Khyatiben V. Pathak
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View article: Immunometabolic determinants of long-term response in leukemia patients receiving CD19 CAR T cell therapy
Immunometabolic determinants of long-term response in leukemia patients receiving CD19 CAR T cell therapy Open
Although most patients with relapsed/refractory B-cell acute lymphoblastic leukemia (B-ALL) receiving CD19-targeted chimeric antigen receptor (CAR) T cell therapy achieve remission, loss of CAR T cell functionality and subsequent relapse r…
View article: Elevated Microbially-Derived Metabolites in Autism: A Possible Diagnostic Screening Test for a Distinct ASD Phenotype
Elevated Microbially-Derived Metabolites in Autism: A Possible Diagnostic Screening Test for a Distinct ASD Phenotype Open
View article: Urban Versus Rural Disparities in Alcoholic Liver Disease Mortality: A Comprehensive 22-Year Analysis of Trends and Demographic Influences in the United States
Urban Versus Rural Disparities in Alcoholic Liver Disease Mortality: A Comprehensive 22-Year Analysis of Trends and Demographic Influences in the United States Open
Introduction Alcoholic liver disease (ALD) encompasses a spectrum of liver conditions that result from excessive alcohol consumption. Disparities in mortality rates of ALD between urban and rural populations have become a growing concern, …
View article: Exploring Public Interest in Atrial Fibrillation and Its Treatment Measures: A Google Trends Analysis
Exploring Public Interest in Atrial Fibrillation and Its Treatment Measures: A Google Trends Analysis Open
This study demonstrates a rising public interest in AF. Searches related to medications such as amiodarone, metoprolol, diltiazem, and flecainide, as well as procedures including cardioversion, artificial cardiac pacemaker, and left atrial…
View article: Unclogging the heart: the potential of statins to reverse coronary artery blockage
Unclogging the heart: the potential of statins to reverse coronary artery blockage Open
Acute coronary syndrome (ACS) comprises three life-threatening cardiovascular conditions-unstable angina, non-ST elevation myocardial infarction (NSTEMI), and ST elevation myocardial infarction (STEMI)-all characterized by reduced myocardi…
View article: Correction: AOH1996 targets mitochondrial dynamics and metabolism in leukemic stem cells via mitochondrial PCNA inhibition
Correction: AOH1996 targets mitochondrial dynamics and metabolism in leukemic stem cells via mitochondrial PCNA inhibition Open
View article: Targeting RNA modification and mitochondrial metabolism cross talk in leukemic stem cells with CDK7 inhibitor TGN-1062
Targeting RNA modification and mitochondrial metabolism cross talk in leukemic stem cells with CDK7 inhibitor TGN-1062 Open
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View article: Serum metabolomics signatures after an acute bout of combined traditional or high-intensity tactical training in young males and females
Serum metabolomics signatures after an acute bout of combined traditional or high-intensity tactical training in young males and females Open
Exercise is a multipotent stimulus that results in large-scale dynamic changes to the systemic molecular profile. Alternative exercise prescriptions and doses would be expected to result in distinct signatures due to differences in duratio…
View article: Figure S4 from Immunometabolic Adaptation of CD19-Targeted CAR T Cells in the Central Nervous System Microenvironment of Patients Promotes Memory Development
Figure S4 from Immunometabolic Adaptation of CD19-Targeted CAR T Cells in the Central Nervous System Microenvironment of Patients Promotes Memory Development Open
Figure S4. Patients’ CD8+ CAR T cells spatiotemporal metabolic state.
View article: Table S4 from Immunometabolic Adaptation of CD19-Targeted CAR T Cells in the Central Nervous System Microenvironment of Patients Promotes Memory Development
Table S4 from Immunometabolic Adaptation of CD19-Targeted CAR T Cells in the Central Nervous System Microenvironment of Patients Promotes Memory Development Open
Supplementary Table 4: Metabolomics analysis of patients’ day 28 CSF and CSF from pooled donors.
View article: Table S2 from Immunometabolic Adaptation of CD19-Targeted CAR T Cells in the Central Nervous System Microenvironment of Patients Promotes Memory Development
Table S2 from Immunometabolic Adaptation of CD19-Targeted CAR T Cells in the Central Nervous System Microenvironment of Patients Promotes Memory Development Open
Supplementary Table 2: A mass cytometry integrative panel with antibodies specific for CAR, cell lineage, metabolic, activation and maturation, proliferation, cell signaling and regulation, and immune checkpoint proteins involved in CAR T …
View article: Table S1 from Immunometabolic Adaptation of CD19-Targeted CAR T Cells in the Central Nervous System Microenvironment of Patients Promotes Memory Development
Table S1 from Immunometabolic Adaptation of CD19-Targeted CAR T Cells in the Central Nervous System Microenvironment of Patients Promotes Memory Development Open
Supplementary Table 1. Patients’ demographic and clinical characteristics.
View article: Figure S6 from Immunometabolic Adaptation of CD19-Targeted CAR T Cells in the Central Nervous System Microenvironment of Patients Promotes Memory Development
Figure S6 from Immunometabolic Adaptation of CD19-Targeted CAR T Cells in the Central Nervous System Microenvironment of Patients Promotes Memory Development Open
Figure S6. Comparison of pooled human CSF and patients’ day 28 CSF.
View article: Figure S6 from Immunometabolic Adaptation of CD19-Targeted CAR T Cells in the Central Nervous System Microenvironment of Patients Promotes Memory Development
Figure S6 from Immunometabolic Adaptation of CD19-Targeted CAR T Cells in the Central Nervous System Microenvironment of Patients Promotes Memory Development Open
Figure S6. Comparison of pooled human CSF and patients’ day 28 CSF.
View article: Figure S1 from Immunometabolic Adaptation of CD19-Targeted CAR T Cells in the Central Nervous System Microenvironment of Patients Promotes Memory Development
Figure S1 from Immunometabolic Adaptation of CD19-Targeted CAR T Cells in the Central Nervous System Microenvironment of Patients Promotes Memory Development Open
Figure S1. Example of gating strategies to detect CAR- and CAR+ T cells.
View article: Data from Immunometabolic Adaptation of CD19-Targeted CAR T Cells in the Central Nervous System Microenvironment of Patients Promotes Memory Development
Data from Immunometabolic Adaptation of CD19-Targeted CAR T Cells in the Central Nervous System Microenvironment of Patients Promotes Memory Development Open
Metabolic reprogramming is a hallmark of T-cell activation, and metabolic fitness is fundamental for T-cell–mediated antitumor immunity. Insights into the metabolic plasticity of chimeric antigen receptor (CAR) T cells in patients could he…
View article: Figure S5 from Immunometabolic Adaptation of CD19-Targeted CAR T Cells in the Central Nervous System Microenvironment of Patients Promotes Memory Development
Figure S5 from Immunometabolic Adaptation of CD19-Targeted CAR T Cells in the Central Nervous System Microenvironment of Patients Promotes Memory Development Open
Figure S5. Patients’ CAR T cell products phenotypic composition.
View article: Figure S2 from Immunometabolic Adaptation of CD19-Targeted CAR T Cells in the Central Nervous System Microenvironment of Patients Promotes Memory Development
Figure S2 from Immunometabolic Adaptation of CD19-Targeted CAR T Cells in the Central Nervous System Microenvironment of Patients Promotes Memory Development Open
Figure S2. Spatiotemporal cytokines analysis.
View article: Figure S3 from Immunometabolic Adaptation of CD19-Targeted CAR T Cells in the Central Nervous System Microenvironment of Patients Promotes Memory Development
Figure S3 from Immunometabolic Adaptation of CD19-Targeted CAR T Cells in the Central Nervous System Microenvironment of Patients Promotes Memory Development Open
Figure S3. Patients’ CD8+ CAR T cells reveal spatiotemporal metabolic rewiring.
View article: Figure S4 from Immunometabolic Adaptation of CD19-Targeted CAR T Cells in the Central Nervous System Microenvironment of Patients Promotes Memory Development
Figure S4 from Immunometabolic Adaptation of CD19-Targeted CAR T Cells in the Central Nervous System Microenvironment of Patients Promotes Memory Development Open
Figure S4. Patients’ CD8+ CAR T cells spatiotemporal metabolic state.
View article: Table S5 from Immunometabolic Adaptation of CD19-Targeted CAR T Cells in the Central Nervous System Microenvironment of Patients Promotes Memory Development
Table S5 from Immunometabolic Adaptation of CD19-Targeted CAR T Cells in the Central Nervous System Microenvironment of Patients Promotes Memory Development Open
Supplementary Table 5: A mass cytometry integrative panel with antibodies specific for CAR, cell lineage, tissue residence, differentiation, effector, and immune checkpoint proteins involved in CAR T cell function.
View article: Table S5 from Immunometabolic Adaptation of CD19-Targeted CAR T Cells in the Central Nervous System Microenvironment of Patients Promotes Memory Development
Table S5 from Immunometabolic Adaptation of CD19-Targeted CAR T Cells in the Central Nervous System Microenvironment of Patients Promotes Memory Development Open
Supplementary Table 5: A mass cytometry integrative panel with antibodies specific for CAR, cell lineage, tissue residence, differentiation, effector, and immune checkpoint proteins involved in CAR T cell function.
View article: Data from Immunometabolic Adaptation of CD19-Targeted CAR T Cells in the Central Nervous System Microenvironment of Patients Promotes Memory Development
Data from Immunometabolic Adaptation of CD19-Targeted CAR T Cells in the Central Nervous System Microenvironment of Patients Promotes Memory Development Open
Metabolic reprogramming is a hallmark of T-cell activation, and metabolic fitness is fundamental for T-cell–mediated antitumor immunity. Insights into the metabolic plasticity of chimeric antigen receptor (CAR) T cells in patients could he…
View article: Table S2 from Immunometabolic Adaptation of CD19-Targeted CAR T Cells in the Central Nervous System Microenvironment of Patients Promotes Memory Development
Table S2 from Immunometabolic Adaptation of CD19-Targeted CAR T Cells in the Central Nervous System Microenvironment of Patients Promotes Memory Development Open
Supplementary Table 2: A mass cytometry integrative panel with antibodies specific for CAR, cell lineage, metabolic, activation and maturation, proliferation, cell signaling and regulation, and immune checkpoint proteins involved in CAR T …
View article: Figure S7 from Immunometabolic Adaptation of CD19-Targeted CAR T Cells in the Central Nervous System Microenvironment of Patients Promotes Memory Development
Figure S7 from Immunometabolic Adaptation of CD19-Targeted CAR T Cells in the Central Nervous System Microenvironment of Patients Promotes Memory Development Open
Figure S7. Growth curve of CAR T cells produced in RPMI or CSF; n = 7 patients.
View article: Figure S5 from Immunometabolic Adaptation of CD19-Targeted CAR T Cells in the Central Nervous System Microenvironment of Patients Promotes Memory Development
Figure S5 from Immunometabolic Adaptation of CD19-Targeted CAR T Cells in the Central Nervous System Microenvironment of Patients Promotes Memory Development Open
Figure S5. Patients’ CAR T cell products phenotypic composition.
View article: Figure S1 from Immunometabolic Adaptation of CD19-Targeted CAR T Cells in the Central Nervous System Microenvironment of Patients Promotes Memory Development
Figure S1 from Immunometabolic Adaptation of CD19-Targeted CAR T Cells in the Central Nervous System Microenvironment of Patients Promotes Memory Development Open
Figure S1. Example of gating strategies to detect CAR- and CAR+ T cells.
View article: Table S1 from Immunometabolic Adaptation of CD19-Targeted CAR T Cells in the Central Nervous System Microenvironment of Patients Promotes Memory Development
Table S1 from Immunometabolic Adaptation of CD19-Targeted CAR T Cells in the Central Nervous System Microenvironment of Patients Promotes Memory Development Open
Supplementary Table 1. Patients’ demographic and clinical characteristics.
View article: Figure S3 from Immunometabolic Adaptation of CD19-Targeted CAR T Cells in the Central Nervous System Microenvironment of Patients Promotes Memory Development
Figure S3 from Immunometabolic Adaptation of CD19-Targeted CAR T Cells in the Central Nervous System Microenvironment of Patients Promotes Memory Development Open
Figure S3. Patients’ CD8+ CAR T cells reveal spatiotemporal metabolic rewiring.
View article: Table S3 from Immunometabolic Adaptation of CD19-Targeted CAR T Cells in the Central Nervous System Microenvironment of Patients Promotes Memory Development
Table S3 from Immunometabolic Adaptation of CD19-Targeted CAR T Cells in the Central Nervous System Microenvironment of Patients Promotes Memory Development Open
Supplementary Table 3: Metabolomics analysis of patients’ matched CSF and PB samples on day 28 post-infusion.