Moazzam Shahzad
YOU?
Author Swipe
View article: Comparative safety and efficacy of tislelizumab-based regimens versus chemotherapy in lung cancer: a systematic review and meta-analysis
Comparative safety and efficacy of tislelizumab-based regimens versus chemotherapy in lung cancer: a systematic review and meta-analysis Open
Background Lung cancer is the leading cause of cancer-related mortality worldwide, with its burden expected to rise significantly by 2025. Despite therapeutic advances, survival rates remain low, and comorbidities further complicate manage…
View article: Trends and disparities in immune thrombocytopenic purpura-related mortality in the United States: a retrospective study over 24 years
Trends and disparities in immune thrombocytopenic purpura-related mortality in the United States: a retrospective study over 24 years Open
The disparities identified in our analysis, particularly among NH Whites, the elderly, and residents of the Midwest and rural areas, suggest underlying healthcare access issues, potential genetic predispositions, and regional differences i…
View article: Upfront Immunotherapy Approaches in the Management of Adults with Acute Lymphoblastic Leukemia
Upfront Immunotherapy Approaches in the Management of Adults with Acute Lymphoblastic Leukemia Open
The therapeutic landscape of adults with B-cell precursor acute lymphoblastic leukemia (BCP-ALL) is undergoing a paradigm shift, driven by the development of immunotherapy-based “chemo-free” and “chemo-light’ regimens. These strategies aim…
View article: Concurrent intravenous immunoglobulin and platelet transfusion for refractory alloimmune thrombocytopenia in patients undergoing allogeneic hematopoietic stem cell transplantation
Concurrent intravenous immunoglobulin and platelet transfusion for refractory alloimmune thrombocytopenia in patients undergoing allogeneic hematopoietic stem cell transplantation Open
Continuous intravenous immunoglobulin and platelet infusions over 48 h may be able to overcome life-threatening refractory alloimmune thrombocytopenia in transplant patients and may provide a bridging measure until platelet engraftment or …
View article: Impact of Measurable Residual Disease Status on Outcomes After HLA-Matched Donor Allogeneic Hematopoietic Cell Transplantation in Acute Myeloid Leukemia
Impact of Measurable Residual Disease Status on Outcomes After HLA-Matched Donor Allogeneic Hematopoietic Cell Transplantation in Acute Myeloid Leukemia Open
Pretransplant MRD status predicts post-allo-HCT outcomes, with MRD positivity associated with reduced overall and disease-free survival and increased relapse risk. Personalized MRD-directed strategies are needed to optimize outcomes in AML…
View article: Outcomes of Allogeneic Hematopoietic Stem Cell Transplantation in Older Patients Aged 65 Years and Above With Myelofibrosis
Outcomes of Allogeneic Hematopoietic Stem Cell Transplantation in Older Patients Aged 65 Years and Above With Myelofibrosis Open
In myelofibrosis patients aged 65 years and above undergoing allogeneic HCT, a favorable 2-year overall survival of 62% was noted with an inferior DFS compared to younger patients, while other post-transplant outcomes remained comparable. …
View article: Clinical and Biological Factors Affecting Left Ventricular End-Diastolic Pressure in ST-Segment Elevation Myocardial Infarction
Clinical and Biological Factors Affecting Left Ventricular End-Diastolic Pressure in ST-Segment Elevation Myocardial Infarction Open
Objective: To determine the clinical & biological factors affecting Left Ventricular End Diastolic Pressure(LVEDP) in ST-Segment Elevation Myocardial Infarction (STEMI) patients undergoing coronary angiography followed by Primary Percutane…
View article: Association of Pathologic Response and Adjuvant Chemotherapy with Survival in Resected Pancreatic Ductal Adenocarcinoma Following Neoadjuvant Therapy
Association of Pathologic Response and Adjuvant Chemotherapy with Survival in Resected Pancreatic Ductal Adenocarcinoma Following Neoadjuvant Therapy Open
Background: In patients with curatively resected pancreatic adenocarcinoma who have undergone neoadjuvant chemotherapy (NACT), evidence supporting the benefit of additional adjuvant chemotherapy (ACT) remains limited. We aim to identify fa…
View article: Exploring thermal and entropic behaviors in nanofluid stagnation point flow with nonlinear dynamics
Exploring thermal and entropic behaviors in nanofluid stagnation point flow with nonlinear dynamics Open
This study investigates the optimization of heat and mass transfer in nanofluid stagnation point flow by analyzing entropy generation and its underlying physical mechanisms. Nanofluid technology, widely applied in thermal energy storage, a…
View article: What have we learned about TP53-mutated acute myeloid leukemia?
What have we learned about TP53-mutated acute myeloid leukemia? Open
TP53 is a tumor suppressor gene frequently mutated in human cancers and is generally associated with poor outcomes. TP53 mutations are found in approximately 5% to 10% of patients with de novo acute myeloid leukemia (AML), more frequently …
View article: Outcomes with chimeric antigen receptor T-cell therapy in Rheumatological disorders: A systematic review
Outcomes with chimeric antigen receptor T-cell therapy in Rheumatological disorders: A systematic review Open
CAR-T cell therapy is a paradigm shift in managing rheumatologic diseases, with symptomatic improvement and biochemical control of these diseases. Although preliminary evidence indicates promising results, long-term follow-up and prospecti…
View article: Efficacy of Ruxolitinib with corticosteroids in idiopathic pneumonia syndrome post-allogeneic hematopoietic stem cell transplantation: A single-center experience and systematic review
Efficacy of Ruxolitinib with corticosteroids in idiopathic pneumonia syndrome post-allogeneic hematopoietic stem cell transplantation: A single-center experience and systematic review Open
The combination of Ruxolitinib and CS for treating IPS post-allo-HSCT suggested promising results in the case series, with favorable response and improved survival by blocking the cytokine production contributing to IPS. The significant mo…
View article: Outcomes with Allogeneic Hematopoietic Stem Cell Transplantation in Therapy Related Myeloid Neoplasms: A Systematic Review and Meta-Analysis
Outcomes with Allogeneic Hematopoietic Stem Cell Transplantation in Therapy Related Myeloid Neoplasms: A Systematic Review and Meta-Analysis Open
In this meta-analysis and systematic review, 7785 patients from 33 original studies reporting outcomes of therapy- related myeloid neoplasms (t-MN) including therapy-related acute myeloid leukemia (t-AML) and therapy-related myelodysplasti…
View article: The Impact of Early-to-Moderate Stage Chronic Kidney Disease on Hospitalization Outcomes in Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplant: A Nationwide Analysis Using the National Inpatient Sample Database (2002–2019)
The Impact of Early-to-Moderate Stage Chronic Kidney Disease on Hospitalization Outcomes in Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplant: A Nationwide Analysis Using the National Inpatient Sample Database (2002–2019) Open
Many patients with a hematologic malignancy have other pre-existing conditions at the time of consideration of an allogeneic stem cell transplant (allo-HSCT). Among these, mild-to-moderate chronic kidney disease (CKD) is a common comorbid …
View article: Addressing Racial Disparities in Clinical Trials in Cholangiocarcinoma
Addressing Racial Disparities in Clinical Trials in Cholangiocarcinoma Open
BACKGROUNDTo develop effective novel treatment strategies for Cholangiocarcinoma that cater to patients from diverse backgrounds, all racial groups must have equal opportunities to participate in clinical trials.
View article: Successful treatment with fludarabine and cyclophosphamide in a VEXAS syndrome patient with associated myelodysplastic syndrome: a case report and systematic review
Successful treatment with fludarabine and cyclophosphamide in a VEXAS syndrome patient with associated myelodysplastic syndrome: a case report and systematic review Open
Vacuoles, E1 syndrome, X-linked, autoinflammatory, somatic (VEXAS) syndrome is a chronic inflammatory disorder that affects various organ systems. It is associated with hematologic malignancies and is generally refractory to therapies. All…
View article: Use of Endpoints in Phase III Randomized Controlled Trials for Hematopoietic Stem Cell Transplantation Over the Last 15 Years: A Systematic Review
Use of Endpoints in Phase III Randomized Controlled Trials for Hematopoietic Stem Cell Transplantation Over the Last 15 Years: A Systematic Review Open
This systematic review aimed to evaluate the proportion of primary and secondary endpoints in hematopoietic stem cell transplant (HSCT) phase III randomized clinical trials (RCTs) and analyze their trends in time and study sponsorship stat…
View article: Predictors of cytomegalovirus reactivation after allogeneic hematopoietic cell transplantation: Insights from a real-world experience
Predictors of cytomegalovirus reactivation after allogeneic hematopoietic cell transplantation: Insights from a real-world experience Open
CMV disease leads to significantly inferior survival after an allogeneic hematopoietic cell transplantation. Recipient CMV seropositive status was associated with the risk of CMV viremia and CMV disease, and this was not abrogated with the…
View article: Outcomes with allogeneic hematopoietic stem cell transplantation in TP53-mutated myelodysplastic syndrome: A systematic review and meta-analysis
Outcomes with allogeneic hematopoietic stem cell transplantation in TP53-mutated myelodysplastic syndrome: A systematic review and meta-analysis Open
We conducted a systematic review and meta-analysis to evaluate outcomes after allogeneic hematopoietic stem cell transplantation (Allo-HSCT) in TP53-mutated myelodysplastic syndromes (MDS). A literature search was performed on PubMed, Coch…
View article: Correction to: The immune regulatory function of B7-H3 in malignancy: spotlight on the IFN-STAT1 axis and regulation of tumor-associated macrophages
Correction to: The immune regulatory function of B7-H3 in malignancy: spotlight on the IFN-STAT1 axis and regulation of tumor-associated macrophages Open
View article: POSTER: MDS-392 Outcomes With Allogeneic Hematopoietic Stem Cell Transplant in Therapy-Related Myelodysplastic Neoplasms: A Systematic Review and Meta-Analysis
POSTER: MDS-392 Outcomes With Allogeneic Hematopoietic Stem Cell Transplant in Therapy-Related Myelodysplastic Neoplasms: A Systematic Review and Meta-Analysis Open
View article: MDS-392 Outcomes With Allogeneic Hematopoietic Stem Cell Transplant in Therapy-Related Myelodysplastic Neoplasms: A Systematic Review and Meta-Analysis
MDS-392 Outcomes With Allogeneic Hematopoietic Stem Cell Transplant in Therapy-Related Myelodysplastic Neoplasms: A Systematic Review and Meta-Analysis Open
View article: AML-414 Nationwide Trends of Palliative Care Input Among Hospitalized Patients With Acute Myeloid Leukemia at Academic Centers
AML-414 Nationwide Trends of Palliative Care Input Among Hospitalized Patients With Acute Myeloid Leukemia at Academic Centers Open
View article: Clinical Research in Chronic Lymphocytic Leukemia in Pakistan; A Systematic Review
Clinical Research in Chronic Lymphocytic Leukemia in Pakistan; A Systematic Review Open
Background: Significant advances have been made in the treatment of chronic lymphocytic leukemia (CLL) since the turn of the new millennium. However, most clinical trials were done in developed countries where minority ethnicities were und…
View article: PB2092: INCIDENCE AND RISK FACTORS ASSOCIATED WITH BLEEDING FOLLOWING ANTI-B CELL MATURATION ANTIGEN CHIMERIC ANTIGEN RECEPTOR T-CELL THERAPY IN PATIENTS WITH RELAPSED/REFRACTORY MULTIPLE MYELOMA
PB2092: INCIDENCE AND RISK FACTORS ASSOCIATED WITH BLEEDING FOLLOWING ANTI-B CELL MATURATION ANTIGEN CHIMERIC ANTIGEN RECEPTOR T-CELL THERAPY IN PATIENTS WITH RELAPSED/REFRACTORY MULTIPLE MYELOMA Open
Topic: 14. Myeloma and other monoclonal gammopathies - Clinical Background: Bleeding and thrombotic events are an emerging toxicity associated with chimeric antigen receptor (CAR) T-cell therapies. In lymphoma patients treated with axicabt…
View article: P-114 The therapeutic potential of nuclear receptor RORy in hepatocellular carcinoma
P-114 The therapeutic potential of nuclear receptor RORy in hepatocellular carcinoma Open
View article: Outcomes with chimeric antigen receptor t-cell therapy in relapsed or refractory acute myeloid leukemia: a systematic review and meta-analysis
Outcomes with chimeric antigen receptor t-cell therapy in relapsed or refractory acute myeloid leukemia: a systematic review and meta-analysis Open
Background We conducted a systematic review and meta-analysis to evaluate outcomes following chimeric antigen receptor T cell (CAR-T) therapy in relapsed/refractory acute myeloid leukemia (RR-AML). Methods We performed a literature search …
View article: Lessons Learned from COVID-19 Pandemic: Outcomes after Sars-Cov-2 Infection in Hematopoietic Cell Transplant and Cell Therapy Recipients
Lessons Learned from COVID-19 Pandemic: Outcomes after Sars-Cov-2 Infection in Hematopoietic Cell Transplant and Cell Therapy Recipients Open
View article: Increased risk of eclampsia and preeclampsia during delivery hospitalizations in women with beta-thalassemia; An analysis of the National Inpatient Sample database
Increased risk of eclampsia and preeclampsia during delivery hospitalizations in women with beta-thalassemia; An analysis of the National Inpatient Sample database Open
View article: Lessons Learned from COVID-19 Pandemic: Outcomes after Sars-Cov-2 Infection in Hematopoietic Cell Transplant and Cell Therapy Recipients
Lessons Learned from COVID-19 Pandemic: Outcomes after Sars-Cov-2 Infection in Hematopoietic Cell Transplant and Cell Therapy Recipients Open
Background: Coronavirus disease 2019 (COVID-19), a respiratory illness caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was declared a pandemic in March 2020. Over 500 million cases of SARS-CoV-2 have been …