Kim A. Connelly
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View article: FGF-23, hsCRP, Cardiovascular Events, and the Benefit of Canagliflozin in the CANVAS Trial
FGF-23, hsCRP, Cardiovascular Events, and the Benefit of Canagliflozin in the CANVAS Trial Open
FGF-23 and hsCRP are biomarkers associated with increased CV risk, but these markers did not identify participants who preferentially benefited from treatment with canagliflozin.
View article: Lipid Nanoparticle Delivery of Mesenchymal Stromal Cell-Derived microRNA 187-3p as a First-in-Class Therapy for Myocardial Dysfunction in Sepsis
Lipid Nanoparticle Delivery of Mesenchymal Stromal Cell-Derived microRNA 187-3p as a First-in-Class Therapy for Myocardial Dysfunction in Sepsis Open
Background Sepsis-induced myocardial dysfunction is a common and critical complication of sepsis. Extracellular vesicles (EVs) from clonally expanded immortalized mesenchymal stromal cells (ciMSCs) contain microRNAs that may be exploited a…
View article: Left ventricular pressure‐loading improves pressure‐induced right ventricular remodeling by redistributing mechanical load and reducing mechanosignaling
Left ventricular pressure‐loading improves pressure‐induced right ventricular remodeling by redistributing mechanical load and reducing mechanosignaling Open
Right ventricular (RV) function under pressure overload (PO) is critical in congenital heart disease outcomes. While moderate left ventricular (LV) pressure‐loading has been shown to benefit RV function, the mechanisms and optimal degree o…
View article: Machine Learning Reveals How Depression Influences Chest Pain Localisation and Its Predictive Value for Coronary Artery Disease
Machine Learning Reveals How Depression Influences Chest Pain Localisation and Its Predictive Value for Coronary Artery Disease Open
Depression modifies the predictive value of chest pain localisation for CAD. A "depressed chest pain profile" involving nontraditional locations was more strongly associated with CAD in those with depression, and a more central "nondepress…
View article: Sodium zirconium cyclosilicate, hyperkalaemia, and spironolactone optimization in heart failure with reduced ejection fraction: The <scp>REALIZE</scp>‐K open‐label run‐in phase
Sodium zirconium cyclosilicate, hyperkalaemia, and spironolactone optimization in heart failure with reduced ejection fraction: The <span>REALIZE</span>‐K open‐label run‐in phase Open
No abstract available.
View article: Prevalence of Orthostatic Autonomic Dysregulation in Pediatric Concussion
Prevalence of Orthostatic Autonomic Dysregulation in Pediatric Concussion Open
Importance Pediatric concussion can affect the autonomic nervous system. Understanding the prevalence and characteristics of physiological autonomic dysregulation (AD) and symptom provocation following concussion is crucial for optimizing …
View article: The Alternative Imaging Modalities in Ischemic Heart Failure (AIMI-HF) Trial—IMAGE HF Project 1A
The Alternative Imaging Modalities in Ischemic Heart Failure (AIMI-HF) Trial—IMAGE HF Project 1A Open
View article: Practical Implications of Obesity for Cardiovascular Diagnostics
Practical Implications of Obesity for Cardiovascular Diagnostics Open
Obesity, one of the most prevalent and pressing global health challenges, has significant implications for cardiovascular disease (CVD) morbidity and mortality. Diagnostic testing for CVD is substantially affected by obesity, which affects…
View article: The Role of GLP-1R and GIPR Agonism in Heart Failure
The Role of GLP-1R and GIPR Agonism in Heart Failure Open
Heart failure (HF) is a clinical syndrome characterized by signs and symptoms of structural and functional cardiac abnormalities. It is corroborated by elevated N-terminal pro‑B‑type natriuretic peptide (NT-proBNP) levels and objective evi…
View article: Dual inhibition of <scp>TGFβ</scp> and <scp>PDGF</scp> improves <scp>RV</scp> remodeling and function in response to <scp>RV</scp> pressure or volume‐loading
Dual inhibition of <span>TGFβ</span> and <span>PDGF</span> improves <span>RV</span> remodeling and function in response to <span>RV</span> pressure or volume‐loading Open
Right ventricular (RV) pressure and volume loading induce RV fibrosis in association with RV dysfunction, morbidity, and mortality in repaired tetralogy of Fallot. Transforming‐growth factor‐β1 (TGFβ1) and platelet‐derived growth factor (P…
View article: Racial and ethnic variations of electrocardiographic and echocardiographic indices in female athletes: a meta-analysis
Racial and ethnic variations of electrocardiographic and echocardiographic indices in female athletes: a meta-analysis Open
Background Although it is well known that high-intensity physical training can induce structural changes to the heart, most of the published data concern male athletes only. There remains a paucity of knowledge concerning the potential rac…
View article: Induction of proximal tubular proliferation and lengthening in response to sodium glucose linked cotransporter‐2 inhibition in experimental rats
Induction of proximal tubular proliferation and lengthening in response to sodium glucose linked cotransporter‐2 inhibition in experimental rats Open
Aims/Introduction While SGLT2 accounts for >90% of kidney glucose reabsorption, its pharmacological inhibition or genetic knockdown reduces glucose reabsorption by only 50%. Materials and Methods We postulated that the less than expected g…
View article: MOTS-c: Magical Molecule for Diabetic Cardiomyopathy?
MOTS-c: Magical Molecule for Diabetic Cardiomyopathy? Open
View article: Homeostatic Role of Decorin in Right Ventricular Pressure Overload and Pulmonary Hypertension Induced Remodeling
Homeostatic Role of Decorin in Right Ventricular Pressure Overload and Pulmonary Hypertension Induced Remodeling Open
Right ventricular (RV) pressure loading induces RV profibrotic signaling and fibrosis associated with RV dysfunction. RV decorin protein levels are decreased in patients with chronic RV pressure loading. RV decorin protein levels are also …
View article: Serial and regional assessment of the right ventricular molecular and functional response to pressure loading
Serial and regional assessment of the right ventricular molecular and functional response to pressure loading Open
Exploring the dynamics of right ventricular remodeling: unveiling the intricate interplay between inflammation, metabolic shifts, and fibrotic signaling in response to pressure loading. Through a comprehensive study spanning from initiatio…
View article: Empagliflozin and left atrial function in patients with type 2 diabetes mellitus and coronary artery disease: insight from the EMPA-HEART CardioLink‐6 randomized clinical trial
Empagliflozin and left atrial function in patients with type 2 diabetes mellitus and coronary artery disease: insight from the EMPA-HEART CardioLink‐6 randomized clinical trial Open
Background Sodium-glucose cotransporter-2 (SGLT2) inhibitors have demonstrated reduction in heart failure outcomes in patients with type 2 diabetes mellitus, although the exact mechanism of benefit remains unclear. Alteration in left atria…
View article: Mitral regurgitation evolution after transcatheter tricuspid valve interventions—a sub-analysis of the TriValve registry
Mitral regurgitation evolution after transcatheter tricuspid valve interventions—a sub-analysis of the TriValve registry Open
Aims Transcatheter tricuspid valve interventions (TTVI) are increasingly used to treat patients with significant tricuspid regurgitation (TR). The evolution of concurrent mitral regurgitation (MR) severity after TTVI is currently unknown a…
View article: Sodium Zirconium Cyclosilicate in HFrEF and Hyperkalemia
Sodium Zirconium Cyclosilicate in HFrEF and Hyperkalemia Open
REALIZE-K is the first trial to evaluate whether SZC can enable rapid and safe MRA optimization and long-term continuation in patients with HFrEF and prevalent/high risk of hyperkalemia. (Study to Assess Efficacy and Safety of SZC for the …
View article: Endothelial progenitor cells for diabetic cardiac and kidney disease
Endothelial progenitor cells for diabetic cardiac and kidney disease Open
The management of diabetes mellitus and its resultant end organ dysfunction represents a major challenge to global health-care systems. Diabetic cardiac and kidney disease commonly co-occur and are significant contributors to the morbidity…
View article: Salvianolic acid B inhibits thrombosis and directly blocks the thrombin catalytic site
Salvianolic acid B inhibits thrombosis and directly blocks the thrombin catalytic site Open
View article: Exercise‐Dependent Modulation of Immunological Response Pathways in Endurance Athletes With and Without Atrial Fibrillation
Exercise‐Dependent Modulation of Immunological Response Pathways in Endurance Athletes With and Without Atrial Fibrillation Open
Background Atrial fibrillation (AF) is a common arrhythmia characterized by uncoordinated atrial electrical activity. Lone AF occurs in the absence of traditional risk factors and is frequently observed in male endurance athletes, who face…
View article: Atrial fibrillation in middle-aged athletes: Impact on left atrial, ventricular and exercise performance
Atrial fibrillation in middle-aged athletes: Impact on left atrial, ventricular and exercise performance Open
High volume endurance training may increase the risk of paroxysmal atrial fibrillation (AF) in middle-aged athletes. Limited data are available describing the cardiovascular phenotype of middle-aged endurance athletes, or the impact of AF …
View article: Tissue mapping by cardiac magnetic resonance imaging for the prognostication of cardiac amyloidosis: A systematic review and meta-analysis
Tissue mapping by cardiac magnetic resonance imaging for the prognostication of cardiac amyloidosis: A systematic review and meta-analysis Open
Higher native T1 time and ECV, and lower myocardial to skeletal T2 ratio, on CMR are associated with worse mortality in patients with cardiac amyloidosis. Therefore, tissue mapping using CMR may offer a useful non-invasive technique to mon…
View article: The effectiveness of sodium-glucose co-transporter 2 inhibitors on cardiorenal outcomes: an updated systematic review and meta-analysis
The effectiveness of sodium-glucose co-transporter 2 inhibitors on cardiorenal outcomes: an updated systematic review and meta-analysis Open
View article: Sodium Zirconium Cyclosilicate for Management of Hyperkalaemia During Spironolactone Optimisation in Patients with Heart Failure and Reduced Ejection Fraction: The Randomized Withdrawal REALIZE-K Trial
Sodium Zirconium Cyclosilicate for Management of Hyperkalaemia During Spironolactone Optimisation in Patients with Heart Failure and Reduced Ejection Fraction: The Randomized Withdrawal REALIZE-K Trial Open
View article: Objective and Subjective Assessments of Exercise Burden in Masters Athletes Are Poorly Correlated
Objective and Subjective Assessments of Exercise Burden in Masters Athletes Are Poorly Correlated Open
Accurate quantification of exercise volume (burden) is crucial for understanding links between exercise and cardiovascular outcomes in older endurance athletes (EA). Exercise burden, an integral of intensity and duration (MET·min), is typi…
View article: Effect of empagliflozin on cardiac remodelling in South Asian and non-South Asian individuals: insights from the EMPA-HEART CardioLink-6 randomised clinical trial
Effect of empagliflozin on cardiac remodelling in South Asian and non-South Asian individuals: insights from the EMPA-HEART CardioLink-6 randomised clinical trial Open
Background This exploratory sub-analysis of the EMPA-HEART CardioLink-6 trial examined whether the previously reported benefit of the sodium-glucose cotransporter 2 (SGLT2) inhibitor empagliflozin on left ventricular (LV) mass (LVM) regres…
View article: A Systematic Review of Interleukins as Diagnostic and Prognostic Biomarkers for Peripheral Artery Disease
A Systematic Review of Interleukins as Diagnostic and Prognostic Biomarkers for Peripheral Artery Disease Open
Background: Peripheral artery disease (PAD) involves atherosclerosis of the lower extremity arteries and is a major contributor to limb loss and death worldwide. Several studies have demonstrated that interleukins (ILs) play an important r…
View article: Concurrent left ventricular pressure-loading improves right ventricular function, remodeling, and molecular signaling in response to pulmonary artery banding
Concurrent left ventricular pressure-loading improves right ventricular function, remodeling, and molecular signaling in response to pulmonary artery banding Open
Background Studies have established the significance of right ventricle (RV) function in individuals with many congenital heart diseases, however the impact of pressure overload (PO) on the RV, concomitant with changes in LV pressure, has …
View article: Integrin alpha 11 is cardioprotective post myocardial infarction, regulating infarct formation and collagen organization
Integrin alpha 11 is cardioprotective post myocardial infarction, regulating infarct formation and collagen organization Open
Background Post Myocardial Infarction (MI), fibrosis and in particular collagen production is an important response in order to replace apoptotic cells within the injured area and stabilize the heart wall1. Cardiac fibroblasts in and aroun…