Kimberly J. Jenko
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View article: Neuroinflammation in frontotemporal lobar degeneration revealed by <sup>11</sup>C‐PBR28 PET
Neuroinflammation in frontotemporal lobar degeneration revealed by <sup>11</sup>C‐PBR28 PET Open
This study used 11 C‐PBR28 positron emission tomography (PET) imaging to determine whether levels of 18‐kDa translocator protein (TSPO), an inflammation‐specific biomarker, are increased in frontotemporal lobar degeneration (FTLD) patients…
View article: Subanesthetic IV ketamine reduces acute suicidal ideation in patients with mood disorders
Subanesthetic IV ketamine reduces acute suicidal ideation in patients with mood disorders Open
Background. Depression and suicide are common in the United States and present a significant problem in the healthcare landscape. Currently, there are few options that can rapidly reduce suicidal ideation in patients with depression. Ketam…
View article: 2-(4-Methylsulfonylphenyl)pyrimidines as Prospective Radioligands for Imaging Cyclooxygenase-2 with PET—Synthesis, Triage, and Radiolabeling
2-(4-Methylsulfonylphenyl)pyrimidines as Prospective Radioligands for Imaging Cyclooxygenase-2 with PET—Synthesis, Triage, and Radiolabeling Open
Cyclooxygenase 2 (COX-2) is an inducible enzyme responsible for the conversion of arachidonic acid into the prostaglandins, PGG2 and PGH2. Expression of this enzyme increases in inflammation. Therefore, the development of probes for imagin…
View article: 3-Substituted 1,5-Diaryl-1<i>H</i>-1,2,4-triazoles as Prospective PET Radioligands for Imaging Brain COX-1 in Monkey. Part 2: Selection and Evaluation of [<sup>11</sup>C]PS13 for Quantitative Imaging
3-Substituted 1,5-Diaryl-1<i>H</i>-1,2,4-triazoles as Prospective PET Radioligands for Imaging Brain COX-1 in Monkey. Part 2: Selection and Evaluation of [<sup>11</sup>C]PS13 for Quantitative Imaging Open
In our preceding paper (Part 1), we identified three 1,5-bis-diaryl-1,2,4-triazole-based compounds that merited evaluation as potential positron emission tomography (PET) radioligands for selectively imaging cyclooxygenase-1 (COX-1) in mon…
View article: 3-Substituted 1,5-Diaryl-1<i>H</i>-1,2,4-triazoles as Prospective PET Radioligands for Imaging Brain COX-1 in Monkey. Part 1: Synthesis and Pharmacology
3-Substituted 1,5-Diaryl-1<i>H</i>-1,2,4-triazoles as Prospective PET Radioligands for Imaging Brain COX-1 in Monkey. Part 1: Synthesis and Pharmacology Open
Cyclooxygenase-1 (COX-1) is a key enzyme in the biosynthesis of proinflammatory thromboxanes and prostaglandins and is found in glial and neuronal cells within brain. COX-1 expression is implicated in numerous neuroinflammatory states. We …
View article: Distinct patterns of increased translocator protein in posterior cortical atrophy and amnestic Alzheimer's disease
Distinct patterns of increased translocator protein in posterior cortical atrophy and amnestic Alzheimer's disease Open
View article: The 5-HT<sub>1A</sub>Receptor PET Radioligand<sup>11</sup>C-CUMI-101 Has Significant Binding to α<sub>1</sub>-Adrenoceptors in Human Cerebellum, Limiting Its Use as a Reference Region
The 5-HT<sub>1A</sub>Receptor PET Radioligand<sup>11</sup>C-CUMI-101 Has Significant Binding to α<sub>1</sub>-Adrenoceptors in Human Cerebellum, Limiting Its Use as a Reference Region Open
Reasoning by analogy, 25% of 11C-CUMI-101 uptake in human cerebellum reflects binding to α1-adrenoceptors, suggesting that the cerebellum is of limited usefulness as a reference tissue for quantification in human stud…
View article: Translocator protein ligands based on N -methyl-(quinolin-4-yl)oxypropanamides with properties suitable for PET radioligand development
Translocator protein ligands based on N -methyl-(quinolin-4-yl)oxypropanamides with properties suitable for PET radioligand development Open
View article: 11C-PBR28 binding to translocator protein increases with progression of Alzheimer's disease
11C-PBR28 binding to translocator protein increases with progression of Alzheimer's disease Open
View article: [ carbonyl - 11 C]4-Fluoro- N -methyl- N -(4-(6-(methylamino)pyrimidin-4-yl)thiazol-2-yl)benzamide ([ 11 C]FIMX) is an effective radioligand for PET imaging of metabotropic glutamate receptor 1 (mGluR1) in monkey brain
[ carbonyl - 11 C]4-Fluoro- N -methyl- N -(4-(6-(methylamino)pyrimidin-4-yl)thiazol-2-yl)benzamide ([ 11 C]FIMX) is an effective radioligand for PET imaging of metabotropic glutamate receptor 1 (mGluR1) in monkey brain Open
View article: IC‐P‐090: Increased radioligand binding to translocator protein correlates with worsened clinical severity and atrophy in Alzheimer's disease
IC‐P‐090: Increased radioligand binding to translocator protein correlates with worsened clinical severity and atrophy in Alzheimer's disease Open
We previously demonstrated that radioligand binding to the 18 kDa translocator protein (TSPO), a marker for inflammation, was greater in patients with Alzheimer's disease (AD) than controls and correlated with clinical severity. We sought …
View article: Neuroinflammation in Temporal Lobe Epilepsy Measured Using Positron Emission Tomographic Imaging of Translocator Protein
Neuroinflammation in Temporal Lobe Epilepsy Measured Using Positron Emission Tomographic Imaging of Translocator Protein Open
Binding of TSPO is increased both ipsilateral and contralateral to seizure foci in patients with TLE, suggesting ongoing inflammation. Anti-inflammatory therapy may play a role in treating drug-resistant epilepsy.