Kiarash Behrouzfar
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View article: Smart Nonuniformity for Calibrating Sequencing Depth of a Targeted Gene Panel to Simultaneously Detect Somatic and Germline Variants
Smart Nonuniformity for Calibrating Sequencing Depth of a Targeted Gene Panel to Simultaneously Detect Somatic and Germline Variants Open
Targeted gene panel sequencing that measures genomic variation at different depths has potential diagnostic application. A targeted gene panel, smart nonuniformity sequencing, was developed to detect somatic variants associated with clonal…
View article: mirrorCheck: an R package facilitating informed use of DESeq2’s lfcShrink() function for differential gene expression analysis of clinical samples
mirrorCheck: an R package facilitating informed use of DESeq2’s lfcShrink() function for differential gene expression analysis of clinical samples Open
Motivation The sophisticated lfcShrink() function implemented in the DESeq2 package for differential gene expression analysis aims to reduce noise from low read count and/or highly variable genes in bulk RNA-sequencing data, thus circumven…
View article: Saliva-derived DNA is suitable for the detection of clonal haematopoiesis of indeterminate potential
Saliva-derived DNA is suitable for the detection of clonal haematopoiesis of indeterminate potential Open
Clonal haematopoiesis of indeterminate potential (CHIP) has been associated with many adverse health outcomes. However, further research is required to understand the critical genes and pathways relevant to CHIP subtypes, evaluate how CHIP…
View article: The MexTAg collaborative cross: host genetics affects asbestos related disease latency, but has little influence once tumours develop
The MexTAg collaborative cross: host genetics affects asbestos related disease latency, but has little influence once tumours develop Open
Objectives: This study combines two innovative mouse models in a major gene discovery project to assess the influence of host genetics on asbestos related disease (ARD). Conventional genetics studies provided evidence that some susceptibil…
View article: How to Better Understand the Influence of Host Genetics on Developing an Effective Immune Response to Thoracic Cancers
How to Better Understand the Influence of Host Genetics on Developing an Effective Immune Response to Thoracic Cancers Open
Thoracic cancers pose a significant global health burden. Immune checkpoint blockade therapies have improved treatment outcomes, but durable responses remain limited. Understanding how the host immune system interacts with a developing tum…
View article: The Activity of Sirtuin 1 in MCF-7 Breast Cancer Cell Line: The Effects of Visfatin
The Activity of Sirtuin 1 in MCF-7 Breast Cancer Cell Line: The Effects of Visfatin Open
Background & Objectives: Breast cancer is the most common cancer and the second leading cause of cancer deaths among women. Obesity, hormones, and growth factors are the risk factors for this kind of cancer. One of the changes observed in …