Kimberly A. Walker
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View article: The acquisition of <i>rmpADC</i> can increase virulence of classical <i>Klebsiella pneumoniae</i> in the absence of other hypervirulence-associated genes
The acquisition of <i>rmpADC</i> can increase virulence of classical <i>Klebsiella pneumoniae</i> in the absence of other hypervirulence-associated genes Open
Klebsiella pneumoniae is one of the most common causes of nosocomial infections, and the rise of drug-resistant K. pneumoniae strains is complicating treatment and contributing to a mounting global health crisis. K. pneumoniae has two path…
View article: Genomic and functional analysis of rmp locus variants in Klebsiella pneumoniae
Genomic and functional analysis of rmp locus variants in Klebsiella pneumoniae Open
View article: Klebsiella pneumoniae employs a type VI secretion system to overcome microbiota-mediated colonization resistance
Klebsiella pneumoniae employs a type VI secretion system to overcome microbiota-mediated colonization resistance Open
Microbial species must compete for space and nutrients to persist in the gastrointestinal (GI) tract, and our understanding of the complex pathobiont-microbiota interactions is far from complete. Klebsiella pneumoniae, a problematic, often…
View article: Pollen Partners: The Symbiotic Microbes of<i>Pinus radiata</i>Pollen
Pollen Partners: The Symbiotic Microbes of<i>Pinus radiata</i>Pollen Open
Pollen, a crucial source of nutrients and energy for pollinators. It also provides a unique habitat for ecological microbiota. Previous research on the microbiome of pollen has largely focussed on angiosperm systems, with limited research …
View article: Genomic and functional analysis of<i>rmp</i>locus variants in<i>Klebsiella pneumoniae</i>
Genomic and functional analysis of<i>rmp</i>locus variants in<i>Klebsiella pneumoniae</i> Open
Background Klebsiella pneumoniae is an opportunistic pathogen and a leading cause of healthcare-associated infections in hospitals, which are frequently antimicrobial resistant (AMR). Exacerbating the public health threat posed by K. pneum…
View article: Feasibility of a community-based structured exercise program for persons with spinal cord injury
Feasibility of a community-based structured exercise program for persons with spinal cord injury Open
The EG had improvements in the two primary measures, cardiorespiratory fitness and musculoskeletal strength, following the intervention. The community-based exercise intervention was feasible and accepted by participants.
View article: Colistin resistance mutations in phoQ can sensitize Klebsiella pneumoniae to IgM-mediated complement killing
Colistin resistance mutations in phoQ can sensitize Klebsiella pneumoniae to IgM-mediated complement killing Open
View article: Hypermucoviscosity Regulator RmpD Interacts with Wzc and Controls Capsular Polysaccharide Chain Length
Hypermucoviscosity Regulator RmpD Interacts with Wzc and Controls Capsular Polysaccharide Chain Length Open
Infections caused by Klebsiella pneumoniae continue to be a global public health threat; the treatment of these infections is complicated by the high frequency of multidrug resistance. K. pneumoniae produces a polysaccharide capsule requir…
View article: Colistin resistance mutations in <i>phoQ</i> sensitize <i>Klebsiella pneumoniae</i> to IgM-mediated complement killing
Colistin resistance mutations in <i>phoQ</i> sensitize <i>Klebsiella pneumoniae</i> to IgM-mediated complement killing Open
The Gram-negative bacterium Klebsiella pneumoniae is notorious for a strong increase of infections with antibiotic resistant strains. To treat infections with antibiotic resistant K. pneumoniae, clinicians increasingly need to use the last…
View article: Genome Sequence of <i>Dermacoccus</i> Strain Tok2021, a Soil Actinobacterium Isolated from a Pinus radiata Forest
Genome Sequence of <i>Dermacoccus</i> Strain Tok2021, a Soil Actinobacterium Isolated from a Pinus radiata Forest Open
Dermacoccus strain Tok2021 ( Actinobacteria ) is a soil bacterium, isolated from commercial Pinus radiata forest soil from Tokoiti, New Zealand. The bacterium has a draft genome size of 3,101,786 bp and harbors genes involved in antibiotic…
View article: Community-based exercise goals of persons with spinal cord injury: Interpreted using the International Classification of Functioning, Disability, and Health
Community-based exercise goals of persons with spinal cord injury: Interpreted using the International Classification of Functioning, Disability, and Health Open
PwSCI have goals they would like to achieve through participation in exercise. The goals are multifaceted and encompass improving health and fitness as well as improving performance in everyday activities such as transferring and mobility.…
View article: Novel Drivers of Virulence in Clostridioides difficile Identified via Context-Specific Metabolic Network Analysis
Novel Drivers of Virulence in Clostridioides difficile Identified via Context-Specific Metabolic Network Analysis Open
Clostridioides difficile has become the leading single cause of hospital-acquired infections. Numerous studies have demonstrated the importance of specific metabolic pathways in aspects of C. difficile pathophysiology, from initial coloniz…
View article: Conserved Virulence-Linked Metabolic Reprogramming in <i>Clostridioides Difficile</i> Identified Through Genome-Scale Metabolic Network Analysis
Conserved Virulence-Linked Metabolic Reprogramming in <i>Clostridioides Difficile</i> Identified Through Genome-Scale Metabolic Network Analysis Open
View article: Novel drivers of virulence in<i>Clostridioides difficile</i>identified via context-specific metabolic network analysis
Novel drivers of virulence in<i>Clostridioides difficile</i>identified via context-specific metabolic network analysis Open
The pathogen Clostridioides difficile causes toxin-mediated diarrhea and is the leading cause of hospital-acquired infection in the US. Due to growing antibiotic resistance and recurrent infection, targeting C. difficile metabolism present…
View article: A Phenotype at Last: Essential Role for the Yersinia enterocolitica Ysa Type III Secretion System in a Drosophila melanogaster S2 Cell Model
A Phenotype at Last: Essential Role for the Yersinia enterocolitica Ysa Type III Secretion System in a Drosophila melanogaster S2 Cell Model Open
The highly pathogenic Yersinia enterocolitica strains have a chromosomally encoded type III secretion system (T3SS) that is expressed and functional in vitro only when the bacteria are cultured at 26°C. Mutations that render this system no…
View article: The Small Protein RmpD Drives Hypermucoviscosity in Klebsiella pneumoniae
The Small Protein RmpD Drives Hypermucoviscosity in Klebsiella pneumoniae Open
Capsule is a critical virulence factor in Klebsiella pneumoniae , in both antibiotic-resistant classical strains and hypervirulent strains. Hypervirulent strains usually have a hypermucoviscosity (HMV) phenotype that contributes to their h…
View article: The YsrS Paralog DygS Has the Capacity To Activate Expression of the Yersinia enterocolitica Ysa Type III Secretion System
The YsrS Paralog DygS Has the Capacity To Activate Expression of the Yersinia enterocolitica Ysa Type III Secretion System Open
The Yersinia enterocolitica Ysa type III secretion system (T3SS) is associated with intracellular survival, and, like other characterized T3SSs, it is tightly controlled. Expression of the ysa genes is only detected following growth at low…
View article: A Serendipitous Mutation Reveals the Severe Virulence Defect of a Klebsiella pneumoniae fepB Mutant
A Serendipitous Mutation Reveals the Severe Virulence Defect of a Klebsiella pneumoniae fepB Mutant Open
Klebsiella pneumoniae is considered a significant public health threat because of the emergence of multidrug-resistant strains and the challenge associated with treating life-threatening infections. Capsule, siderophores, and adhesins have…
View article: The intersection of capsule gene expression, hypermucoviscosity and hypervirulence in Klebsiella pneumoniae
The intersection of capsule gene expression, hypermucoviscosity and hypervirulence in Klebsiella pneumoniae Open
View article: The small protein RmpD drives hypermucoviscosity in<i>Klebsiella pneumoniae</i>
The small protein RmpD drives hypermucoviscosity in<i>Klebsiella pneumoniae</i> Open
Klebsiella pneumoniae has a remarkable ability to cause a wide range of human diseases. It is divided into two broad classes: Classical strains that are a notable problem in healthcare settings due to multidrug resistance, and hypervirulen…
View article: A Klebsiella pneumoniae Regulatory Mutant Has Reduced Capsule Expression but Retains Hypermucoviscosity
A Klebsiella pneumoniae Regulatory Mutant Has Reduced Capsule Expression but Retains Hypermucoviscosity Open
Klebsiella pneumoniae continues to be a substantial public health threat due to its ability to cause health care-associated and community-acquired infections combined with its ability to acquire antibiotic resistance. Novel therapeutics ar…
View article: Identification of Two Regulators of Virulence That Are Conserved in <i>Klebsiella pneumoniae</i> Classical and Hypervirulent Strains
Identification of Two Regulators of Virulence That Are Conserved in <i>Klebsiella pneumoniae</i> Classical and Hypervirulent Strains Open
Klebsiella pneumoniae is widely recognized as a pathogen with a propensity for acquiring antibiotic resistance. It is capable of causing a range of hospital-acquired infections (urinary tract infections [UTI], pneumonia, sepsis) and commun…
View article: A Serendipitous Mutation Reveals the Severe Virulence Defect of a Klebsiella pneumoniae <i>fepB</i> Mutant
A Serendipitous Mutation Reveals the Severe Virulence Defect of a Klebsiella pneumoniae <i>fepB</i> Mutant Open
In addition to having a reputation as the causative agent of several types of hospital-acquired infections, Klebsiella pneumoniae has gained widespread attention as a pathogen with a propensity for acquiring antibiotic resistance. It is ca…
View article: The YsrS Paralog DygS Has the Capacity To Activate Expression of the Yersinia enterocolitica Ysa Type III Secretion System
The YsrS Paralog DygS Has the Capacity To Activate Expression of the Yersinia enterocolitica Ysa Type III Secretion System Open
The Yersinia enterocolitica Ysa type III secretion system (T3SS) is associated with intracellular survival, and, like other characterized T3SSs, it is tightly controlled. Expression of the ysa genes is only detected following growth at low…
View article: Leveraging Online Curricula for Antimicrobial Stewardship: Training Providers to Optimize Therapy With Antibiotic Timeouts
Leveraging Online Curricula for Antimicrobial Stewardship: Training Providers to Optimize Therapy With Antibiotic Timeouts Open
View article: A Strategic Approach to Implementation of Medical Mentorship Programs
A Strategic Approach to Implementation of Medical Mentorship Programs Open
Background Mentors influence medical trainees' experiences through career enhancement and psychosocial support, yet some trainees never receive benefits from involved mentors. Objective Our goals were to examine the effectiveness of 2 inte…