Kimberle C. Chapin
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View article: Combination of a Rapid Diagnostic Assay and Antimicrobial Stewardship Intervention for Gram-Negative Bacteremia
Combination of a Rapid Diagnostic Assay and Antimicrobial Stewardship Intervention for Gram-Negative Bacteremia Open
Background Traditional blood cultures for gram-negative bacteremia can take up to 72 hours or more to return results, prolonging the duration of empiric broad-spectrum intravenous antibiotics. The Accelerate Pheno system provides rapid ide…
View article: Etiologies of bloody diarrhea in children presenting with acute gastroenteritis to US emergency departments
Etiologies of bloody diarrhea in children presenting with acute gastroenteritis to US emergency departments Open
Among 111 children presenting with bloody diarrhea in a multicenter study of molecular testing in US emergency departments, we found viral pathogens in 18%, bacteria in 48%, protozoa in 2%, and no pathogens detected in 38%.
View article: Guide to Utilization of the Microbiology Laboratory for Diagnosis of Infectious Diseases: 2024 Update by the Infectious Diseases Society of America (IDSA) and the American Society for Microbiology (ASM)
Guide to Utilization of the Microbiology Laboratory for Diagnosis of Infectious Diseases: 2024 Update by the Infectious Diseases Society of America (IDSA) and the American Society for Microbiology (ASM) Open
The critical nature of the microbiology laboratory in infectious disease diagnosis calls for a close, positive working relationship between the physician and the microbiologists who provide enormous value to the healthcare team. This docum…
View article: Clinical Impact of Multiplex Molecular Diagnostic Testing in Children with Acute Gastroenteritis Presenting to An Emergency Department: A Multicenter Prospective Study
Clinical Impact of Multiplex Molecular Diagnostic Testing in Children with Acute Gastroenteritis Presenting to An Emergency Department: A Multicenter Prospective Study Open
Background Multiplex molecular diagnostic panels have greatly enhanced detection of gastrointestinal pathogens. However, data on the impact of these tests on clinical and patient-centered outcomes are limited. Methods We conducted a prospe…
View article: 531. Clinical Evaluation of the BioFire® FilmArray® Gastrointestinal (GI) Panel for use with Rectal Swab Specimens in Cary-Blair Media
531. Clinical Evaluation of the BioFire® FilmArray® Gastrointestinal (GI) Panel for use with Rectal Swab Specimens in Cary-Blair Media Open
Background The BioFire® FilmArray® Gastrointestinal (GI) Panel provides results for 22 bacterial, viral, and protozoan pathogens responsible for GI infection in about an hour. This test is indicated for use with stool specimens in Cary-Bla…
View article: A Closer Look at the Laboratory Impact of Utilizing ePlex Blood Culture Identification Panels: a Workflow Analysis Using Rapid Molecular Detection for Positive Blood Cultures
A Closer Look at the Laboratory Impact of Utilizing ePlex Blood Culture Identification Panels: a Workflow Analysis Using Rapid Molecular Detection for Positive Blood Cultures Open
Sepsis is a leading cause of morbidity and mortality worldwide. Rapid identification of the causative agent is of critical importance for the prompt initiation of the appropriate antibiotic treatment.
View article: At-Home Testing for Infectious Diseases: The Laboratory Where You Live
At-Home Testing for Infectious Diseases: The Laboratory Where You Live Open
View article: A multicenter evaluation of viral bloodstream detections in children presenting to the Emergency Department with suspected systemic infection
A multicenter evaluation of viral bloodstream detections in children presenting to the Emergency Department with suspected systemic infection Open
View article: RETRACTED: Heterogeneous Longitudinal Antibody Responses to Covid-19 mRNA Vaccination
RETRACTED: Heterogeneous Longitudinal Antibody Responses to Covid-19 mRNA Vaccination Open
Host responses to SARS-CoV-2-Spike mRNA vaccines vary in magnitude, duration and occurrence. This study raises concern about the lack of vaccine protection in as many as 8% of otherwise normal people, and the need for open dialog about fut…
View article: 668. Rapid Identification and Antimicrobial Susceptibility Testing of Gram-Negative Rod Bacteremia: Impact on Duration of Hospital Admission
668. Rapid Identification and Antimicrobial Susceptibility Testing of Gram-Negative Rod Bacteremia: Impact on Duration of Hospital Admission Open
Background There are many emerging diagnostic technologies that provide rapid identification (ID) and antimicrobial susceptibility testing (AST) of blood cultures after initial microbial growth is detected. The clinical utility of having t…
View article: 285. Evaluation of the ePlex® Blood Culture Identification (BCID) Panels for Gram-positive/Gram-negative bacteria and yeasts
285. Evaluation of the ePlex® Blood Culture Identification (BCID) Panels for Gram-positive/Gram-negative bacteria and yeasts Open
Background Multiple methods used for blood culture identification create inconsistent to reporting of critical results. Study aim was to evaluate performance characteristics of the ePlex BCID panels compared to current standard of care (SO…
View article: A Retrospective Review of Antibiotic Usage in Patients with Hypoxic Respiratory Failure with a Positive Rapid Pathogen Panel (RPP) Test
A Retrospective Review of Antibiotic Usage in Patients with Hypoxic Respiratory Failure with a Positive Rapid Pathogen Panel (RPP) Test Open
View article: Opportunities Revealed for Antimicrobial Stewardship and Clinical Practice with Implementation of a Rapid Respiratory Multiplex Assay
Opportunities Revealed for Antimicrobial Stewardship and Clinical Practice with Implementation of a Rapid Respiratory Multiplex Assay Open
Few studies assess the utility of rapid multiplex molecular respiratory panels in adult patients. Previous multiplex PCR assays took hours to days from order time to result. We analyze the clinical impact of switching to a molecular assay …
View article: Reduced Time to Positive <i>Cutibacterium acnes</i> Culture Utilizing a Novel Incubation Technique: A Retrospective Cohort Study
Reduced Time to Positive <i>Cutibacterium acnes</i> Culture Utilizing a Novel Incubation Technique: A Retrospective Cohort Study Open
Introduction Cutibacterium acnes ( C. acnes) is a common pathogen in postoperative shoulder infections. The purpose of this study was to evaluate the time to positive cultures for C. acnes and compare our experience before and after implem…
View article: 2084. Prospective, Multi-Center Analysis of a BioFire® FilmArray® Childhood Systemic Infection (CSI) Panel for Detection of Viral Bloodstream Infections in a Pediatric Emergency Department Setting
2084. Prospective, Multi-Center Analysis of a BioFire® FilmArray® Childhood Systemic Infection (CSI) Panel for Detection of Viral Bloodstream Infections in a Pediatric Emergency Department Setting Open
BACKGROUND: Early determination of viral etiology among febrile children with suspicion of systemic infection by use of rapid molecular assay could impact patient care. BioFire(®) FilmArray(®) Childhood Systemic Infection (CSI) Panel is a …
View article: Cystic neutrophilic granulomatous mastitis with corynebacterium and staphylococcus mimicking breast carcinoma
Cystic neutrophilic granulomatous mastitis with corynebacterium and staphylococcus mimicking breast carcinoma Open
Key Clinical Message Cystic neutrophilic granulomatous mastitis (CNGM) is an increasingly recognized entity in the differential diagnosis of granulomatous inflammation involving the breast. We present the first case report of CNGM mimickin…
View article: A Guide to Utilization of the Microbiology Laboratory for Diagnosis of Infectious Diseases: 2018 Update by the Infectious Diseases Society of America and the American Society for Microbiologya
A Guide to Utilization of the Microbiology Laboratory for Diagnosis of Infectious Diseases: 2018 Update by the Infectious Diseases Society of America and the American Society for Microbiologya Open
The critical nature of the microbiology laboratory in infectious disease diagnosis calls for a close, positive working relationship between the physician/advanced practice provider and the microbiologists who provide enormous value to the …
View article: FilmArray® Gastrointestinal (GI) Panel for Viral Acute Gastroenteritis Detection in Pediatric Patients
FilmArray® Gastrointestinal (GI) Panel for Viral Acute Gastroenteritis Detection in Pediatric Patients Open
Acute viral gastroenteritis is one of the leading causes of diarrheal diseases. The FilmArray GI Panel is a PCR based assay that detects 22 different enteric pathogens including five viruses (Adenovirus F 40/41, Astrovirus, Norovirus GI/GI…
View article: Clinical Predictors of Shigella and Campylobacter Infection in Children in the United States
Clinical Predictors of Shigella and Campylobacter Infection in Children in the United States Open
Background Infectious gastroenteritis is a major cause of morbidity and mortality among children worldwide. While most episodes are self-limiting, for select pathogens such as Shigella and Campylobacter, etiological diagnosis may allow eff…
View article: The Spectrum of Pediatric Osteoarticular Infections: A Comparative Study
The Spectrum of Pediatric Osteoarticular Infections: A Comparative Study Open
Background There is a paucity of data relating to pediatric subacute or chronic hematogenous osteomyelitis (SCHO), non-hematogenous osteoarticular infections (NHO), and osteoarticular hardware infections (HI). A comparative analysis of the…
View article: Multicenter Evaluation of BioFire FilmArray Meningitis/Encephalitis Panel for Detection of Bacteria, Viruses, and Yeast in Cerebrospinal Fluid Specimens
Multicenter Evaluation of BioFire FilmArray Meningitis/Encephalitis Panel for Detection of Bacteria, Viruses, and Yeast in Cerebrospinal Fluid Specimens Open
Rapid diagnosis and treatment of infectious meningitis and encephalitis are critical to minimize morbidity and mortality. Comprehensive testing of cerebrospinal fluid (CSF) often includes Gram stain, culture, antigen detection, and molecul…
View article: Implementation of a Molecular Diagnostic Test for Pediatric Acute Gastroenteritis: The FilmArray Gastrointestinal Panel IMPACT Study
Implementation of a Molecular Diagnostic Test for Pediatric Acute Gastroenteritis: The FilmArray Gastrointestinal Panel IMPACT Study Open
View article: Prevalence of Neisseria gonorrhoeae Antimicrobial Resistance at a Sexually Transmitted Diseases Clinic
Prevalence of Neisseria gonorrhoeae Antimicrobial Resistance at a Sexually Transmitted Diseases Clinic Open
View article: Impact of the BioFire® FilmArray Gastrointestinal Panel in Children Hospitalized for Acute Gastroenteritis
Impact of the BioFire® FilmArray Gastrointestinal Panel in Children Hospitalized for Acute Gastroenteritis Open
View article: Evaluation of Two Multiplex Molecular Gastrointestinal Panels Using Rectal Swab Specimens Versus Cary-Blair Stool in Pediatric Patients With Acute Gastroenteritis
Evaluation of Two Multiplex Molecular Gastrointestinal Panels Using Rectal Swab Specimens Versus Cary-Blair Stool in Pediatric Patients With Acute Gastroenteritis Open
View article: Multicenter Evaluation of the BioFire FilmArray Gastrointestinal Panel for Etiologic Diagnosis of Infectious Gastroenteritis
Multicenter Evaluation of the BioFire FilmArray Gastrointestinal Panel for Etiologic Diagnosis of Infectious Gastroenteritis Open
The appropriate treatment and control of infectious gastroenteritis depend on the ability to rapidly detect the wide range of etiologic agents associated with the disease. Clinical laboratories currently utilize an array of different metho…
View article: Use of a Culture-Independent Gastrointestinal Multiplex PCR Panel during a Shigellosis Outbreak: Considerations for Clinical Laboratories and Public Health
Use of a Culture-Independent Gastrointestinal Multiplex PCR Panel during a Shigellosis Outbreak: Considerations for Clinical Laboratories and Public Health Open
Shigella is estimated to cause nearly 500,000 infections annually in the United States ([1][1]). This estimate for the nationally notifiable disease is much higher than the actual 7,746 laboratory-confirmed cases of Shigella reported to th…