Kimberly Ogle
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View article: Divergent B-cell and cytotoxic TNK cell activation signatures in HLA-B27-associated ankylosing spondylitis and acute anterior uveitis
Divergent B-cell and cytotoxic TNK cell activation signatures in HLA-B27-associated ankylosing spondylitis and acute anterior uveitis Open
Ankylosing spondylitis (AS), also known as radiographic axial spondyloarthritis (r-axSpA), is an immune-mediated inflammatory disorder frequently associated with acute anterior uveitis (AAU). Both conditions share a strong association with…
View article: Cellular indexing of transcriptomes and epitopes by sequencing (CITE-Seq) of peripheral blood to dissect the effect of different spondyloarthropathies
Cellular indexing of transcriptomes and epitopes by sequencing (CITE-Seq) of peripheral blood to dissect the effect of different spondyloarthropathies Open
Spondyloarthritis is a family of immune mediated inflammatory disorders with overlapping articular and extraarticular clinical manifestations and a strong association to human leukocyte antigen (HLA)-B27. Despite a strong association of HL…
View article: Axial spondyloarthritis patients have altered mucosal IgA response to oral and fecal microbiota
Axial spondyloarthritis patients have altered mucosal IgA response to oral and fecal microbiota Open
Axial spondyloarthritis (axSpA) is an inflammatory arthritis involving the spine and the sacroiliac joint with extra-articular manifestations in the eye, gut, and skin. The intestinal microbiota has been implicated as a central environment…
View article: The Interplay Between COVID-19 and Spondyloarthritis or Its Treatment
The Interplay Between COVID-19 and Spondyloarthritis or Its Treatment Open
Objective The coronavirus disease 2019 (COVID-19) pandemic has created multiple uncertainties regarding rheumatic diseases or their treatment, with regard to the susceptibility to or severity of the viral disease. We aimed to address these…
View article: Axial spondyloarthritis patients have altered mucosal IgA response to oral and fecal microbiota
Axial spondyloarthritis patients have altered mucosal IgA response to oral and fecal microbiota Open
Objective To investigate whether axial spondyloarthritis (AxSpA) patients have an altered immunoglobulin A (IgA) response in the gut and oral microbial communities. Methods We performed 16S rRNA gene (16S) sequencing on IgA positive (IgA +…
View article: HLA-B27 is associated with reduced disease activity in axial spondyloarthritis
HLA-B27 is associated with reduced disease activity in axial spondyloarthritis Open
HLA-B27 is associated with increased susceptibility and disease activity of ankylosing spondylitis, but the effect of HLA-B27 on the activity of the broader category now called axial spondyloarthritis (AxSpA) is apparently the opposite. A …
View article: Tofacitinib as a Steroid-Sparing Therapy in Pulmonary Sarcoidosis, An Open-Label Prospective Proof-of-Concept Study
Tofacitinib as a Steroid-Sparing Therapy in Pulmonary Sarcoidosis, An Open-Label Prospective Proof-of-Concept Study Open
This is a prospective, open-label, proof-of-concept study of tofacitinib, a Janus kinase inhibitor, as a steroid sparing therapy in corticosteroid-dependent pulmonary sarcoidosis. 5 patients with corticosteroid-dependent pulmonary sarcoido…
View article: Radiologic imaging shows variable accuracy in diagnosing orbital inflammatory disease and assessing its activity
Radiologic imaging shows variable accuracy in diagnosing orbital inflammatory disease and assessing its activity Open
Radiologic orbital imaging provides important information in the diagnosis and management of orbital inflammation. However, the diagnostic value of orbital imaging is not well elucidated. This study aimed to investigate the diagnostic accu…
View article: RNA-Seq of human whole blood: Evaluation of globin RNA depletion on Ribo-Zero library method
RNA-Seq of human whole blood: Evaluation of globin RNA depletion on Ribo-Zero library method Open
Peripheral blood is a highly accessible biofluid providing a rich source of information about human physiology and health status. However, for studies of the blood transcriptome with RNA sequencing (RNA-Seq) techniques, high levels of hemo…