Luan‐Yin Chang
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View article: Age redistribution and altered RSV seasonality in Taiwan: A multicenter analysis from 2015 to 2023
Age redistribution and altered RSV seasonality in Taiwan: A multicenter analysis from 2015 to 2023 Open
The shift in age distribution and increased bacterial codetections highlight the need for ongoing RSV surveillance. Given the unpredictability of RSV seasonality, both maternal immunization and monoclonal antibody administration may offer …
View article: Post-COVID-19 resurgence of respiratory viruses in Taiwan: an interrupted time series analysis from three regional medical centers (2015–2023)
Post-COVID-19 resurgence of respiratory viruses in Taiwan: an interrupted time series analysis from three regional medical centers (2015–2023) Open
View article: The Association of RNase L, Cytokines, and Chemokines With Severity of Multisystem Inflammatory Syndrome in Children
The Association of RNase L, Cytokines, and Chemokines With Severity of Multisystem Inflammatory Syndrome in Children Open
The 2′,5′‐oligoadenylate synthetase (OAS)‐ribonuclease L (RNase L) system, induced by type I interferons, defends against RNA viruses. Inborn errors in this pathway may trigger inflammatory cytokines, contributing to SARS‐CoV‐2‐related mul…
View article: The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases
The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases Open
The epithelial barrier theory proposes that modern environmental exposures compromise skin and mucosal surfaces, initiating local inflammation that propagates systemically. The theory integrates epidemiological trends, molecular mechanisti…
View article: The impact of COVID-19 on psychophysiology and quality of life among children during omicron surge in Taiwan
The impact of COVID-19 on psychophysiology and quality of life among children during omicron surge in Taiwan Open
The long COVID group had more severe physical and psychological symptoms, family dysfunction, and school-related stress, indicating a need for further assistance.
View article: Comparison of Clinical Features and Severity of Subgroup A and B Respiratory Syncytial Virus Infection
Comparison of Clinical Features and Severity of Subgroup A and B Respiratory Syncytial Virus Infection Open
Respiratory syncytial virus (RSV) is a leading cause of acute lower respiratory tract disease. This study investigated the clinical differences between RSV subgroups A and B using data from a university‐affiliated medical center in Taiwan …
View article: Age-stratified seroprevalence of enterovirus D68 and the need for cohort studies in children
Age-stratified seroprevalence of enterovirus D68 and the need for cohort studies in children Open
View article: Kiến thức, thực hành đối với chiến lược rửa tay và đeo khẩu trang trong đại dịch covid-19 của các bệnh nhân đến khám ngoại trú tại Bệnh viện Thống Nhất: khảo sát cắt ngang
Kiến thức, thực hành đối với chiến lược rửa tay và đeo khẩu trang trong đại dịch covid-19 của các bệnh nhân đến khám ngoại trú tại Bệnh viện Thống Nhất: khảo sát cắt ngang Open
Đặt vấn đề: Đối mặt với đại dịch COVID-19 (coronavirus disease 2019), Việt Nam đã áp dụng nhiều chiến lược khác nhau để phòng và kiểm soát lây nhiễm trong cộng đồng. Hiệu quả của các chiến lược này phụ thuộc vào sự hợp tác và tuân thủ của …
View article: Acceleration Response Reconstruction for Structural Health Monitoring Based on Fully Convolutional Networks
Acceleration Response Reconstruction for Structural Health Monitoring Based on Fully Convolutional Networks Open
View article: Preoperative 3D printing planning technology combined with orthopedic surgical robot-assisted minimally invasive screw fixation for the treatment of pelvic fractures: a retrospective study
Preoperative 3D printing planning technology combined with orthopedic surgical robot-assisted minimally invasive screw fixation for the treatment of pelvic fractures: a retrospective study Open
Objective To explore the advantages and effectiveness of preoperative 3D printing planning technology combined with orthopedic surgical robot-assisted screw placement in the minimally invasive treatment of pelvic fractures compared to orth…
View article: Critical COVID-19 in children and adolescents during the 2022 Omicron Surge in Taiwan: Risk factors and vaccine effectiveness
Critical COVID-19 in children and adolescents during the 2022 Omicron Surge in Taiwan: Risk factors and vaccine effectiveness Open
View article: Signatures of lower respiratory tract microbiome in children with severe community-acquired pneumonia using shotgun metagenomic sequencing
Signatures of lower respiratory tract microbiome in children with severe community-acquired pneumonia using shotgun metagenomic sequencing Open
This study demonstrated that significantly different microbial community was associated with severity of community-acquired pneumonia requiring intensive care admission. Species-level shotgun metagenomic sequencing facilitates the explorat…
View article: Increased post-COVID-19 behavioral, emotional, and social problems in Taiwanese children
Increased post-COVID-19 behavioral, emotional, and social problems in Taiwanese children Open
The present study identified a significant link between SARS-CoV-2 infection and various post-COVID mental health sequelae in children, including behavioral/emotional and social adjustment challenges. Our results underline the importance o…
View article: Febrile young infants and the association with enterovirus infection
Febrile young infants and the association with enterovirus infection Open
Enterovirus accounted for 17.4% of the etiology in febrile young infants and the case-fatality rate was 2%. Febrile young infants who had risk factors of enterovirus infection should consider viral culture or PCR examination for confirmati…
View article: Clinical characteristics and outcomes of children with COVID-19 in pediatric intensive care units during the Omicron wave in Taiwan
Clinical characteristics and outcomes of children with COVID-19 in pediatric intensive care units during the Omicron wave in Taiwan Open
Without available vaccinations and suitable treatment guidelines, children with COVID-19 tended to have more severe illness and prolonged LOS in the PICU. These observations highlight the importance of vaccinations and familiarity of medic…
View article: Multicenter registry of multisystem inflammatory syndrome in children (MIS-C) and Paired comparison with Kawasaki disease
Multicenter registry of multisystem inflammatory syndrome in children (MIS-C) and Paired comparison with Kawasaki disease Open
We identified two independent risk factors associated with hemodynamic compromise in MIS-C patients. The comparison between matched MIS-C and KD patients highlighted significant differences in clinical presentations, like BCG red halos, wh…
View article: Secular trend of Kawasaki disease and its correlation with viral activity in Taiwan: a nationwide population-based study
Secular trend of Kawasaki disease and its correlation with viral activity in Taiwan: a nationwide population-based study Open
View article: Seroprevalence of SARS-CoV-2 in self-reported COVID-19-free children
Seroprevalence of SARS-CoV-2 in self-reported COVID-19-free children Open
We discovered previously undisclosed cases of SARS-CoV-2 infection among children. The risk of seropositivity increases substantially with household contact. Regarding children who report no prior exposure to COVID-19, clinicians must rema…
View article: Clinical characteristics and risk factors of severe human parainfluenza virus infection in hospitalized children
Clinical characteristics and risk factors of severe human parainfluenza virus infection in hospitalized children Open
Background: Human parainfluenza viruses (HPIVs) commonly cause childhood respiratory illness requiring hospitalization in Taiwan. This study aimed to investigate clinical severity and identify risk factors predisposing to severe disease in…
View article: [Multicenter retrospect analysis of early clinical features and analysis of risk factors on prognosis of elderly patients with severe burns].
[Multicenter retrospect analysis of early clinical features and analysis of risk factors on prognosis of elderly patients with severe burns]. Open
Objective: To investigate the early clinical characteristics of elderly patients with severe burns and the risk factors on prognosis. Methods: This study was a retrospective case series study. Clinical data of 124 elderly pat…
View article: High incidence of cerebrovascular lesions on magnetic resonance imaging in pediatric COVID-19 during omicron outbreak – A retrospective case series
High incidence of cerebrovascular lesions on magnetic resonance imaging in pediatric COVID-19 during omicron outbreak – A retrospective case series Open
A high proportion of vascular abnormalities was observed in pediatric patients with neurological involvements, suggesting that vascular involvement is an important mechanism of neurological manifestations in omicron variant infection.
View article: Clinical manifestations and risk factors of shock in children with multisystem inflammatory syndrome
Clinical manifestations and risk factors of shock in children with multisystem inflammatory syndrome Open
MIS-C patients with high initial procalcitonin levels have higher risks of experiencing shock and may need ICU admission.
View article: Outcomes of pediatric community‐acquired pneumonia before and after national pneumococcal immunization in Taiwan
Outcomes of pediatric community‐acquired pneumonia before and after national pneumococcal immunization in Taiwan Open
Objective In Taiwan, the incidence of invasive pneumococcal disease (IPD) in children declined after the catch‐up primary vaccination programs and the full national immunization program (NIP) with PCV13. The objective of the study was to i…
View article: Clinical characteristics and factors associated with severe COVID-19 in hospitalized children during the SARS-CoV-2 Omicron pandemic in Taiwan
Clinical characteristics and factors associated with severe COVID-19 in hospitalized children during the SARS-CoV-2 Omicron pandemic in Taiwan Open
Vital signs need close monitoring, early management and/or intensive care may be applied in COVID-19 patients with congenital cardiovascular diseases, fever lasting ≥4 days, seizures, desaturation and/or elevated procalcition since they ar…
View article: Serostatus of echovirus 11, coxsackievirus B3 and enterovirus D68 in cord blood: The implication of severe newborn enterovirus infection
Serostatus of echovirus 11, coxsackievirus B3 and enterovirus D68 in cord blood: The implication of severe newborn enterovirus infection Open
Cord blood seropositive rate and geometric mean titer of E11 were very low, so a large proportion of newborns are susceptible to E11. The circulation of E11 was low after 2019 in Taiwan. A large cohort of immune naïve newborns existed curr…
View article: Viral dynamics of SARS-CoV-2 Omicron infections in a previously low COVID-19 prevalence region: Effects of vaccination status, antiviral agents, and age
Viral dynamics of SARS-CoV-2 Omicron infections in a previously low COVID-19 prevalence region: Effects of vaccination status, antiviral agents, and age Open
Our study demonstrated the primary viral infection dynamics of the Omicron variant in hospitalized patients. Vaccination significantly affected viral dynamics, and antiviral agents modified viral dynamics irrespective of vaccination status…
View article: Clinical characteristics of hospitalized children with community-acquired pneumonia and respiratory infections: Using machine learning approaches to support pathogen prediction at admission
Clinical characteristics of hospitalized children with community-acquired pneumonia and respiratory infections: Using machine learning approaches to support pathogen prediction at admission Open
We demonstrate how artificial intelligence can assist clinicians identify potential pathogens associated with pediatric ARIs upon admission. Our models provide explainable results that could help optimize the use of diagnostic testing. Int…
View article: MOLECULAR INTERACTIONS BETWEEN NIPAH VIRUS V AND DNA DAMAGE-BINDING PROTEIN (DDB1): A COMPUTATIONAL MOLECULAR DOCKING STUDY
MOLECULAR INTERACTIONS BETWEEN NIPAH VIRUS V AND DNA DAMAGE-BINDING PROTEIN (DDB1): A COMPUTATIONAL MOLECULAR DOCKING STUDY Open
Intro: The Nipah virus (NiV) V protein has been associated with evasion of host cell interferon (IFN) signal transduction, which promotes STAT degradation by binding to DNA damage-binding protein 1 (DDB1). Recent studies have shown that th…
View article: Pediatric glomerulopathy after COVID-19 vaccination: A case series and review of the literature
Pediatric glomerulopathy after COVID-19 vaccination: A case series and review of the literature Open
This is the largest case series to date of pediatric glomerulopathy after COVID-19 vaccination. From our report, patients with either newly diagnosed or relapse of glomerulopathy after vaccination had good outcomes, and receiving vaccinati…
View article: Clinical manifestations and risk factors of campylobacter gastroenteritis in children in Taiwan
Clinical manifestations and risk factors of campylobacter gastroenteritis in children in Taiwan Open
Shorter vomiting duration, bloody and mucoid stool, and less elevated AST levels are manifestations suggestive of campylobacteriosis. Risk factors of campylobacteriosis were low parental educational attainment, direct contact with acute ga…