Kim Serdons
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View article: cGMP-compliant high-yield automated production of [18F]AlF-FAPI-74: optimization of quality control and evaluation of molar dose impact
cGMP-compliant high-yield automated production of [18F]AlF-FAPI-74: optimization of quality control and evaluation of molar dose impact Open
A robust, fully automated, and GMP-compliant production process for [18F]AlF-FAPI-74 is reported with high yield, purity, and stability, suitable for centralized production and distribution. The improved radio-HPLC method enhances quality …
View article: <sup>18</sup>F-AlF-NOTA-Octreotide Outperforms<sup>68</sup>Ga-DOTATATE/NOC PET in Neuroendocrine Tumor Patients: Results from a Prospective, Multicenter Study
<sup>18</sup>F-AlF-NOTA-Octreotide Outperforms<sup>68</sup>Ga-DOTATATE/NOC PET in Neuroendocrine Tumor Patients: Results from a Prospective, Multicenter Study Open
18F-labeled somatostatin analogs (SSAs) could represent a valid alternative to the current gold standard, 68Ga-labeled SSAs, for somatostatin receptor imaging in patients with neuroendocrine tumors (NETs), given their logistic advantages. …
The PET tracer [ <sup>11</sup> C]MK-6884 quantifies M4 muscarinic receptor in rhesus monkeys and patients with Alzheimer’s disease Open
[ 11 C]MK-6884 is an M4R-specific PET tracer for quantifying target engagement in brain and providing insights into AD neuropathology.
View article: Lack of association between bridging integrator 1 ( <i>BIN1</i> ) rs744373 polymorphism and tau‐PET load in cognitively intact older adults
Lack of association between bridging integrator 1 ( <i>BIN1</i> ) rs744373 polymorphism and tau‐PET load in cognitively intact older adults Open
Introduction The bridging integrator 1( BIN1) rs744373 risk polymorphism has been linked to increased [ 18 F]AV1451 signal in non‐demented older adults (ie., mild cognitive impairment [MCI] plus cognitively normal [CN] individuals). Howeve…
View article: Translation of HDAC6 PET Imaging Using [<sup>18</sup>F]EKZ-001–cGMP Production and Measurement of HDAC6 Target Occupancy in Nonhuman Primates
Translation of HDAC6 PET Imaging Using [<sup>18</sup>F]EKZ-001–cGMP Production and Measurement of HDAC6 Target Occupancy in Nonhuman Primates Open
Histone deacetylase 6 (HDAC6) is a multifunctional cytoplasmic enzyme involved in diverse cellular processes such as intracellular transport and protein quality control. Inhibition of HDAC6 can alleviate defects in cell and rodent models o…
View article: Automated GMP compliant production of [18F]AlF-NOTA-octreotide
Automated GMP compliant production of [18F]AlF-NOTA-octreotide Open
Background Gallium-68 labeled synthetic somatostatin analogs for PET/CT imaging are the current gold standard for somatostatin receptor imaging in neuroendocrine tumor patients. Despite good imaging properties, their use in clinical practi…
View article: IC‐P‐150: [C‐11]MK‐6884 PET: CHARACTERIZING BRAIN M4 RECEPTORS IN HEALTHY ELDERLY VOLUNTEERS AND ACETYLCHOLINESTERASE INHIBITORS‐TREATED AD PATIENTS
IC‐P‐150: [C‐11]MK‐6884 PET: CHARACTERIZING BRAIN M4 RECEPTORS IN HEALTHY ELDERLY VOLUNTEERS AND ACETYLCHOLINESTERASE INHIBITORS‐TREATED AD PATIENTS Open
The M4 muscarinic cholinergic receptor may play important roles in the pathophysiology and treatment of Alzheimer's disease (AD). This study aimed to assess the utility of [11C]MK-6884, a novel PET radiotracer targeting the M4 allosteric m…
P2‐350: POSTMORTEM BINDING STUDY OF [<sup>18</sup>F]‐AV1451 AND [<sup>18</sup>F]‐THK5351 IN SEMANTIC VARIANT PRIMARY PROGRESSIVE APHASIA Open
[18F]THK5351 as well as [18F]AV1451 tau-PET consistently shows high anterior temporal lobe retention in primary progressive aphasia semantic variant (PPA SV). This syndrome is however most commonly associated with TDP-43 type C proteinopat…
O5‐07‐02: APOLIPOPROTEIN E AND BIN1 POLYMORPHISMS DIFFERENTIALLY AFFECT CORTICAL AMYLOID AND TAU LOAD IN HEALTHY OLDER ADULTS Open
Genome-wide association studies have revealed multiple risk polymorphisms for Alzheimer's disease (AD). Some, like APOE, are well-known to be associated with the amyloidogenic pathway according to numerous amyloid PET studies. Others, like…
<sup>18</sup>F-JNJ-64413739, a Novel PET Ligand for the P2X7 Ion Channel: Radiation Dosimetry, Kinetic Modeling, Test-Retest Variability, and Occupancy of the P2X7 Antagonist JNJ-54175446 Open
The P2X7 receptor (P2X7R) is an adenosine triphosphate-gated ion channel that is predominantly expressed on microglial cells in the central nervous system. We report the clinical qualification of P2X7-specific PET ligand 18F-JNJ-64413739 i…
View article: Brain Imaging of Alzheimer Dementia Patients and Elderly Controls with <sup>18</sup>F-MK-6240, a PET Tracer Targeting Neurofibrillary Tangles
Brain Imaging of Alzheimer Dementia Patients and Elderly Controls with <sup>18</sup>F-MK-6240, a PET Tracer Targeting Neurofibrillary Tangles Open
18F-MK-6240 (18F-labeled 6-(fluoro)-3-(1H-pyrrolo[2,3-c]pyridin-1-yl)isoquinolin-5-amine) is a highly selective, subnanomolar-affinity PET tracer for imaging neurofibrillary tangles (NFTs). Plasma kinetics, brain uptake, and preliminary qu…
View article: [P3–381]: FIRST EVALUATION OF THE NEUROFIBRILLARY TANGLES RADIOLIGAND [<sup>18</sup>F]MK‐6240 IN ALZHEIMER's DISEASE PATIENTS
[P3–381]: FIRST EVALUATION OF THE NEUROFIBRILLARY TANGLES RADIOLIGAND [<sup>18</sup>F]MK‐6240 IN ALZHEIMER's DISEASE PATIENTS Open
Dementia correlates strongly with the extent of neurofibrillary tangles (NFT). We recently disclosed [18F]MK-6240, a potent and selective NFT radioligand designed to be more specific and sensitive than previously known NFT PET radioligands…
View article: [IC‐P‐177]: FIRST EVALUATION OF THE NEUROFIBRILLARY TANGLES RADIOLIGAND [<sup>18</sup>F]MK‐6240 IN ALZHEIMER's DISEASE PATIENTS
[IC‐P‐177]: FIRST EVALUATION OF THE NEUROFIBRILLARY TANGLES RADIOLIGAND [<sup>18</sup>F]MK‐6240 IN ALZHEIMER's DISEASE PATIENTS Open
Dementia correlates strongly with the extent of neurofibrillary tangles (NFT). We recently disclosed [18F]MK-6240, a potent and selective NFT radioligand designed to be more specific and sensitive than previously known NFT PET radioligands…