This study employed a Taguchi test (3 × 3) to evaluate the impact of temperature, pH, and protein concentrat…
View article: Double Trouble in the Basement! A Case of PLA2R-Associated Membranous Nephropathy with Atypical Anti-Glomerular Basement Membrane Disease
Double Trouble in the Basement! A Case of PLA2R-Associated Membranous Nephropathy with Atypical Anti-Glomerular Basement Membrane Disease Open
Introduction: Concurrent atypical anti-glomerular basement membrane (anti-GBM) disease with membranous nephropathy is a rare occurrence. Compared to typical anti-GBM disease, atypical anti-GBM disease is often seronegative, with a mild dis…
View article: Automated and Interpretable Detection of Hippocampal Sclerosis in Temporal Lobe Epilepsy: <scp>AID</scp> ‐ <scp>HS</scp>
Automated and Interpretable Detection of Hippocampal Sclerosis in Temporal Lobe Epilepsy: <span>AID</span> ‐ <span>HS</span> Open
Objective Hippocampal sclerosis (HS), the most common pathology associated with temporal lobe epilepsy (TLE), is not always visible on magnetic resonance imaging (MRI), causing surgical delays and reduced postsurgical seizure‐freedom. We d…
View article: Multimodal gradients of basal forebrain connectivity across the neocortex
Multimodal gradients of basal forebrain connectivity across the neocortex Open
Cortical cholinergic projections originate from subregions of the basal forebrain (BF). To examine its organization in humans, we computed multimodal gradients of BF connectivity by combining 7 T diffusion and resting state functional MRI.…
View article: Mapping the topographic organization of the human zona incerta using diffusion MRI
Mapping the topographic organization of the human zona incerta using diffusion MRI Open
The zona incerta (ZI) is a deep brain region originally described by Auguste Forel as an “immensely confusing area about which nothing can be said.” Despite the elusive nature of this structure, mounting evidence supports the role of the Z…
View article: Stable White Matter Structure in the First Three Years after Psychosis Onset
Stable White Matter Structure in the First Three Years after Psychosis Onset Open
Background White matter alterations observed using diffusion weighted imaging have become a hallmark of chronic schizophrenia, but it is unclear when these changes arise over the course of the disease. Nearly all studies thus far have been…
View article: The developing hippocampus: Microstructural evolution through childhood and adolescence
The developing hippocampus: Microstructural evolution through childhood and adolescence Open
The hippocampus is a structure in the medial temporal lobe which serves multiple cognitive functions. While important, the development of the hippocampus in the formative period of childhood and adolescence has not been extensively investi…
View article: Increased mean diffusivity of the caudal motor SNc identifies patients with REM sleep behaviour disorder and Parkinson’s disease
Increased mean diffusivity of the caudal motor SNc identifies patients with REM sleep behaviour disorder and Parkinson’s disease Open
Idiopathic rapid eye movement sleep behaviour disorder (iRBD)—a Parkinson’s disease (PD) prodrome—might exhibit neural changes similar to those in PD. Substantia nigra pars compacta (SNc) degeneration underlies motor symptoms of PD. In iRB…
View article: Diffusion MRI of the Hippocampus
Diffusion MRI of the Hippocampus Open
The hippocampus is a brain structure that plays key roles in a variety of cognitive processes. Critically, a wide range of neurological disorders are associated with degeneration of the hippocampal microstructure, defined as neurons, dendr…