Kihoon Han
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View article: Multicenter, Randomized, Double-Blind, Parallel, Phase 2 Clinical Trial to Compare and Evaluate the Efficacy and Safety of SPC1001 and Monotherapy in Patients With Essential Hypertension
Multicenter, Randomized, Double-Blind, Parallel, Phase 2 Clinical Trial to Compare and Evaluate the Efficacy and Safety of SPC1001 and Monotherapy in Patients With Essential Hypertension Open
ClinicalTrials.gov identifier: NCT06212648.
View article: Seizure evolution in a mouse model of West syndrome involves complex and time-dependent synapse remodeling, gliosis and alterations in lipid metabolism
Seizure evolution in a mouse model of West syndrome involves complex and time-dependent synapse remodeling, gliosis and alterations in lipid metabolism Open
Neurodevelopmental disorders can have long-lasting effects, causing not only early pediatric symptoms but also a range of neurological issues throughout adulthood. West syndrome is a severe neurodevelopmental disorder marked by infantile s…
View article: Longitudinal deep phenotyping in a mouse model of West syndrome reveals temporal dynamics of synapse remodeling, gliosis, and proteomic and lipidomic changes during seizure evolution
Longitudinal deep phenotyping in a mouse model of West syndrome reveals temporal dynamics of synapse remodeling, gliosis, and proteomic and lipidomic changes during seizure evolution Open
Neurodevelopmental disorders can have long-lasting effects, causing not only early pediatric symptoms but also a range of neurological issues throughout adulthood. West syndrome is a severe neurodevelopmental disorder marked by infantile s…
View article: Pharmacological targeting of mitophagy via ALT001 improves herpes simplex virus 1 (HSV1)-mediated microglial inflammation and promotes amyloid β phagocytosis by restricting HSV1 infection
Pharmacological targeting of mitophagy via ALT001 improves herpes simplex virus 1 (HSV1)-mediated microglial inflammation and promotes amyloid β phagocytosis by restricting HSV1 infection Open
Rationale: One of the hallmarks of Alzheimer's disease (AD) is the accumulation of dysfunctional mitochondria. Herpes simplex virus type 1 (HSV1) may be a risk factor for the neuropathology linked to amyloid β (Aβ) accumulation. How…
View article: Quantifying Gait Asymmetry in Stroke Patients: A Statistical Parametric Mapping (SPM) Approach
Quantifying Gait Asymmetry in Stroke Patients: A Statistical Parametric Mapping (SPM) Approach Open
BACKGROUND The VICON Toolkit enables three-dimensional (3D) motion capture for gait analysis. Statistical parametric mapping (SPM) is a voxel-based neuroimaging approach used to identify region-specific effects. This study aimed to apply S…
View article: Shank3 Overexpression Leads to Cardiac Dysfunction in Mice by Disrupting Calcium Homeostasis in Cardiomyocytes
Shank3 Overexpression Leads to Cardiac Dysfunction in Mice by Disrupting Calcium Homeostasis in Cardiomyocytes Open
This study revealed cardiac dysfunction in Shank3-overexpressing transgenic mice, potentially attributed to changes in Ca²⁺ homeostasis and contraction, with a notable reduction in troponin I.
View article: The Impact of Weight-Bearing Lower Limb Exercises on Balance and Gait in Patients Undergoing Total Knee Arthroplasty: Pre-experimental Study
The Impact of Weight-Bearing Lower Limb Exercises on Balance and Gait in Patients Undergoing Total Knee Arthroplasty: Pre-experimental Study Open
View article: An N‐terminal and ankyrin repeat domain interactome of Shank3 identifies the protein complex with the splicing regulator Nono in mice
An N‐terminal and ankyrin repeat domain interactome of Shank3 identifies the protein complex with the splicing regulator Nono in mice Open
An autism‐associated gene Shank3 encodes multiple splicing isoforms, Shank3a‐f. We have recently reported that Shank3a/b‐knockout mice were more susceptible to kainic acid‐induced seizures than wild‐type mice at 4 weeks of age. Little is k…
View article: Cell-autonomous reduction of CYFIP2 changes dendrite length, dendritic protrusion morphology, and inhibitory synapse density in the hippocampal CA1 pyramidal neurons of 17-month-old mice
Cell-autonomous reduction of CYFIP2 changes dendrite length, dendritic protrusion morphology, and inhibitory synapse density in the hippocampal CA1 pyramidal neurons of 17-month-old mice Open
The cytoplasmic FMR1-interacting protein 2 (CYFIP2) have diverse molecular functions in neurons, including the regulation of actin polymerization, mRNA translation, and mitochondrial morphology and function. Mutations in the CYFIP2 …
View article: CYFIP2 P.ARG87CYS CAUSES NEUROLOGICAL DEFECTS AND DEGRADATION OF CYFIP2
CYFIP2 P.ARG87CYS CAUSES NEUROLOGICAL DEFECTS AND DEGRADATION OF CYFIP2 Open
View article: Exploring the Magnetic Properties of Individual Barcode Nanowires using Wide‐Field Diamond Microscopy (Small 40/2023)
Exploring the Magnetic Properties of Individual Barcode Nanowires using Wide‐Field Diamond Microscopy (Small 40/2023) Open
Individual Barcode Nanowires A wide-field quantum microscope based on diamond nitrogen-vacancy centers is used to image the magnetic field from individual barcode magnetic nanowires made of multilayer magnetic structures such as Fe–Au and …
View article: The Triglyceride-Glucose Index is Independently Associated with Chronic Kidney Disease in the Geriatric Population, Regardless of Obesity and Sex
The Triglyceride-Glucose Index is Independently Associated with Chronic Kidney Disease in the Geriatric Population, Regardless of Obesity and Sex Open
Background: Insulin resistance (IR) negatively affects several risk factors of chronic kidney disease (CKD). This cross-sectional study investigated whether the triglyceride-glucose (TyG) index, which reflects IR, was independently associa…
View article: The emerging roles of Shank3 in cardiac function and dysfunction
The emerging roles of Shank3 in cardiac function and dysfunction Open
Shank3 is a member of the Shank family proteins (Shank1–3), which are abundantly present in the postsynaptic density (PSD) of neuronal excitatory synapses. As a core scaffold in the PSD, Shank3 plays a critical role in organizing the macro…
View article: Cell-autonomous reduction of CYFIP2 is insufficient to induce Alzheimer's disease-like pathologies in the hippocampal CA1 pyramidal neurons of aged mice
Cell-autonomous reduction of CYFIP2 is insufficient to induce Alzheimer's disease-like pathologies in the hippocampal CA1 pyramidal neurons of aged mice Open
Cytoplasmic FMR1-interacting protein 2 (CYFIP2) is an evolutionarily conserved multifunctional protein that regulates the neuronal actin cytoskeleton, mRNA translation and transport, and mitochondrial morphology and function. Supporting it…
View article: Exploring the magnetic properties of individual barcode nanowires using wide-field diamond microscopy
Exploring the magnetic properties of individual barcode nanowires using wide-field diamond microscopy Open
Barcode magnetic nanowires typically comprise a multilayer magnetic structure in a single body with more than one segment type. Interestingly, owing to selective functionalization and novel interactions between the layers, barcode magnetic…
View article: A rationally designed optochemogenetic switch for activating canonical Wnt signaling
A rationally designed optochemogenetic switch for activating canonical Wnt signaling Open
Accurate spatiotemporal control of multicellular self-organization by various signaling pathways is essential for developmental stages. In particular, evolutionarily conserved Wnt signaling serves as a major morphogenetic switch to determi…
View article: Neuronal mitochondrial morphology is significantly affected by both fixative and oxygen level during perfusion
Neuronal mitochondrial morphology is significantly affected by both fixative and oxygen level during perfusion Open
Neurons in the brain have a uniquely polarized structure consisting of multiple dendrites and a single axon generated from a cell body. Interestingly, intracellular mitochondria also show strikingly polarized morphologies along the dendrit…
View article: Neuronal mitochondrial morphology is significantly affected by both fixative and oxygen level during perfusion
Neuronal mitochondrial morphology is significantly affected by both fixative and oxygen level during perfusion Open
Neurons in the brain have a uniquely polarized structure consisting of multiple dendrites and a single axon generated from a cell body. Interestingly, intracellular mitochondria also show strikingly polarized morphologies along the dendrit…
View article: Repeated ketamine anesthesia during neurodevelopment upregulates hippocampal activity and enhances drug reward in male mice
Repeated ketamine anesthesia during neurodevelopment upregulates hippocampal activity and enhances drug reward in male mice Open
View article: LAUNCHER: A single-component, light-assisted uncaging switch for endoproteolytic release
LAUNCHER: A single-component, light-assisted uncaging switch for endoproteolytic release Open
Proteases can serve as molecular switches to initiate a wide spectrum of biological events. High efficiency and specificity enhance the potential of proteases as versatile elements in synthetic biological circuits. To address the unmet nee…
View article: Increased ribosomal protein levels and protein synthesis in the striatal synaptosome of Shank3-overexpressing transgenic mice
Increased ribosomal protein levels and protein synthesis in the striatal synaptosome of Shank3-overexpressing transgenic mice Open
View article: The Neomycin Resistance Cassette in the Targeted Allele of Shank3B Knock-Out Mice Has Potential Off-Target Effects to Produce an Unusual Shank3 Isoform
The Neomycin Resistance Cassette in the Targeted Allele of Shank3B Knock-Out Mice Has Potential Off-Target Effects to Produce an Unusual Shank3 Isoform Open
Variants of the SH3 and multiple ankyrin repeat domains 3 ( SHANK3 ), which encodes postsynaptic scaffolds, are associated with brain disorders. The targeted alleles in a few Shank3 knock-out (KO) lines contain a neomycin resistance (Neo) …
View article: Additional file 4 of Increased ribosomal protein levels and protein synthesis in the striatal synaptosome of Shank3-overexpressing transgenic mice
Additional file 4 of Increased ribosomal protein levels and protein synthesis in the striatal synaptosome of Shank3-overexpressing transgenic mice Open
Additional file 4. All raw numerical data for image quantification.
View article: Additional file 2 of Increased ribosomal protein levels and protein synthesis in the striatal synaptosome of Shank3-overexpressing transgenic mice
Additional file 2 of Increased ribosomal protein levels and protein synthesis in the striatal synaptosome of Shank3-overexpressing transgenic mice Open
Additional file 2: Table S1. List of 63 up-regulated proteins in the striatal synaptosome of Shank3 TG mice. Table S2. Summary of RNA-seq mapping results. Table S3. List of proteins identified from the quantitative proteomic analysis in th…
View article: Enhanced Prefrontal Neuronal Activity and Social Dominance Behavior in Postnatal Forebrain Excitatory Neuron-Specific Cyfip2 Knock-Out Mice
Enhanced Prefrontal Neuronal Activity and Social Dominance Behavior in Postnatal Forebrain Excitatory Neuron-Specific Cyfip2 Knock-Out Mice Open
The cytoplasmic fragile X mental retardation 1 (FMR1)-interacting protein 2 (CYFIP2) gene is associated with epilepsy, intellectual disability (ID), and developmental delay, suggesting its critical role in proper neuronal developmen…
View article: Table of Contents
Table of Contents Open
View article: Altered presynaptic function and number of mitochondria in the medial prefrontal cortex of adult Cyfip2 heterozygous mice
Altered presynaptic function and number of mitochondria in the medial prefrontal cortex of adult Cyfip2 heterozygous mice Open
View article: Coexpression enrichment analysis at the single-cell level reveals convergent defects in neural progenitor cells and their cell-type transitions in neurodevelopmental disorders
Coexpression enrichment analysis at the single-cell level reveals convergent defects in neural progenitor cells and their cell-type transitions in neurodevelopmental disorders Open
A large number of genes have been implicated in neurodevelopmental disorders (NDDs), but their contributions to NDD pathology are difficult to decipher without understanding their diverse roles in different brain cell types. Here, we integ…
View article: Co-expression enrichment analysis at the single-cell level reveals convergent defects in neural progenitor cells and their cell-type transitions in neurodevelopmental disorders
Co-expression enrichment analysis at the single-cell level reveals convergent defects in neural progenitor cells and their cell-type transitions in neurodevelopmental disorders Open
Recent large-scale sequencing studies have identified a great number of genes whose disruptions cause neurodevelopmental disorders (NDDs). However, cell-type-specific functions of NDD genes and their contributions to NDD pathology are uncl…
View article: Editorial: Shankopathies: Shank Protein Deficiency-Induced Synaptic Diseases
Editorial: Shankopathies: Shank Protein Deficiency-Induced Synaptic Diseases Open
The results leading to this publication have received funding from the Innovative Medicines Initiative 2 Joint Undertaking under grant agreement No 777394 for the project AIMS-2-TRIALS. This Joint Undertaking receives support from the Euro…