Keith A.A. Fox
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View article: Blood pressure lowering in isolated diastolic hypertension and cardiovascular risk: an individual patient data meta-analysis
Blood pressure lowering in isolated diastolic hypertension and cardiovascular risk: an individual patient data meta-analysis Open
Background and Aims Blood pressure (BP) lowering reduces cardiovascular disease (CVD) risk; however, the benefits of treating patients with normal systolic BP but elevated diastolic BP remain uncertain. Methods Data from 51 randomized cont…
View article: Focused Ultrasound (FUS) and Pediatric Brain Tumors: Current Status and Future Directions
Focused Ultrasound (FUS) and Pediatric Brain Tumors: Current Status and Future Directions Open
Diffuse intrinsic pontine glioma (DIPG), or as it is newly redefined, diffuse midline glioma (DMG), remains one of the most horrific diagnoses in pediatric oncology. Aggressive and inaccessible to standard treatments, it is generally consi…
View article: Extension of the GRACE score for non-ST-elevation acute coronary syndrome: a development and validation study in ten countries
Extension of the GRACE score for non-ST-elevation acute coronary syndrome: a development and validation study in ten countries Open
Swiss Heart Foundation, University of Zurich Foundation, Kurt and Senta Herrmann Foundation, Theodor and Ida Herzog-Egli Foundation, and Foundation for Cardiovascular Research-Zurich Heart House.
View article: Regional left ventricular wall stress postmyocardial infarction with magnetic resonance imaging in swine
Regional left ventricular wall stress postmyocardial infarction with magnetic resonance imaging in swine Open
This study introduces a novel approach to assess regional left ventricular wall stress using cardiac MRI in a clinically relevant model of myocardial infarction. We demonstrate that postinfarction remodeling leads to increased wall stress …
View article: Smoking trajectories and residual cardiovascular risk in patients with stable coronary artery disease: an international cohort study
Smoking trajectories and residual cardiovascular risk in patients with stable coronary artery disease: an international cohort study Open
Aims There is a variety of smoking habits trajectories in patients with established stable coronary artery disease (CAD), with unclear consequences on cardiovascular (CV) events. We aimed to clarify the impact of smoking cessation and redu…
View article: Symptoms of Autonomic Nervous System Dysregulation and Diabetes Distress in Adults with Type 1 and Type 2 Diabetes
Symptoms of Autonomic Nervous System Dysregulation and Diabetes Distress in Adults with Type 1 and Type 2 Diabetes Open
Objective: To test the association of autonomic nervous system (ANS) dysregulation symptoms and diabetes distress (DD) in adults with type 1 (T1D; Study 1) and type 2 diabetes (T2D: Study 2)Research Design and Methods: 556 T1D adults and 2…
View article: P-1022. Ventricular Shunt Failure in Patients with Coccidioidal Meningitis in Central California, A Single Center Experience
P-1022. Ventricular Shunt Failure in Patients with Coccidioidal Meningitis in Central California, A Single Center Experience Open
Background Coccidioidal meningitis (CM) represents the most deleterious form of disseminated coccidioidomycosis and warrants lifelong antifungal therapy. Communicating hydrocephalus is a well-known complication of CM. Antifungal therapy an…
View article: Dual Pathway Inhibition in Patients with Atherosclerosis with or without Heart Failure: Insights from the XATOA Registry
Dual Pathway Inhibition in Patients with Atherosclerosis with or without Heart Failure: Insights from the XATOA Registry Open
In a generalizable cohort of patients with atherosclerotic disease and HF, the use of DPI therapy is associated with outcomes similar to those observed in recent randomized controlled clinical trials.
View article: Effectiveness of the GRACE risk score according to troponin elevation in patients admitted with non-ST elevation acute coronary syndrome: a post hoc analysis of the UKGRIS parallel group cluster randomised controlled trial
Effectiveness of the GRACE risk score according to troponin elevation in patients admitted with non-ST elevation acute coronary syndrome: a post hoc analysis of the UKGRIS parallel group cluster randomised controlled trial Open
Background The effectiveness of risk stratification using the Global Registry of Acute Coronary Events (GRACE) Risk Score (GRS) for patients presenting to hospital with suspected non-ST elevation acute coronary syndrome (NSTEACS) according…
View article: Type 2 myocardial infarction: challenges in diagnosis and treatment
Type 2 myocardial infarction: challenges in diagnosis and treatment Open
The Fourth Universal Definition of Myocardial Infarction recommends a classification based on aetiology, in recognition that the underlying pathophysiology of myocardial infarction influences the approach to investigation and treatment. Ty…
View article: Association of care specialty with anticoagulant prescription and clinical outcomes in newly diagnosed atrial fibrillation: Results from the GARFIELD-AF registry
Association of care specialty with anticoagulant prescription and clinical outcomes in newly diagnosed atrial fibrillation: Results from the GARFIELD-AF registry Open
gov. Unique identifier for GARFIELD-AF: NCT01090362.
View article: RETROGRADE THORACIC DUCT ACCESS FOR EMBOLIZATION OF LYMPHATIC MALFORMATIONS IN A CHILD WITH CONGENITAL HEART DISEASE AND A PLEXIFORM THORACIC DUCT VARIANT
RETROGRADE THORACIC DUCT ACCESS FOR EMBOLIZATION OF LYMPHATIC MALFORMATIONS IN A CHILD WITH CONGENITAL HEART DISEASE AND A PLEXIFORM THORACIC DUCT VARIANT Open
The physiologic sequelae of the atypical vasculature in patients with congenital heart disease can result in potentially fatal lymphatic complications, especially after corrective cardiac surgery. Transcatheter embolization of the thoracic…
View article: Impact of patient selection in clinical trials: application of ROCKET AF and ARISTOTLE criteria in GARFIELD-AF
Impact of patient selection in clinical trials: application of ROCKET AF and ARISTOTLE criteria in GARFIELD-AF Open
Background The extent to which differences in results from Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation (ARISTOTLE) and Rivaroxaban Once Daily Oral Direct Factor Xa Inhibition Compared with Vitami…
View article: Incidence and predictors of major gastrointestinal bleeding in patients on aspirin, low‐dose rivaroxaban, or the combination: Secondary analysis of the <scp>COMPASS</scp> randomised controlled trial
Incidence and predictors of major gastrointestinal bleeding in patients on aspirin, low‐dose rivaroxaban, or the combination: Secondary analysis of the <span>COMPASS</span> randomised controlled trial Open
Summary Background The incidence of major gastrointestinal bleeding (GIB) in patients on low‐dose direct‐acting oral anticoagulants (DOACs) is relatively unknown. Estimates from randomised controlled trials (RCTs) are lacking. Aims To asse…
View article: Assessment of Days Alive Out of Hospital as a Possible End Point in Trials of Stroke Prevention for Atrial Fibrillation: A ROCKET AF Analysis
Assessment of Days Alive Out of Hospital as a Possible End Point in Trials of Stroke Prevention for Atrial Fibrillation: A ROCKET AF Analysis Open
Background Days alive out of hospital (DAOH) is an objective and patient‐centered net benefit end point. There are no assessments of DAOH in clinical trials of interventions for atrial fibrillation (AF), and it is not known whether this en…
View article: The Net Clinical Outcome of Dual-Pathway Inhibition in Clinical Practice: The “Xarelto plus Acetylsalicylic Acid: Treatment Patterns and Outcomes in Patients with Atherosclerosis” Registry
The Net Clinical Outcome of Dual-Pathway Inhibition in Clinical Practice: The “Xarelto plus Acetylsalicylic Acid: Treatment Patterns and Outcomes in Patients with Atherosclerosis” Registry Open
Background: In the COMPASS trial, the combination of acetylsalicylic acid (ASA) plus 2.5 mg rivaroxaban twice daily (dual-pathway inhibition, DPI) has been shown to be superior to ASA monotherapy for the reduction in ischemic major adverse…
View article: Invasive vs. conservative management of older patients with non-ST-elevation acute coronary syndrome: individual patient data meta-analysis
Invasive vs. conservative management of older patients with non-ST-elevation acute coronary syndrome: individual patient data meta-analysis Open
Background and Aims Older patients with non-ST-elevation acute coronary syndrome (NSTEACS) are less likely to receive guideline-recommended care including coronary angiography and revascularization. Evidence-based recommendations regarding…
View article: Identifying the highest risk vascular patients: Insights from the XATOA registry
Identifying the highest risk vascular patients: Insights from the XATOA registry Open
Patients with polyvascular disease represent a substantial subset of patients in clinical practice and should be prioritized to receive maximal medical therapy including low dose rivaroxaban (2.5 mg BID) and aspirin.
View article: Country and health expenditure are major predictors of withholding anticoagulation in atrial fibrillation patients at high risk of stroke
Country and health expenditure are major predictors of withholding anticoagulation in atrial fibrillation patients at high risk of stroke Open
Background Guidelines for patients with atrial fibrillation (AF) at high thromboembolic risk recommend oral anticoagulants (OACs) for preventing stroke and systemic embolism (SE). The reasons for guideline non-adherence are still unclear. …
View article: Biologically derived epicardial patch induces macrophage mediated pathophysiologic repair in chronically infarcted swine hearts
Biologically derived epicardial patch induces macrophage mediated pathophysiologic repair in chronically infarcted swine hearts Open
There are nearly 65 million people with chronic heart failure (CHF) globally, with no treatment directed at the pathologic cause of the disease, the loss of functioning cardiomyocytes. We have an allogeneic cardiac patch comprised of cardi…
View article: Relationship between care speciality and atrial fibrillation outcomes in the GARFIELD-AF registry
Relationship between care speciality and atrial fibrillation outcomes in the GARFIELD-AF registry Open
Background Atrial fibrillation (AF) is associated with cardio-embolic stroke. It remains unclear whether AF outcomes are related to the care speciality at AF diagnosis. Purpose To explore associations between the care speciality at AF diag…
View article: Validation of the GRACE 3.0 score and redefinition of the risk threshold for early invasive treatment in non-ST-segment elevation acute coronary syndromes: a modelling study from five countries
Validation of the GRACE 3.0 score and redefinition of the risk threshold for early invasive treatment in non-ST-segment elevation acute coronary syndromes: a modelling study from five countries Open
Background Clinical use of the GRACE scoring system is recommended across international guidelines to guide early treatment stratification in patients with non-ST-segment elevation acute coronary syndromes (NSTE-ACS). Recently, the machine…
View article: Patients with AF and dementia are undertreated for their AF and cardiovascular comorbidities: results from the GARFIELD-AF registry
Patients with AF and dementia are undertreated for their AF and cardiovascular comorbidities: results from the GARFIELD-AF registry Open
Background Oral anticoagulation (OAC) is key in preventing stroke in patients with atrial fibrillation (AF). However, patients with AF and dementia pose practical therapeutic challenges, such as compliance and haemorrhagic complications, r…
View article: Towards personalized cardiovascular care: Global Registry of Acute Coronary Events 3.0 score heralds artificial intelligence era
Towards personalized cardiovascular care: Global Registry of Acute Coronary Events 3.0 score heralds artificial intelligence era Open
Figure 1 Machine learning-based risk assessment for personalized care of patients with
View article: Predictors of intracranial hemorrhage in patients with atrial fibrillation treated with oral anticoagulants: Insights from the GARFIELD‐AF and ORBIT‐AF registries
Predictors of intracranial hemorrhage in patients with atrial fibrillation treated with oral anticoagulants: Insights from the GARFIELD‐AF and ORBIT‐AF registries Open
Background An unmet need exists to reliably predict the risk of intracranial hemorrhage (ICH) in patients with atrial fibrillation (AF) treated with oral anticoagulants (OACs). Hypothesis An externally validated model improves ICH risk str…
View article: Oral anticoagulation across diabetic subtypes in patients with newly diagnosed atrial fibrillation: A report from the <scp>GARFIELD‐AF</scp> registry
Oral anticoagulation across diabetic subtypes in patients with newly diagnosed atrial fibrillation: A report from the <span>GARFIELD‐AF</span> registry Open
Aims This study aims to describe both management and prognosis of patients with diabetes mellitus (DM) and newly diagnosed atrial fibrillation (AF), overall as well as by antidiabetic treatment, and to assess the influence of oral anticoag…