Kim Blom
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View article: Longitudinal human CD8+ T-cell fate following yellow fever vaccination 3548
Longitudinal human CD8+ T-cell fate following yellow fever vaccination 3548 Open
Description CD8+ T-cells are critical effectors in the immune response against viral infections and cancers. A long-standing question within T-cell immunology concerns the mechanisms that govern which cells give rise to long lived memory C…
View article: Impact of systemic SARS-CoV-2 vaccination on mucosal IgA responses to subsequent breakthrough infection
Impact of systemic SARS-CoV-2 vaccination on mucosal IgA responses to subsequent breakthrough infection Open
This study was supported by grants from Region Stockholm, and SciLifeLab and the Knut and Alice Wallenberg Foundation, SSMF and European Research Council. We thank the Public Health Agency of Sweden for support.
View article: Qdenga-induced dengue caused by minor DENV-2 subvariant(s) in the vaccine, with two amino acid substitutions in the E protein
Qdenga-induced dengue caused by minor DENV-2 subvariant(s) in the vaccine, with two amino acid substitutions in the E protein Open
Highlight: We describe a Qdenga-induced DENV-2-infection in a Swedish traveller. Comparative sequencing suggests that the vaccine contained a small fraction of identical virus as detected in the patient, suggesting a selection of a DENV-2-…
View article: Dysregulated Adaptive Immune Responses to SARS-CoV-2 in Immunocompromised Individuals
Dysregulated Adaptive Immune Responses to SARS-CoV-2 in Immunocompromised Individuals Open
The SARS-CoV-2 virus poses a significant risk to immunocompromised patients, who display weakened immunity and reduced seroconversion following infection and vaccination. In this study, we recruited 19 hospitalized patients with immune dis…
View article: Antigen-specific T cell responses following single and co-administration of tick-borne encephalitis, Japanese encephalitis, and yellow fever virus vaccines: Results from an open-label, non-randomized clinical trial-cohort
Antigen-specific T cell responses following single and co-administration of tick-borne encephalitis, Japanese encephalitis, and yellow fever virus vaccines: Results from an open-label, non-randomized clinical trial-cohort Open
Background Flavivirus infections pose a significant global health burden, highlighting the need for safe and effective vaccination strategies. Co-administration of different vaccines, including licensed flavivirus vaccines, is commonly pra…
View article: High prevalence of undocumented SARS-CoV-2 infections revealed by analysis of nucleocapsid-specific IgG responses in diagnosed and undiagnosed individuals
High prevalence of undocumented SARS-CoV-2 infections revealed by analysis of nucleocapsid-specific IgG responses in diagnosed and undiagnosed individuals Open
Acute SARS-CoV-2 infections are not always diagnosed; hence an unknown proportion of all infections are not documented. SARS-CoV-2 can induce spike and nucleocapsid protein specific IgG antibodies, which can be detected in seroprevalence s…
View article: Antigen-specific T cell responses following single and co-administration of tick-borne encephalitis, Japanese encephalitis, and yellow fever virus vaccines: Results from an open-label, non-randomized clinical trial-cohort
Antigen-specific T cell responses following single and co-administration of tick-borne encephalitis, Japanese encephalitis, and yellow fever virus vaccines: Results from an open-label, non-randomized clinical trial-cohort Open
Background Flavivirus infections pose a significant global health burden, highlighting the need for safe and effective vaccination strategies. Co-administration of different vaccines, including licensed flavivirus vaccines, is commonly pra…
View article: Logistics for Rapid Isolation of Viruses From Humans
Logistics for Rapid Isolation of Viruses From Humans Open
An important aspect of microbiological surveillance is the ability to access live viruses for microneutralization assays, which enables the study of viral characteristics and mechanisms in vitro and production of positive controls for diag…
View article: Comparison of SARS-CoV-2 spike-specific IgA and IgG in nasal secretions, saliva and serum
Comparison of SARS-CoV-2 spike-specific IgA and IgG in nasal secretions, saliva and serum Open
Introduction Several novel vaccine platforms aim at mucosal immunity in the respiratory tract to block SARS-CoV-2 transmission. Standardized methods for mucosal sample collection and quantification of mucosal antibodies are therefore urgen…
View article: Prevalence of SARS-CoV-2 infections among Swedish healthcare workers on duty in December 2023
Prevalence of SARS-CoV-2 infections among Swedish healthcare workers on duty in December 2023 Open
C 1: Prevalence, viral load, and viral variants among Swedish healthcare workers on duty in December 2023.A) Percentage positive per day during December 4-15, 2023.Bars show total number of tested participants per day; grey = negative; bla…
View article: Clonally heritable gene expression imparts a layer of diversity within cell types
Clonally heritable gene expression imparts a layer of diversity within cell types Open
Cell types can be classified according to shared patterns of transcription. Non-genetic variability among individual cells of the same type has been ascribed to stochastic transcriptional bursting and transient cell states. Using high-cove…
View article: Humoral immune responses to the monovalent XBB.1.5-adapted BNT162b2 mRNA booster
Humoral immune responses to the monovalent XBB.1.5-adapted BNT162b2 mRNA booster Open
Continued SARS-CoV-2 evolution and immune escape necessitated the development of updated vaccines, and a monovalent vaccine incorporating the XBB.1.5 variant spike protein is currently being rolled out. Amidst the emergence of the highly m…
View article: High Prevalence of SARS-CoV-2 Omicron Infection Despite High Seroprevalence, Sweden, 2022
High Prevalence of SARS-CoV-2 Omicron Infection Despite High Seroprevalence, Sweden, 2022 Open
We performed 2 surveys during 2022 to estimate point prevalences of SARS-CoV-2 infection compared with overall seroprevalence in Sweden. Point prevalence was 1.4% in March and 1.5% in September. Estimated seroprevalence was >80%, including…
View article: Mucosal immune responses following a fourth SARS-CoV-2 vaccine dose
Mucosal immune responses following a fourth SARS-CoV-2 vaccine dose Open
Supplementary appendix This appendix formed part of the original submission. We post it as supplied by the authors. Supplement to: Bladh O, Marking U, Havervall S, et al. Mucosal immune responses following a fourth SARS-CoV-2 vaccine dose.…
View article: Vaccine-induced correlate of protection against fatal COVID-19 in the old and frail during waves of neutralization resistant variants of concern
Vaccine-induced correlate of protection against fatal COVID-19 in the old and frail during waves of neutralization resistant variants of concern Open
Background To inform future preventive measures including repeated vaccinations, we have searched for a clinically useful immune correlate of protection against fatal Covid-19 among nursing homes residents. Methods We performed repeated ca…
View article: Safety and immunogenicity following co-administration of Yellow fever vaccine with Tick-borne encephalitis or Japanese encephalitis vaccines: Results from an open label, non-randomized clinical trial
Safety and immunogenicity following co-administration of Yellow fever vaccine with Tick-borne encephalitis or Japanese encephalitis vaccines: Results from an open label, non-randomized clinical trial Open
Background Flavivirus infections pose a significant global health burden underscoring the need for the development of safe and effective vaccination strategies. Available flavivirus vaccines are from time to time concomitantly delivered to…
View article: Anti-Spike Mucosal IgA Protection against SARS-CoV-2 Omicron Infection
Anti-Spike Mucosal IgA Protection against SARS-CoV-2 Omicron Infection Open
nated, 0 to 13 days, 14 to 27 days, 1 to 2 months, 3 to 4 months, 5 to 6 months, 7 to 8 months, or ≥9 months).Among the patients who had received two doses of vaccine, waning of effectiveness against hospitalization was evident as early as…
View article: Infection Rate of SARS-CoV-2 in Asymptomatic Healthcare Workers, Sweden, June 2022
Infection Rate of SARS-CoV-2 in Asymptomatic Healthcare Workers, Sweden, June 2022 Open
Given the recent surge in SARS-CoV-2 Omicron infections, we performed a quantitative PCR screening survey during June 28-29, 2022, in Stockholm, Sweden, to investigate SARS-CoV-2 point prevalence in a group with high exposure risk. Results…
View article: Safety and immunogenicity following co-administration of Yellow fever vaccine with Tick-borne encephalitis or Japanese encephalitis vaccines: Results from an open label, non-randomized clinical trial
Safety and immunogenicity following co-administration of Yellow fever vaccine with Tick-borne encephalitis or Japanese encephalitis vaccines: Results from an open label, non-randomized clinical trial Open
Background Flavivirus infections pose a significant global health burden underscoring the need for the development of safe and efficient vaccination strategies. Available flavivirus vaccines are from time to time concomitantly delivered to…