Kierstin L. Davis
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View article: Immunoregulatory effect of metformin in monocytes exposed to SARS-CoV-2 spike protein subunit 1
Immunoregulatory effect of metformin in monocytes exposed to SARS-CoV-2 spike protein subunit 1 Open
Background Severe COVID-19 is characterized by a hyperinflammatory state associated with an exacerbated inflammatory activation of monocytes and macrophages in the respiratory tract. Metformin has been identified as a potent monocyte infla…
View article: Effect Of Apple Peel Extract Supplementation In Skeletal Muscle Of Aged Mice
Effect Of Apple Peel Extract Supplementation In Skeletal Muscle Of Aged Mice Open
Apple peels contain naturally occurring bioactive compounds called triterpenoids that process properties that can enhance muscle mass and function. Triterpenoids exhibit a wide range of biological functions including antioxidant, anti-micr…
View article: Modulatory Effects of Mdivi-1 on OxLDL-Induced Metabolic Alterations, Inflammatory Responses, and Foam Cell Formation in Human Monocytes
Modulatory Effects of Mdivi-1 on OxLDL-Induced Metabolic Alterations, Inflammatory Responses, and Foam Cell Formation in Human Monocytes Open
Atherosclerosis, a major contributor to cardiovascular disease, involves lipid accumulation and inflammatory processes in arterial walls, with oxidized low-density lipoprotein (OxLDL) playing a central role. OxLDL is increased during aging…
View article: Blueberry intake elevates post-exercise anti-inflammatory oxylipins: a randomized trial
Blueberry intake elevates post-exercise anti-inflammatory oxylipins: a randomized trial Open
View article: Blueberry Intake Elevates Post-Exercise Anti- inflammatory Oxylipins: A Randomized Trial
Blueberry Intake Elevates Post-Exercise Anti- inflammatory Oxylipins: A Randomized Trial Open
This study determined if 18 days of supplementation with blueberries (BL) compared to placebo (PL) could mitigate muscle soreness and damage and improve inflammation resolution in untrained adults (n = 49, ages 30–65 y) after engaging in a…
View article: Astaxanthin supplementation counters exercise-induced decreases in immune-related plasma proteins
Astaxanthin supplementation counters exercise-induced decreases in immune-related plasma proteins Open
Objectives Astaxanthin is a dark red keto-carotenoid found in aquatic animals such as salmon and shrimp, and algae (Haematococcus pluvialis). Astaxanthin has a unique molecular structure that may facilitate anti-oxidative, immunomodulatory…
View article: Metformin Suppresses Monocyte Immunometabolic Activation by SARS-CoV-2 Spike Protein Subunit 1
Metformin Suppresses Monocyte Immunometabolic Activation by SARS-CoV-2 Spike Protein Subunit 1 Open
A hallmark of COVID-19 is a hyperinflammatory state associated with severity. Monocytes undergo metabolic reprogramming and produce inflammatory cytokines when stimulated with SARS-CoV-2. We hypothesized that binding by the viral spike pro…
View article: Metformin Suppresses Monocyte Immunometabolic Activation by SARS-CoV-2 and Spike Protein Subunit 1
Metformin Suppresses Monocyte Immunometabolic Activation by SARS-CoV-2 and Spike Protein Subunit 1 Open
A hallmark of COVID-19 is a hyperinflammatory state that is associated with severity. Various anti-inflammatory therapeutics have shown mixed efficacy in treating COVID-19, and the mechanisms by which hyperinflammation occurs are not well …