Khayrya A. Youssif
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View article: Antiviral potential of Corchorus olitorius fixed oil loaded into poly(D,L-lactide-co-glycolide)/poly(ε-caprolactone) (PLGA/PCL) nanoparticles against HSV-1 virus, supported by network analysis
Antiviral potential of Corchorus olitorius fixed oil loaded into poly(D,L-lactide-co-glycolide)/poly(ε-caprolactone) (PLGA/PCL) nanoparticles against HSV-1 virus, supported by network analysis Open
View article: <i>Washingtonia robusta</i> H. Wendl Leaf Metabolites Potentiate the Radiosensitivity of Hepatocellular Carcinoma Through Ki67 and PARP Inhibition
<i>Washingtonia robusta</i> H. Wendl Leaf Metabolites Potentiate the Radiosensitivity of Hepatocellular Carcinoma Through Ki67 and PARP Inhibition Open
Objectives: Hepatocellular carcinoma (HCC) represents the third-most prevalent cancer in humans worldwide. The current study’s objective is to search for the potentiality of Washingtonia robusta H. Wendl ( W. robusta) leaf extract in a nan…
View article: Antimicrobial Activity of Arthrospira platensis-Mediated Gold Nanoparticles against Streptococcus pneumoniae: A Metabolomic and Docking Study
Antimicrobial Activity of Arthrospira platensis-Mediated Gold Nanoparticles against Streptococcus pneumoniae: A Metabolomic and Docking Study Open
The emergence of antibiotic-resistant Streptococcus pneumoniae necessitates the discovery of novel therapeutic agents. This study investigated the antimicrobial potential of green-synthesized gold nanoparticles (AuNPs) fabricated using Art…
View article: Metabolomics of the secondary metabolites of Ammi visnaga L. roots (family Apiaceae) and evaluation of their biological potential
Metabolomics of the secondary metabolites of Ammi visnaga L. roots (family Apiaceae) and evaluation of their biological potential Open
Recent scientific advancements in biotechnological, nanobiotechnological, and omics approaches have blossomed into a plethora of applications that hold the potential to revolutionize natural product-based drug discovery. In this context, t…
View article: An In Vitro and In Silico Study of the Enhanced Antiproliferative and Pro-Oxidant Potential of Olea europaea L. cv. Arbosana Leaf Extract via Elastic Nanovesicles (Spanlastics)
An In Vitro and In Silico Study of the Enhanced Antiproliferative and Pro-Oxidant Potential of Olea europaea L. cv. Arbosana Leaf Extract via Elastic Nanovesicles (Spanlastics) Open
The olive tree is a venerable Mediterranean plant and often used in traditional medicine. The main aim of the present study was to evaluate the effect of Olea europaea L. cv. Arbosana leaf extract (OLE) and its encapsulation within a spanl…
View article: Comparative study of the chemical composition and anti-proliferative activities of the aerial parts and roots of Apium graveolens L. (celery) and their biogenic nanoparticles
Comparative study of the chemical composition and anti-proliferative activities of the aerial parts and roots of Apium graveolens L. (celery) and their biogenic nanoparticles Open
View article: Strawberry and Ginger Silver Nanoparticles as Potential Inhibitors for SARS-CoV-2 Assisted by In Silico Modeling and Metabolic Profiling
Strawberry and Ginger Silver Nanoparticles as Potential Inhibitors for SARS-CoV-2 Assisted by In Silico Modeling and Metabolic Profiling Open
SARS-CoV-2 (COVID-19), a novel coronavirus causing life-threatening pneumonia, caused a pandemic starting in 2019 and caused unprecedented economic and health crises all over the globe. This requires the rapid discovery of anti-SARS-CoV-2 …
View article: Cytotoxic potential of Allium sativum L. roots and their green synthesized nanoparticles supported with metabolomics and molecular docking analyses
Cytotoxic potential of Allium sativum L. roots and their green synthesized nanoparticles supported with metabolomics and molecular docking analyses Open
Allium sativum L. (garlic) has received a growing interest as both a food plant and folk remedy with promising antitumor and chemopreventive potential. So far, a large body of research has been conducted on garlic, mostly focusing on the b…
View article: Cytotoxic Potential, Metabolic Profiling, and Liposomes of Coscinoderma sp. Crude Extract Supported by in silico Analysis
Cytotoxic Potential, Metabolic Profiling, and Liposomes of Coscinoderma sp. Crude Extract Supported by in silico Analysis Open
Encapsulation of both the hydrophilic and the lipophilic components of the extract within the lipid-based nanovesicles enhanced the cellular uptake and accessibility of the entrapped cargo. This study introduces liposomal nano-vesicles as …
View article: Cnicin as an Anti-SARS-CoV-2: An Integrated In Silico and In Vitro Approach for the Rapid Identification of Potential COVID-19 Therapeutics
Cnicin as an Anti-SARS-CoV-2: An Integrated In Silico and In Vitro Approach for the Rapid Identification of Potential COVID-19 Therapeutics Open
Since the emergence of the SARS-CoV-2 pandemic in 2019, it has remained a significant global threat, especially with the newly evolved variants. Despite the presence of different COVID-19 vaccines, the discovery of proper antiviral therape…
View article: Antiulcer Potential of Olea europea L. cv. Arbequina Leaf Extract Supported by Metabolic Profiling and Molecular Docking
Antiulcer Potential of Olea europea L. cv. Arbequina Leaf Extract Supported by Metabolic Profiling and Molecular Docking Open
Gastric ulceration is among the most serious humanpublic health problems. Olea europea L. cv. Arbequina is one of the numerous olive varieties which have scarcely been studied. The reported antioxidant and anti-inflammatory potential of th…
View article: Potential Anticancer Lipoxygenase Inhibitors from the Red Sea-Derived Brown Algae Sargassum cinereum: An In-Silico-Supported In-Vitro Study
Potential Anticancer Lipoxygenase Inhibitors from the Red Sea-Derived Brown Algae Sargassum cinereum: An In-Silico-Supported In-Vitro Study Open
LC-MS-assisted metabolomic profiling of the Red Sea-derived brown algae Sargassum cinereum “Sargassaceae” dereplicated eleven compounds 1–11. Further phytochemical investigation afforded two new aryl cresol 12–13, along with eight known co…
View article: Holospiniferoside: A New Antitumor Cerebroside from The Red Sea Cucumber Holothuria spinifera: In Vitro and In Silico Studies
Holospiniferoside: A New Antitumor Cerebroside from The Red Sea Cucumber Holothuria spinifera: In Vitro and In Silico Studies Open
Chemical investigation of the methanolic extract of the Red Sea cucumber Holothuria spinifera led to the isolation of a new cerebroside, holospiniferoside (1), together with thymidine (2), methyl-α-d-glucopyranoside (3), a new triacylglyce…
View article: New 5-LOX and 15-LOX Inhibitors Isolated from Red Sea Derived Brown Alga Sarragassum Cinnerum: An In Silico-Supported Study
New 5-LOX and 15-LOX Inhibitors Isolated from Red Sea Derived Brown Alga Sarragassum Cinnerum: An In Silico-Supported Study Open
Sargassum is a brown algal genus inhabiting tropical region. Metabolomic profiling of Sarragassum cinnerum “ Sargassaceae ” , dereplicated eleven compounds 1-11 , further phytochemical investigation afforded two new aryl cresol 12-13 , alo…
View article: Sterols and Triterpenes: Antiviral Potential Supported by In-Silico Analysis
Sterols and Triterpenes: Antiviral Potential Supported by In-Silico Analysis Open
The acute respiratory syndrome caused by the novel coronavirus (SARS-CoV-2) caused severe panic all over the world. The coronavirus (COVID-19) outbreak has already brought massive human suffering and major economic disruption and unfortuna…
View article: New Cytotoxic Cerebrosides from the Red Sea Cucumber Holothuria spinifera Supported by In-Silico Studies
New Cytotoxic Cerebrosides from the Red Sea Cucumber Holothuria spinifera Supported by In-Silico Studies Open
Bioactivity-guided fractionation of a methanolic extract of the Red Sea cucumber Holothuria spinifera and LC-HRESIMS-assisted dereplication resulted in the isolation of four compounds, three new cerebrosides, spiniferosides A (1), B (2), a…
View article: Inhibition of SARS-CoV-2 main protease by phenolic compounds from <i>Manilkara hexandra</i> (Roxb.) Dubard assisted by metabolite profiling and <i>in silico</i> virtual screening
Inhibition of SARS-CoV-2 main protease by phenolic compounds from <i>Manilkara hexandra</i> (Roxb.) Dubard assisted by metabolite profiling and <i>in silico</i> virtual screening Open
SARS-CoV-2 is a novel coronavirus that was first identified during the outbreak in Wuhan, China in 2019.
View article: Anti-Alzheimer potential, metabolomic profiling and molecular docking of green synthesized silver nanoparticles of Lampranthus coccineus and Malephora lutea aqueous extracts
Anti-Alzheimer potential, metabolomic profiling and molecular docking of green synthesized silver nanoparticles of Lampranthus coccineus and Malephora lutea aqueous extracts Open
The green synthesis of silver nanoparticles (SNPs) using plant extracts is an eco-friendly method. It is a single step and offers several advantages such as time reducing, cost-effective and environmental non-toxic. Silver nanoparticles ar…
View article: A Phytochemical and Biological Review on Plants of The family Aizoaceae
A Phytochemical and Biological Review on Plants of The family Aizoaceae Open
Objectives: This study is aimed to be a comprehensive review of the phytochemical constituents and biological activities of Aizoaceae family plants (Mesembryanthemaceae). Methods: This study is covering articles between 1969 and 2018, revi…
View article: <p>Antiviral potential of green synthesized silver nanoparticles of <em>Lampranthus coccineus</em> and <em>Malephora lutea</em></p>
Antiviral potential of green synthesized silver nanoparticles of <em>Lampranthus coccineus</em> and <em>Malephora lutea</em> Open
These results highlight that SNPs of L. coccineus and M. lutea could have antiviral activity against HSV-1, HAV-10, and CoxB4 virus.
View article: Quality Control of Herbal Products in the Egyptian Market Used for Some Gastro-Intestinal Tract Disorders
Quality Control of Herbal Products in the Egyptian Market Used for Some Gastro-Intestinal Tract Disorders Open
This study aimed to evaluate the quality of three commercial herbal tea products present in the Egyptian market; commercial herbal Calm (1), commercial herbal Intestinal (2) and commercial herbal Anti diarrhea (3) in comparison with three …