Explanipedia

Open-lung ventilation versus no ventilation during cardiopulmonary bypass in an innovative animal model of heart transplantation Open

Varun A. Karnik, Sebastiano Maria Colombo, Leah Rickards, Silver Heinsar, Louise E. See Hoe , et al. · 2024

Open-lung ventilation during cardiopulmonary bypass (CPB) in patients undergoing heart transplantation (HTx) is a potential strategy to mitigate postoperative acute respiratory distress syndrome (ARDS). We utilized an ovine HTx model to in…

An appraisal of lung computer tomography in very early anti-inflammatory treatment of two different ovine ARDS phenotypes Open

Karin Wildi, Sebastiano Maria Colombo, Daniel McGuire, Carmen Ainola, Silver Heinsar , et al. · 2024

Mortality and morbidity of Acute Respiratory Distress Syndrome (ARDS) are largely unaltered. A possible new approach to treatment of ARDS is offered by the discovery of inflammatory subphenotypes. In an ovine model of ARDS phenotypes, matc…

A Novel Speckle-Tracking Echocardiographic Parameter Assessing Left Ventricular Loading During VA ECMO in a Pre-clinical Model of Cardiogenic Shock Open

Kei Sato, Silver Heinsar, Nchafatso G. Obonyo, Karin Wildi, Kui Liu , et al. · 2023

Donor heart ischemic time can be extended beyond 9 hours using hypothermic machine perfusion in sheep Open

Louise E. See Hoe, Gianluigi Li Bassi, Karin Wildi, Margaret R. Passmore, Mahé Bouquet , et al. · 2023

Overall, compared to current clinical SCS, recipient outcomes following transplantation are not adversely impacted by extending HMP to 8 hours. These results have important implications for clinical transplantation where longer ischemic ti…

Effect of flow change on brain injury during an experimental model of differential hypoxaemia in cardiogenic shock supported by extracorporeal membrane oxygenation Open

Sacha Rozencwajg, Silver Heinsar, Karin Wildi, Jae Seung Jung, Sebastiano Maria Colombo , et al. · 2023

Validation of Messenger Ribonucleic Acid Markers Differentiating Among Human Acute Respiratory Distress Syndrome Subgroups in an Ovine Model of Acute Respiratory Distress Syndrome Phenotypes Open

Karin Wildi, Kieran Hyslop, Jonathan Millar, Samantha Livingstone, Margaret R. Passmore , et al. · 2022

Background The discovery of biological subphenotypes in acute respiratory distress syndrome (ARDS) might offer a new approach to ARDS in general and possibly targeted treatment, but little is known about the underlying biology yet. To vali…

Hypothermic Ex Vivo Perfusion of Donor Hearts can Safely Preserve Post‐transplant Cardiac Function in Sheep for 8 Hours Open

Louise E. See Hoe, Mahé Bouquet, Kieran Hyslop, Margaret R. Passmore, Matthew A. Wells , et al. · 2022

Introduction Heart transplantation (HTx) is the primary therapy for end‐stage heart failure. For HTx, donor hearts are typically preserved on ice in a cooler (devoid of oxygen), termed cold static storage (CSS). CSS beyond 4 hrs increases …

Brain stem death induces pro-inflammatory cytokine production and cardiac dysfunction in sheep model Open

Kafa Walweel, Adrianus C. M. Boon, Louise E. See Hoe, Nchafatso G. Obonyo, Sanne Engkilde Pedersen , et al. · 2021

Characterizing preclinical sub‐phenotypic models of acute respiratory distress syndrome: An experimental ovine study Open

Jonathan Millar, Karin Wildi, Nicole Bartnikowski, Mahé Bouquet, Kieran Hyslop , et al. · 2021

The acute respiratory distress syndrome (ARDS) describes a heterogenous population of patients with acute severe respiratory failure. However, contemporary advances have begun to identify distinct sub‐phenotypes that exist within its broad…

Validation of an Ovine Model of Biological ARDS Subphenotypes by Reproducing mRNA Expression Profiles Open

K. Wildi, Kieran Hyslop, S. Livingstone, C. Ainola, S. Heinsar , et al. · 2021

Compromised right ventricular contractility in an ovine model of heart transplantation following 24 h donor brain stem death Open

Matthew A. Wells, Louise E. See Hoe, Peter Molenaar, Sanne Pedersen, Nchafatso G. Obonyo , et al. · 2021

Donor Heart Preservation by Hypothermic Ex Vivo Perfusion - Improved Recipient Survival and Successful Prolongation of Ischemic Time Open

Louise E. See Hoe, Karin Wildi, K. Skeggs, Mahé Bouquet, Kei Sato , et al. · 2021

Characterising pre-clinical sub-phenotypic models of Acute Respiratory Distress Syndrome: an experimental ovine study Open

Jonathan Millar, Karin Wildi, Nicole Bartnikowski, Mahé Bouquet, Kieran Hyslop , et al. · 2020

The Acute Respiratory Distress Syndrome (ARDS) describes a heterogenous population of patients with acute severe respiratory failure. However, contemporary advances have begun to identify distinct sub-phenotypes that exist within its broad…

Endothelin receptor antagonist improves donor lung function in an ex vivo perfusion system Open

Kafa Walweel, K. Skeggs, Adrianus C. M. Boon, Louise E. See Hoe, Mahé Bouquet , et al. · 2020

Metabolic and Mitochondrial Alterations Following Brain Death and Heart Transplantation Open

Louise E. See Hoe, Matthew A. Wells, Mahé Bouquet, Kieran Hyslop, Margaret R. Passmore , et al. · 2020

(-)-Noradrenaline sensitivity, contractility and mitochondrial function in an ovine model of brain stem death and transplantation Open

Matthew A. Wells, Peter Molenaar, Louise E. See Hoe, Nchafatso G. Obonyo, Lynette M. James , et al. · 2020

120 Hypothermic Ex Vivo Perfusion of Brain Dead Donor Hearts Improves Survival, Systemic Inflammation and Cardiac Function Following Heart Transplantation Open

Louise E. See Hoe, David C. McGiffin, Karin Wildi, Nchafatso G. Obonyo, Mahé Bouquet , et al. · 2020

121 Hypothermic Ex Vivo Perfusion Preserves Post-Transplant Donor Cardiac Function Open

Kei Sato, Louise E. See Hoe, Nchafatso G. Obonyo, Karin Wildi, Sebastiano Maria Colombo , et al. · 2020

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