Killian Donovan
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View article: Effects of Empagliflozin on Urine Biomarkers in EMPA-KIDNEY
Effects of Empagliflozin on Urine Biomarkers in EMPA-KIDNEY Open
SGLT2 inhibition imparts a large and sustained reduction in urine UMOD, and also increases some biomarkers partially reabsorbed by proximal tubules, without consistently affecting markers of tubular injury. These effects deserve further de…
View article: An application of the MR-Horse method to reduce selection bias in genome-wide association studies of disease progression
An application of the MR-Horse method to reduce selection bias in genome-wide association studies of disease progression Open
Genome-wide association studies (GWAS) of disease progression are vulnerable to collider bias caused by selection of participants with disease at study entry. This bias introduces spurious associations between disease progression and genet…
View article: An application of the MR-Horse method to reduce selection bias in genome-wide association studies of disease progression
An application of the MR-Horse method to reduce selection bias in genome-wide association studies of disease progression Open
Genome-wide association studies (GWAS) of disease progression are vulnerable to collider bias caused by selection of participants with disease at study entry. This bias introduces spurious associations between disease progression and genet…
View article: Fibroblast Growth Factor-23 and Risk of Cardiovascular Diseases
Fibroblast Growth Factor-23 and Risk of Cardiovascular Diseases Open
Background Fibroblast growth factor-23 (FGF-23) is associated with a range of cardiovascular and noncardiovascular diseases in conventional epidemiological studies, but substantial residual confounding may exist. Mendelian randomization ap…
View article: Fibroblast Growth Factor-23 and Risk of Cardiovascular Diseases: a Mendelian Randomisation study
Fibroblast Growth Factor-23 and Risk of Cardiovascular Diseases: a Mendelian Randomisation study Open
Fibroblast growth factor 23 (FGF-23) is associated with a range of cardiovascular and non-cardiovascular diseases in conventional epidemiological studies, but substantial residual confounding may exist. Mendelian randomisation approaches c…
View article: Risk of Infection Associated With Administration of Intravenous Iron
Risk of Infection Associated With Administration of Intravenous Iron Open
Importance Intravenous iron is recommended by many clinical guidelines based largely on its effectiveness in reducing anemia. However, the association with important safety outcomes, such as infection, remains uncertain. Objective To exami…
View article: Stored blood has compromised oxygen unloading kinetics that can be normalized with rejuvenation and predicted from corpuscular side-scatter
Stored blood has compromised oxygen unloading kinetics that can be normalized with rejuvenation and predicted from corpuscular side-scatter Open
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View article: Classification of intestinal <scp>T</scp>‐cell receptor repertoires using machine learning methods can identify patients with coeliac disease regardless of dietary gluten status
Classification of intestinal <span>T</span>‐cell receptor repertoires using machine learning methods can identify patients with coeliac disease regardless of dietary gluten status Open
In coeliac disease (CeD), immune‐mediated small intestinal damage is precipitated by gluten, leading to variable symptoms and complications, occasionally including aggressive T‐cell lymphoma. Diagnosis, based primarily on histopathological…
View article: Single‐cell oxygen saturation imaging shows that gas exchange by red blood cells is not impaired in COVID‐19 patients
Single‐cell oxygen saturation imaging shows that gas exchange by red blood cells is not impaired in COVID‐19 patients Open
SARS-CoV-2 coronavirus infection is characterised by a marked inflammatory state and viral pneumonitis. A striking clinical feature is severe hypoxaemia, often in the presence of near-normal lung mechanics. Several hypotheses have been put…
View article: Systemic hypoferremia and severity of hypoxemic respiratory failure in COVID-19
Systemic hypoferremia and severity of hypoxemic respiratory failure in COVID-19 Open
Dear Editor,Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory coronavirus 2 (SARS-CoV-2) was declared a pandemic on March 11, 2020 [1].Risk factors associated with respiratory failure in patients with COVID-19 include …
View article: Systemic hypoferraemia and severity of hypoxaemic respiratory failure in COVID-19
Systemic hypoferraemia and severity of hypoxaemic respiratory failure in COVID-19 Open
Coronavirus disease 2019 (COVID-19) mortality is associated with hypoxaemia, multiorgan failure, and thromboinflammation. However severity of disease varies considerably and understanding physiological changes that may link to poor outcome…
View article: Authors’ Reply
Authors’ Reply Open
The published observational data show similarly sized epidemiologic associations between increased fibroblast growth factor-23 (FGF-23) concentration and risk of a range of cardiovascular (atherosclerotic and nonatherosclerotic) and noncar…
View article: Fibroblast Growth Factor-23 and Risks of Cardiovascular and Noncardiovascular Diseases: A Meta-Analysis
Fibroblast Growth Factor-23 and Risks of Cardiovascular and Noncardiovascular Diseases: A Meta-Analysis Open
Background Fibroblast growth factor-23 (FGF-23) has been hypothesized to play a role in the increased risk of cardiovascular disease in patients with CKD. Methods We identified prospective studies reporting associations between FGF-23 conc…
View article: Response
Response Open
We welcome Nepogodiev and Glasbey's response to our letter. The central thesis of our original piece was that points-based selection criteria for training posts are flawed because they are founded on misleading metrics and do not allow for…