Christine Nguyen
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View article: scRepertoire 2: Enhanced and efficient toolkit for single-cell immune profiling
scRepertoire 2: Enhanced and efficient toolkit for single-cell immune profiling Open
Single-cell adaptive immune receptor repertoire sequencing (scAIRR-seq) and single-cell RNA sequencing (scRNA-seq) provide a transformative approach to profiling immune responses at unprecedented resolution across diverse pathophysiologic …
View article: May the SSRIs play a role in the onset of peri- and post-menopausal cervical cancer?
May the SSRIs play a role in the onset of peri- and post-menopausal cervical cancer? Open
The emergence of cancer-causing bacteria and viruses that have become resistant to either antibiotics or viral treatment is often attributed to their overuse in people and livestock. Intriguingly, the class of antidepressant drugs, such as…
View article: The Long Covid-19 Syndrome the Spike Protein and Stem Cells, the Underrated Role of Retrotransposons, a Working Hypothesis
The Long Covid-19 Syndrome the Spike Protein and Stem Cells, the Underrated Role of Retrotransposons, a Working Hypothesis Open
Coronavirus disease-2019 (COVID-19) was seen as a respiratory disease, however, an increasing number of reports indicated that the spike protein could also be the cause of the long-term post-infectious conditions known as Long-COVID charac…
View article: Adaptation of the Tumor Antigen Presentation Machinery to Ionizing Radiation
Adaptation of the Tumor Antigen Presentation Machinery to Ionizing Radiation Open
Ionizing radiation (IR) can reprogram proteasome structure and function in cells and tissues. In this article, we show that IR can promote immunoproteasome synthesis with important implications for Ag processing and presentation and tumor …
View article: Using the Delphi Method to Establish a Novel and Universal System for Classifying Indications behind Delayed Abdominal Closure
Using the Delphi Method to Establish a Novel and Universal System for Classifying Indications behind Delayed Abdominal Closure Open
Introduction: Delayed fascial closure is a common lifesaving feature of damage control laparotomy but may result in serious complications.Accordingly, it should only be applied when required; however, a paucity of guidelines and framework …
View article: The Importance of Arterial Blood Gas Analysis as a Systemic Diagnosis Approach in Assessing and Preventing Chronic Diseases, From Emergency Medicine to the Daily Practice
The Importance of Arterial Blood Gas Analysis as a Systemic Diagnosis Approach in Assessing and Preventing Chronic Diseases, From Emergency Medicine to the Daily Practice Open
Blood gas analysis is a diagnostic tool to evaluate the partial pressures of gas in blood and acid-base content. The use of blood gas analysis enables to clear understanding the respiratory, circulatory, and metabolic disorders. The arteri…
View article: The Anti-Viral Activity of Stem Cells: A Rational Explanation for their Usein Clinical Application
The Anti-Viral Activity of Stem Cells: A Rational Explanation for their Usein Clinical Application Open
It is well established the importance of stem cells (SCs) in tissue growth, regeneration and repair, given their ability to self-renew and differentiate into mature cells. Stem cells are present in all individuals and are potentially activ…
View article: Analysis of Gene Single Nucleotide Polymorphisms in COVID-19 Disease Highlighting the Susceptibility and the Severity towards the Infection
Analysis of Gene Single Nucleotide Polymorphisms in COVID-19 Disease Highlighting the Susceptibility and the Severity towards the Infection Open
Many factors may influence the risk of being infected by SARS-CoV-2, the coronavirus responsible for coronavirus disease 2019 (COVID-19). Exposure to the virus cannot explain the variety of an individual’s responses to the virus and the hi…
View article: The Sub-Molecular and Atomic Theory of Cancer Beginning: The Role of Mitochondria
The Sub-Molecular and Atomic Theory of Cancer Beginning: The Role of Mitochondria Open
Life as we know it is made of strict interaction of atom, metabolism, and genetics, made around the chemistry of the most common elements of the universe: hydrogen, oxygen, nitrogen, sulfur, phosphorus, and carbon. The interaction of atomi…
View article: Characteristics of Hepatitis B Virus Genotype and Sub-Genotype in Hepatocellular Cancer Patients in Vietnam
Characteristics of Hepatitis B Virus Genotype and Sub-Genotype in Hepatocellular Cancer Patients in Vietnam Open
Untreated chronic hepatitis B virus (HBV) infection can lead to chronic liver disease and may progress to cirrhosis or hepatocellular carcinoma (HCC). HBV infection has been prevalent in Vietnam, but there is little information available o…
View article: New Translational Trends in Personalized Medicine: Autologous Peripheral Blood Stem Cells and Plasma for COVID-19 Patient
New Translational Trends in Personalized Medicine: Autologous Peripheral Blood Stem Cells and Plasma for COVID-19 Patient Open
The COVID-19 pandemic, caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), still remains a severe threat. At the time of writing this paper, the second infectious wave has caused more than 280,000 deaths all over the wo…
View article: Immunity Profiling of COVID-19 Infection, Dynamic Variations of Lymphocyte Subsets, a Comparative Analysis on Four Different Groups
Immunity Profiling of COVID-19 Infection, Dynamic Variations of Lymphocyte Subsets, a Comparative Analysis on Four Different Groups Open
Background: A novel coronavirus (SARS-CoV-2)-induced pneumonia (COVID-19) emerged in December 2019 in China, spreading worldwide. The aim of the present investigation was to evaluate the immunological response and the clinical subset of pe…
View article: Sars-CoV-2 Virus Infection May Interfere CD34+ Hematopoietic Stem Cells and Megakaryocyte–Erythroid Progenitors Differentiation Contributing to Platelet Defection towards Insurgence of Thrombocytopenia and Thrombophilia
Sars-CoV-2 Virus Infection May Interfere CD34+ Hematopoietic Stem Cells and Megakaryocyte–Erythroid Progenitors Differentiation Contributing to Platelet Defection towards Insurgence of Thrombocytopenia and Thrombophilia Open
To date, several cases of thrombosis have been confirmed to be related to Sars-CoV-2 infection. Multiple attempts detected the prolonged occurrence of Sars-CoV-2 viral RNA (long COVID) in whole blood suggesting that virus byproducts may re…
View article: Classes of Drugs that Mitigate Radiation Syndromes
Classes of Drugs that Mitigate Radiation Syndromes Open
We previously reported several vignettes on types and classes of drugs able to mitigate acute and, in at least one case, late radiation syndromes in mice. Most of these had emerged from high throughput screening (HTS) of bioactive and chem…
View article: Always track the etiology of thromboembolism in younger adults : brain tumor revealed by recurrent pulmonary embolism in a young man
Always track the etiology of thromboembolism in younger adults : brain tumor revealed by recurrent pulmonary embolism in a young man Open
Pulmonary embolism is a major cause of death worldwide. Recurrences are mainly observed in patients with coagulation disorders or cancers. We describe the case of a brain tumor (Glioblastoma) revealed by behavioral disorder in a young pati…
View article: Mesenchymal Stem Cells: The Secret Children’s Weapons against the SARS-CoV-2 Lethal Infection
Mesenchymal Stem Cells: The Secret Children’s Weapons against the SARS-CoV-2 Lethal Infection Open
Due to the promising effects of mesenchymal stem cells (MSCs) in the treatment of various diseases, this commentary aimed to focus on the auxiliary role of MSCs to reduce inflammatory processes of acute respiratory infections caused by the…
View article: COVID-19 and COVID-like Patients: A Brief Analysis and Findings of Two Deceased Cases
COVID-19 and COVID-like Patients: A Brief Analysis and Findings of Two Deceased Cases Open
BACKGROUND: The predominant pattern of lung lesions in patients affected by coronavirus disease (COVID-19) disease is diffuse alveolar damage with massive thromboembolism similar as described in patients infected with severe acute respirat…
View article: Application of physiologically based pharmacokinetic modeling for sertraline dosing recommendations in pregnancy
Application of physiologically based pharmacokinetic modeling for sertraline dosing recommendations in pregnancy Open
View article: Uncoupling interferon signaling and antigen presentation to overcome immunotherapy resistance due to JAK1 loss in melanoma
Uncoupling interferon signaling and antigen presentation to overcome immunotherapy resistance due to JAK1 loss in melanoma Open
Interferon-independent MHC class I induction restores T cell immunity.
View article: The intraprostatic immune environment after stereotactic body radiotherapy is dominated by myeloid cells
The intraprostatic immune environment after stereotactic body radiotherapy is dominated by myeloid cells Open
View article: Identification of miRNA signatures associated with radiation-induced late lung injury in mice
Identification of miRNA signatures associated with radiation-induced late lung injury in mice Open
Acute radiation exposure of the thorax can lead to late serious, and even life-threatening, pulmonary and cardiac damage. Sporadic in nature, late complications tend to be difficult to predict, which prompted this investigation into identi…
View article: Tumor Size Matters—Understanding Concomitant Tumor Immunity in the Context of Hypofractionated Radiotherapy with Immunotherapy
Tumor Size Matters—Understanding Concomitant Tumor Immunity in the Context of Hypofractionated Radiotherapy with Immunotherapy Open
The purpose of this study was to determine the dynamic contributions of different immune cell subsets to primary and abscopal tumor regression after hypofractionated radiation therapy (hRT) and the impact of anti-PD-1 therapy. A bilateral …
View article: Probiotics in Health and Immunity: A First Step toward Understanding the Importance of Microbiota System in Translational Medicine
Probiotics in Health and Immunity: A First Step toward Understanding the Importance of Microbiota System in Translational Medicine Open
FIGURE 2. Male holotype (IEBR A.2010.36) of Cyrtodactylus pageli sp. n. Phot. Truong Quang Nguyen.
View article: Position of lipidation influences anticancer activity of Smac analogs
Position of lipidation influences anticancer activity of Smac analogs Open
View article: The Aftermath of Surviving Acute Radiation Hematopoietic Syndrome and its Mitigation
The Aftermath of Surviving Acute Radiation Hematopoietic Syndrome and its Mitigation Open
Intensive research is underway to find new agents that can successfully mitigate the acute effects of radiation exposure. This is primarily in response to potential counterthreats of radiological terrorism and nuclear accidents but there i…
View article: 4-(Nitrophenylsulfonyl)piperazines mitigate radiation damage to multiple tissues
4-(Nitrophenylsulfonyl)piperazines mitigate radiation damage to multiple tissues Open
Our ability to use ionizing radiation as an energy source, as a therapeutic agent, and, unfortunately, as a weapon, has evolved tremendously over the past 120 years, yet our tool box to handle the consequences of accidental and unwanted ra…
View article: A perspective on the impact of radiation therapy on the immune rheostat
A perspective on the impact of radiation therapy on the immune rheostat Open
The advent and success of immune checkpoint inhibitors (ICIs) in cancer treatment has broadened the spectrum of tumours that might be considered “immunogenic” and susceptible to immunotherapeutic (IT) intervention. Not all cancer types are…
View article: Evaluation of the Safety of Drugs and Biological Products Used During Lactation: Workshop Summary
Evaluation of the Safety of Drugs and Biological Products Used During Lactation: Workshop Summary Open
This report serves as a summary of a 2‐day public workshop sponsored by the US Food and Drug Administration (FDA) to discuss the safety of drugs and biological products used during lactation. The aim of the workshop was to provide a forum …
View article: Changes in Imaging and Cognition in Juvenile Rats After Whole-Brain Irradiation
Changes in Imaging and Cognition in Juvenile Rats After Whole-Brain Irradiation Open
The developing brains of juvenile rats given clinically relevant fractionated doses of WBI show few abnormalities in the subacute phase but marked late cognitive alterations that may be linked with perturbed MRS signals measured in the cor…