Explanipedia

Transcriptional Integration of Meiotic Prophase I Progression and Early Oocyte Differentiation Open

Kimberly M. Abt, Myles A. Bartholomew, Alan J. Nixon, Hanna E. Richman, Megan A. Gura , et al. · 2025

Female reproductive senescence results from the regulated depletion of a finite pool of oocytes called the ovarian reserve. This pool of oocytes is initially established during fetal development, but the oocytes that comprise it must remai…

Transcription and chromatin regulation by TAF4b during cellular quiescence of developing prospermatogonia Open

Megan A. Gura, Myles A. Bartholomew, Kimberly M. Abt, Soňa Relovská, Kimberly A. Seymour , et al. · 2023

Prospermatogonia (ProSpg) link the embryonic development of male primordial germ cells to the healthy establishment of postnatal spermatogonia and spermatogonial stem cells. While these spermatogenic precursor cells undergo the characteris…

TAF4b Transcriptional Regulation During Cellular Quiescence of Developing Prospermatogonia Open

Megan A. Gura, Myles A. Bartholomew, Kimberly M. Abt, Soňa Relovská, Kimberly A. Seymour , et al. · 2022

Prospermatogonia (ProSpg) link the embryonic development of male primordial germ cells to the healthy establishment of postnatal spermatogonia and long-term mammalian spermatogenesis. While these spermatogenic precursor cells undergo the c…

TAF4b transcription networks regulating early oocyte differentiation Open

Megan A. Gura, Soňa Relovská, Kimberly M. Abt, Kimberly A. Seymour, Tong Wu , et al. · 2022

Establishment of a healthy ovarian reserve is contingent upon numerous regulatory pathways during embryogenesis. Previously, mice lacking TBP-associated factor 4b (Taf4b) were shown to exhibit a diminished ovarian reserve. However, potenti…

TAF4b transcription networks regulating early oocyte differentiation Open

Megan A. Gura, Soňa Relovská, Kimberly M. Abt, Kimberly A. Seymour, Tong Wu , et al. · 2021

Establishment of a healthy ovarian reserve is contingent upon numerous regulatory pathways during embryogenesis. Previously, mice lacking TBP-associated factor 4b ( Taf4b ) were shown to exhibit a diminished ovarian reserve. However, poten…

Amyloid Beta and Tau Cooperate to Cause Reversible Behavioral and Transcriptional Deficits in a Model of Alzheimer’s Disease Open

Eleanor K. Pickett, Abigail G. Herrmann, Jamie McQueen, Kimberly M. Abt, Owen Dando , et al. · 2019

A key knowledge gap blocking development of effective therapeutics for Alzheimer's disease (AD) is the lack of understanding of how amyloid beta (Aβ) peptide and pathological forms of the tau protein cooperate in causing disease phenotypes…

Reducing tau ameliorates behavioural and transcriptional deficits in a novel model of Alzheimer’s disease Open

Eleanor K. Pickett, Abigail G. Herrmann, Jamie McQueen, Kimberly M. Abt, Owen Dando , et al. · 2018

Summary One of the key knowledge gaps blocking development of effective therapeutics for Alzheimer’s disease (AD) is the lack of understanding of how amyloid beta (Aβ) and tau cooperate in causing disease phenotypes. Within a mouse tau def…

Reducing Tau Ameliorates Behavioural and Transcriptional Deficits in a Novel Model of Alzheimer's Disease Open

Eleanor K. Pickett, Abigail G. Herrmann, Jamie McQueen, Kimberly M. Abt, Owen Dando , et al. · 2018

Characterizing Nab2 Phosphorylation and its Role in Regulating Egr Transcription Factors Open

Kimberly M. Abt · 2018

The early growth response (Egr) family of transcription factors is composed of four members Egr1-4, which play roles in various cell behaviors including proliferation, apoptosis, and differentiation in a cell type and stimulus specific man…

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