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View article: Combined angiogenic and hypertrophic gene therapy enhances skeletal muscle growth
Combined angiogenic and hypertrophic gene therapy enhances skeletal muscle growth Open
We used intramuscular and systemic adeno-associated viral vector (AAV) gene delivery of myostatin propeptide (Pro-MSTN) and vascular endothelial growth factor B (VEGF-B) to induce muscle growth and angiogenesis in skeletal muscle. The intr…
View article: NAD+ repletion with niacin counteracts cancer cachexia
NAD+ repletion with niacin counteracts cancer cachexia Open
View article: NAD<sup>+</sup>repletion with niacin counteracts cancer cachexia
NAD<sup>+</sup>repletion with niacin counteracts cancer cachexia Open
SUMMARY Cachexia is a debilitating wasting syndrome and highly prevalent comorbidity in cancer patients. It manifests especially with energy and mitochondrial metabolism aberrations that promote tissue wasting. We recently identified nicot…