Kicki Ryman
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View article: The early transcriptional and post-transcriptional responses to fluconazole in sensitive and resistant Candida albicans
The early transcriptional and post-transcriptional responses to fluconazole in sensitive and resistant Candida albicans Open
Candida albicans is a leading cause of fungal infections in immunocompromised patients. Management of candidemia relies on a few antifungal agents, with fluconazole being first line therapy. The emergence of fluconazole-resistant strains h…
View article: Proline catabolism is a key factor facilitating Candida albicans pathogenicity
Proline catabolism is a key factor facilitating Candida albicans pathogenicity Open
Candida albicans , the primary etiology of human mycoses, is well-adapted to catabolize proline to obtain energy to initiate morphological switching (yeast to hyphal) and for growth. We report that put1-/- and put2-/- strains, carrying def…
View article: Proline catabolism is key to facilitating <i>Candida albicans</i> pathogenicity
Proline catabolism is key to facilitating <i>Candida albicans</i> pathogenicity Open
Candida albicans , the primary etiology of human mycoses, is well-adapted to catabolize proline to obtain energy to initiate morphological switching (yeast to hyphal) and for growth. We report that put1-/- and put2-/ - strains, carrying de…
View article: Correction: Glutamate dehydrogenase (Gdh2)-dependent alkalization is dispensable for escape from macrophages and virulence of Candida albicans
Correction: Glutamate dehydrogenase (Gdh2)-dependent alkalization is dispensable for escape from macrophages and virulence of Candida albicans Open
[This corrects the article DOI: 10.1371/journal.ppat.1008328.].
View article: Glutamate dehydrogenase (Gdh2)-dependent alkalization is dispensable for escape from macrophages and virulence of Candida albicans
Glutamate dehydrogenase (Gdh2)-dependent alkalization is dispensable for escape from macrophages and virulence of Candida albicans Open
Candida albicans cells depend on the energy derived from amino acid catabolism to induce and sustain hyphal growth inside phagosomes of engulfing macrophages. The concomitant deamination of amino acids is thought to neutralize the acidic m…
View article: Glutamate dehydrogenase (Gdh2)-dependent alkalization is dispensable for escape from macrophages and virulence of<i>Candida albicans</i>
Glutamate dehydrogenase (Gdh2)-dependent alkalization is dispensable for escape from macrophages and virulence of<i>Candida albicans</i> Open
Candida albicans cells depend on the energy derived from amino acid catabolism to induce and sustain hyphal growth inside phagosomes of engulfing macrophages. The concomitant deamination of amino acids is thought to neutralize the acidic m…
View article: Mitochondrial proline catabolism activates Ras1/cAMP/PKA-induced filamentation in Candida albicans
Mitochondrial proline catabolism activates Ras1/cAMP/PKA-induced filamentation in Candida albicans Open
Amino acids are among the earliest identified inducers of yeast-to-hyphal transitions in Candida albicans, an opportunistic fungal pathogen of humans. Here, we show that the morphogenic amino acids arginine, ornithine and proline are inter…
View article: Intersection of phosphate transport, oxidative stress and TOR signalling in Candida albicans virulence
Intersection of phosphate transport, oxidative stress and TOR signalling in Candida albicans virulence Open
Phosphate is an essential macronutrient required for cell growth and division. Pho84 is the major high-affinity cell-surface phosphate importer of Saccharomyces cerevisiae and a crucial element in the phosphate homeostatic system of this m…
View article: Mitochondrial proline catabolism activates Ras1/cAMP/PKA-induced filamentation in<i>Candida albicans</i>
Mitochondrial proline catabolism activates Ras1/cAMP/PKA-induced filamentation in<i>Candida albicans</i> Open
Amino acids are among the earliest identified inducers of yeast-to-hyphal transitions in Candida albicans , an opportunistic fungal pathogen of humans. Here, we show that the morphogenic amino acids arginine, ornithine and proline are inte…