Ki Sueng Choi
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View article: Neuroanatomical dimensions in major depression linked to cognition, adverse life events, self-harm, metabolomics and genetics
Neuroanatomical dimensions in major depression linked to cognition, adverse life events, self-harm, metabolomics and genetics Open
D1 and D2 represent distinct neurobiological mechanisms underlying MDD. The validation in a general population-based cohort and in a cohort sample with depressive symptoms delineates mechanisms underlying heterogeneity in MDD.
View article: Electrophysiological Biomarkers Reflect Target Engagement and Response Using Deep Brain Stimulation for Obsessive-Compulsive Disorder
Electrophysiological Biomarkers Reflect Target Engagement and Response Using Deep Brain Stimulation for Obsessive-Compulsive Disorder Open
These findings suggest that intraoperative EPs provide valuable insights into ALIC DBS target engagement. EP characteristics may serve as biomarkers to refine DBS targeting and predict clinical response, offering a potential tool for optim…
View article: Neurophysiological correlates of neuroanatomical dimensions in major depressive disorder: EEG markers of brain function and treatment outcome
Neurophysiological correlates of neuroanatomical dimensions in major depressive disorder: EEG markers of brain function and treatment outcome Open
Major depressive disorder (MDD) is a heterogeneous disorder with variable treatment responses and no established biomarkers for identification or predictors of treatment response. In the COORDINATE-MDD consortium, a data-driven classificat…
View article: Functional Evidence for Substantia Nigra Pars Reticulata Involvement in Auditory Verbal Hallucinations in Treatment-Resistant Schizophrenia
Functional Evidence for Substantia Nigra Pars Reticulata Involvement in Auditory Verbal Hallucinations in Treatment-Resistant Schizophrenia Open
Auditory verbal hallucinations (AVH) in treatment-resistant schizophrenia (TR SZ) are often unresponsive to pharmacologic interventions, necessitating novel therapeutic approaches. We report a case of a patient with persistent AVH who unde…
View article: Corrigendum: Proceedings of the 12th annual deep brain stimulation think tank: cutting edge technology meets novel applications
Corrigendum: Proceedings of the 12th annual deep brain stimulation think tank: cutting edge technology meets novel applications Open
[This corrects the article DOI: 10.3389/fnhum.2025.1544994.].
View article: Effective Stimulation Sites and Networks for Substantia Nigra Pars Reticulata Deep Brain Stimulation for Auditory Verbal Hallucinations in Schizophrenia
Effective Stimulation Sites and Networks for Substantia Nigra Pars Reticulata Deep Brain Stimulation for Auditory Verbal Hallucinations in Schizophrenia Open
Deep brain stimulation (DBS) of the substantia nigra pars reticulata (SNpr) is under investigation for managing auditory-verbal hallucinations (AVH) in treatment-resistant schizophrenia (TR-SZ). We assessed acute AVH suppression during ini…
View article: Neuroanatomical dimensions in major depression: external validation and links with cognition, adverse life events, self-harm, metabolomics and genetics
Neuroanatomical dimensions in major depression: external validation and links with cognition, adverse life events, self-harm, metabolomics and genetics Open
Major depressive disorder (MDD) is a leading cause of disability worldwide, yet its diagnosis relies on clinical symptoms alone. Using machine learning applied to deeply phenotyped, medication-free participants with MDD, we identified two …
View article: Proceedings of the 12th annual deep brain stimulation think tank: cutting edge technology meets novel applications
Proceedings of the 12th annual deep brain stimulation think tank: cutting edge technology meets novel applications Open
The Deep Brain Stimulation (DBS) Think Tank XII was held on August 21st to 23rd. This year we showcased groundbreaking advancements in neuromodulation technology, focusing heavily on the novel uses of existing technology as well as next-ge…
View article: Association of Bile Acids with Connectivity of Executive Control and Default Mode Networks in Patients with Major Depression
Association of Bile Acids with Connectivity of Executive Control and Default Mode Networks in Patients with Major Depression Open
Objective Bile acids may contribute to pathophysiologic markers of Alzheimer’s disease, including disruptions of the executive control network (ECN) and the default mode network (DMN). Cognitive dysfunction is common in major depressive di…
View article: Neural Interoceptive Processing Is Modulated by Deep Brain Stimulation to Subcallosal Cingulate Cortex for Treatment-Resistant Depression
Neural Interoceptive Processing Is Modulated by Deep Brain Stimulation to Subcallosal Cingulate Cortex for Treatment-Resistant Depression Open
Brain-based evidence implies an interoceptive element in the mechanism of treatment efficacy with DBS for treatment-resistant depression and substantiates a theorized connection between interoception and depression.
View article: BSNMani: Bayesian Scalar-on-network Regression with Manifold Learning
BSNMani: Bayesian Scalar-on-network Regression with Manifold Learning Open
Brain connectivity analysis is crucial for understanding brain structure and neurological function, shedding light on the mechanisms of mental illness. To study the association between individual brain connectivity networks and the clinica…
View article: Deep brain stimulation induces white matter remodeling and functional changes to brain-wide networks
Deep brain stimulation induces white matter remodeling and functional changes to brain-wide networks Open
Deep brain stimulation (DBS) is an emerging therapeutic option for treatment resistant neurological and psychiatric disorders, most notably depression. Despite this, little is known about the anatomical and functional mechanisms that under…
View article: Subcallosal cingulate deep brain stimulation evokes two distinct cortical responses via differential white matter activation
Subcallosal cingulate deep brain stimulation evokes two distinct cortical responses via differential white matter activation Open
Subcallosal cingulate (SCC) deep brain stimulation (DBS) is an emerging therapy for refractory depression. Good clinical outcomes are associated with the activation of white matter adjacent to the SCC. This activation produces a signature …
View article: A dual-circuit causal model of depression in humans
A dual-circuit causal model of depression in humans Open
Therapeutic brain stimulation targets are typically designed to treat specific psychiatric or neurological symptoms.1–4 This approach presents a dilemma when treating patients with comorbidities, atypical symptom profiles, or overlapping s…