Kim E. Kortekaas
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View article: Predicting lymph node metastases in three different vulvar squamous cell carcinoma subgroups
Predicting lymph node metastases in three different vulvar squamous cell carcinoma subgroups Open
HPVneg/p53abn VSCCs have a higher risk of LNM compared to HPVpos VSCCs. HPVneg/p53wt VSCC are considered an intermediate risk group. Molecular subgroups contribute to LNM risk assessment at diagnosis. We developed a well-performing, clinic…
View article: Decreased risk-proneness with increasing age in equally raised and kept wolves and dogs
Decreased risk-proneness with increasing age in equally raised and kept wolves and dogs Open
A basic mechanism of domestication is the selection for fearlessness and acceptance of humans as social partners, which may affect risk-taking behavior and the ability to use humans as social support, both at the behavioural and physiologi…
View article: 63 Infiltration by myeloid cells is an independent prognostic biomarker in vulvar squamous cell carcinoma, associated to stem cell-like features of the tumor
63 Infiltration by myeloid cells is an independent prognostic biomarker in vulvar squamous cell carcinoma, associated to stem cell-like features of the tumor Open
Background Vulvar squamous cell carcinoma (VSCC) is an aggressive and highly mutilating disease. It arises through the malignant transformation of healthy vulvar tissue to invasive carcinoma, via an HPV infection or a P53 or other mutation…
View article: Supplementary Data from CD39 Identifies the CD4<sup>+</sup> Tumor-Specific T-cell Population in Human Cancer
Supplementary Data from CD39 Identifies the CD4<sup>+</sup> Tumor-Specific T-cell Population in Human Cancer Open
Supplementary data
View article: Supplementary Data from CD39 Identifies the CD4<sup>+</sup> Tumor-Specific T-cell Population in Human Cancer
Supplementary Data from CD39 Identifies the CD4<sup>+</sup> Tumor-Specific T-cell Population in Human Cancer Open
Supplementary data
View article: Data from CD39 Identifies the CD4<sup>+</sup> Tumor-Specific T-cell Population in Human Cancer
Data from CD39 Identifies the CD4<sup>+</sup> Tumor-Specific T-cell Population in Human Cancer Open
The accumulation of tumor-specific CD4+ and CD8+ effector T cells is key to an effective antitumor response. Locally, CD4+ T cells promote the recruitment and effector function of tumor-specific CD8+ T cells and activate innate killer cell…
View article: Data from CD39 Identifies the CD4<sup>+</sup> Tumor-Specific T-cell Population in Human Cancer
Data from CD39 Identifies the CD4<sup>+</sup> Tumor-Specific T-cell Population in Human Cancer Open
The accumulation of tumor-specific CD4+ and CD8+ effector T cells is key to an effective antitumor response. Locally, CD4+ T cells promote the recruitment and effector function of tumor-specific CD8+ T cells and activate innate killer cell…
View article: Figure S1 to S5 from The Anatomical Location Shapes the Immune Infiltrate in Tumors of Same Etiology and Affects Survival
Figure S1 to S5 from The Anatomical Location Shapes the Immune Infiltrate in Tumors of Same Etiology and Affects Survival Open
Supplemental figures
View article: Table S1 to S3 from The Anatomical Location Shapes the Immune Infiltrate in Tumors of Same Etiology and Affects Survival
Table S1 to S3 from The Anatomical Location Shapes the Immune Infiltrate in Tumors of Same Etiology and Affects Survival Open
Supplemental tables
View article: Data from The Anatomical Location Shapes the Immune Infiltrate in Tumors of Same Etiology and Affects Survival
Data from The Anatomical Location Shapes the Immune Infiltrate in Tumors of Same Etiology and Affects Survival Open
Purpose:The tumor immune microenvironment determines clinical outcome. Whether the original tissue in which a primary tumor develops influences this microenvironment is not well understood.Experimental Design:We applied high-dimensional si…
View article: Data from The Anatomical Location Shapes the Immune Infiltrate in Tumors of Same Etiology and Affects Survival
Data from The Anatomical Location Shapes the Immune Infiltrate in Tumors of Same Etiology and Affects Survival Open
Purpose:The tumor immune microenvironment determines clinical outcome. Whether the original tissue in which a primary tumor develops influences this microenvironment is not well understood.Experimental Design:We applied high-dimensional si…
View article: Figure S1 to S5 from The Anatomical Location Shapes the Immune Infiltrate in Tumors of Same Etiology and Affects Survival
Figure S1 to S5 from The Anatomical Location Shapes the Immune Infiltrate in Tumors of Same Etiology and Affects Survival Open
Supplemental figures
View article: Table S1 to S3 from The Anatomical Location Shapes the Immune Infiltrate in Tumors of Same Etiology and Affects Survival
Table S1 to S3 from The Anatomical Location Shapes the Immune Infiltrate in Tumors of Same Etiology and Affects Survival Open
Supplemental tables
View article: Primary vulvar squamous cell carcinomas with high T cell infiltration and active immune signaling are potential candidates for neoadjuvant PD-1/PD-L1 immunotherapy
Primary vulvar squamous cell carcinomas with high T cell infiltration and active immune signaling are potential candidates for neoadjuvant PD-1/PD-L1 immunotherapy Open
Background A profound insight into the immune landscape of vulvar squamous cell carcinoma (VSCC) is lacking. Here, an in-depth interrogation of T cell infiltration, local immune contexture, signaling pathways and checkpoint molecule expres…
View article: Social Context Influences Resting Physiology in Dogs
Social Context Influences Resting Physiology in Dogs Open
Domestication has affected the social life of dogs. They seem to be less dependent on their pack members than wolves, potentially causing dogs to be more alert towards their environment, especially when resting. Such a response has been fo…
View article: Context-Specific Arousal During Resting in Wolves and Dogs: Effects of Domestication?
Context-Specific Arousal During Resting in Wolves and Dogs: Effects of Domestication? Open
Due to domestication, dogs differ from wolves in the way they respond to their environment, including to humans. Selection for tameness and the associated changes to the autonomic nervous system (ANS) regulation have been proposed as the p…
View article: Performance of the pattern‐based interpretation of p53 immunohistochemistry as a surrogate for <i>TP53</i> mutations in vulvar squamous cell carcinoma
Performance of the pattern‐based interpretation of p53 immunohistochemistry as a surrogate for <i>TP53</i> mutations in vulvar squamous cell carcinoma Open
Aims The most commonly mutated gene in vulvar squamous cell carcinoma (VSCC) is TP53 and its prognostic value, particularly in HPV‐independent VSCC, is uncertain. In other tumours, p53 immunohistochemistry (IHC) is an excellent surrogate m…
View article: High numbers of activated helper T cells are associated with better clinical outcome in early stage vulvar cancer, irrespective of HPV or p53 status
High numbers of activated helper T cells are associated with better clinical outcome in early stage vulvar cancer, irrespective of HPV or p53 status Open
This is the first study demonstrating an association between intraepithelial T cells and clinical outcome in VSCC. Our data suggest that abnormal p53 expressing VSCCs mostly are cold tumors whereas HPV-driven VSCCs are strongly T-cell infi…
View article: Practical Guidance for Measuring and Reporting Surgical Margins in Vulvar Cancer
Practical Guidance for Measuring and Reporting Surgical Margins in Vulvar Cancer Open
Surgical resection with free surgical margins is the cornerstone of successful primary treatment of vulvar squamous cell carcinoma (VSCC). In general reexcision is recommended when the minimum peripheral surgical margin (MPSM) is <8 mm mic…
View article: Does socio-ecology drive differences in alertness between wolves and dogs when resting?
Does socio-ecology drive differences in alertness between wolves and dogs when resting? Open
Variation in resting behaviour across animals may be driven by adaptations towards their environment. Wolves and dogs seem promising models to examine this idea as they share a common ancestor, but occupy different socio-ecological niches.…
View article: Hydrothorax, ascites and an abdominal mass: not always signs of a malignancy - Three cases of Meigs' syndrome
Hydrothorax, ascites and an abdominal mass: not always signs of a malignancy - Three cases of Meigs' syndrome Open
This case report presents three cases of Meigs' syndrome: a benign ovarian tumor with ascites and a hydrothorax. After removal of the ovarian tumor, the symptoms resolved and the patients became asymptomatic. In daily practice, Meigs' synd…
View article: Non-surgical intervention for retroperitoneal lymphogenic and pulmonary metastases of a benign leiomyoma: treatment with ulipristal acetate
Non-surgical intervention for retroperitoneal lymphogenic and pulmonary metastases of a benign leiomyoma: treatment with ulipristal acetate Open
This case report describes a very rare coexistence of retroperitoneal lymphogenic and pulmonary metastases of a benign leiomyoma: benign metastasising leiomyoma (BML). Despite surgical treatment growth of multiple nodules in the lungs, ome…