Kimberly S. Quayle
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View article: Opioid Administration and Reduction of Pediatric Ileocolic Intussusception
Opioid Administration and Reduction of Pediatric Ileocolic Intussusception Open
Importance Ileocolic intussusception is an important and painful cause of bowel obstruction in children. Its reduction is also painful, but neither sedation nor analgesia is routinely provided, in part due to concerns surrounding gastroint…
View article: Rehydration Rates and Outcomes in Overweight Children With Diabetic Ketoacidosis
Rehydration Rates and Outcomes in Overweight Children With Diabetic Ketoacidosis Open
BACKGROUND AND OBJECTIVES The Pediatric Emergency Care Applied Research Network Fluid Therapies Under Investigation in Diabetic Ketoacidosis (DKA) (FLUID) Trial found that rapid fluid infusion does not increase the risk of cerebral injury.…
View article: Stratification of risk for emergent intracranial abnormalities in children with headaches: a Pediatric Emergency Care Applied Research Network (PECARN) study protocol
Stratification of risk for emergent intracranial abnormalities in children with headaches: a Pediatric Emergency Care Applied Research Network (PECARN) study protocol Open
Introduction Headache is a common chief complaint of children presenting to emergency departments (EDs). Approximately 0.5%–1% will have emergent intracranial abnormalities (EIAs) such as brain tumours or strokes. However, more than one-th…
View article: Radiographic pneumonia in young febrile infants presenting to the emergency department: secondary analysis of a prospective cohort study
Radiographic pneumonia in young febrile infants presenting to the emergency department: secondary analysis of a prospective cohort study Open
Objective The lack of evidence-based criteria to guide chest radiograph (CXR) use in young febrile infants results in variation in its use with resultant suboptimal quality of care. We sought to describe the features associated with radiog…
View article: Emergency Department Presentations of Diabetic Ketoacidosis in a Large Cohort of Children
Emergency Department Presentations of Diabetic Ketoacidosis in a Large Cohort of Children Open
Background. Diabetic ketoacidosis (DKA) is a potentially life-threatening complication of childhood diabetes. However, the influence of demographic factors on presentation are not well-defined. Methods. We included children from 12 centers…
View article: Sedation and Analgesia for Reduction of Pediatric Ileocolic Intussusception
Sedation and Analgesia for Reduction of Pediatric Ileocolic Intussusception Open
Importance Ileocolic intussusception is an important cause of intestinal obstruction in children. Reduction of ileocolic intussusception using air or fluid enema is the standard of care. This likely distressing procedure is usually perform…
View article: Clinical and Laboratory Predictors of Dehydration Severity in Children With Diabetic Ketoacidosis
Clinical and Laboratory Predictors of Dehydration Severity in Children With Diabetic Ketoacidosis Open
Most children with DKA have mild-to-moderate dehydration. Although biochemical measures were more closely associated with the severity of dehydration than clinical assessments, neither were sufficiently predictive to inform rehydration pra…
View article: Cognitive function following diabetic ketoacidosis in young children with type 1 diabetes
Cognitive function following diabetic ketoacidosis in young children with type 1 diabetes Open
Introduction Young children with type 1 diabetes (T1D) may be at particularly high risk of cognitive decline following diabetic ketoacidosis (DKA). However, studies of cognitive functioning in T1D typically examine school‐age children. The…
View article: Relationships among biochemical measures in children with diabetic ketoacidosis
Relationships among biochemical measures in children with diabetic ketoacidosis Open
Objectives Investigating empirical relationships among laboratory measures in children with diabetic ketoacidosis (DKA) can provide insights into physiological alterations occurring during DKA. We determined whether alterations in laborato…
View article: Serious Bacterial Infections in Young Febrile Infants With Positive Urinalysis Results
Serious Bacterial Infections in Young Febrile Infants With Positive Urinalysis Results Open
It is unknown whether febrile infants 29 to 60 days old with positive urinalysis results require routine lumbar punctures for evaluation of bacterial meningitis. OBJECTIVE To determine the prevalence of bacteremia and/or bacterial meningit…
View article: Clinical Characteristics of Children with Cerebral Injury preceding Treatment of Diabetic Ketoacidosis
Clinical Characteristics of Children with Cerebral Injury preceding Treatment of Diabetic Ketoacidosis Open
Previous studies have identified more severe acidosis and higher blood urea nitrogen (BUN) as risk factors for cerebral injury during treatment of diabetic ketoacidosis (DKA) in children; however, cerebral injury also can occur before DKA …
View article: Effects of Fluid Rehydration Strategy on Correction of Acidosis and Electrolyte Abnormalities in Children With Diabetic Ketoacidosis
Effects of Fluid Rehydration Strategy on Correction of Acidosis and Electrolyte Abnormalities in Children With Diabetic Ketoacidosis Open
OBJECTIVE Fluid replacement to correct dehydration, acidosis, and electrolyte abnormalities is the cornerstone of treatment for diabetic ketoacidosis (DKA), but little is known about optimal fluid infusion rates and electrolyte content. Th…
View article: Effects of Fluid Rehydration Strategy on Correction of Acidosis and Electrolyte Abnormalities in Children With Diabetic Ketoacidosis
Effects of Fluid Rehydration Strategy on Correction of Acidosis and Electrolyte Abnormalities in Children With Diabetic Ketoacidosis Open
IMPORTANCE: Fluid replacement to correct dehydration, acidosis and electrolyte abnormalities is the cornerstone of treatment for diabetic ketoacidosis (DKA) but little is known about optimal fluid infusion rates and electrolyte cont…
View article: Effects of Fluid Rehydration Strategy on Correction of Acidosis and Electrolyte Abnormalities in Children With Diabetic Ketoacidosis
Effects of Fluid Rehydration Strategy on Correction of Acidosis and Electrolyte Abnormalities in Children With Diabetic Ketoacidosis Open
IMPORTANCE: Fluid replacement to correct dehydration, acidosis and electrolyte abnormalities is the cornerstone of treatment for diabetic ketoacidosis (DKA) but little is known about optimal fluid infusion rates and electrolyte cont…
View article: Frequency and Risk Factors of Acute Kidney Injury During Diabetic Ketoacidosis in Children and Association With Neurocognitive Outcomes
Frequency and Risk Factors of Acute Kidney Injury During Diabetic Ketoacidosis in Children and Association With Neurocognitive Outcomes Open
These findings suggest that AKI may occur more frequently in children with greater acidosis and circulatory volume depletion during DKA and may be part of a pattern of multiple organ injury involving the kidneys and brain.
View article: Cognitive Function following Diabetic Ketoacidosis in Children with New Onset or Previously Diagnosed Type 1 Diabetes
Cognitive Function following Diabetic Ketoacidosis in Children with New Onset or Previously Diagnosed Type 1 Diabetes Open
Objective. This study assessed whether a single diabetic ketoacidosis (DKA) episode is associated with cognitive declines in children with newly diagnosed type 1 diabetes, and whether the same is true in children who had been previo…
View article: Cognitive Function following Diabetic Ketoacidosis in Children with New Onset or Previously Diagnosed Type 1 Diabetes
Cognitive Function following Diabetic Ketoacidosis in Children with New Onset or Previously Diagnosed Type 1 Diabetes Open
Objective. This study assessed whether a single diabetic ketoacidosis (DKA) episode is associated with cognitive declines in children with newly diagnosed type 1 diabetes, and whether the same is true in children who had been previo…
View article: Cognitive Function Following Diabetic Ketoacidosis in Children With New-Onset or Previously Diagnosed Type 1 Diabetes
Cognitive Function Following Diabetic Ketoacidosis in Children With New-Onset or Previously Diagnosed Type 1 Diabetes Open
OBJECTIVE This study assessed whether a single diabetic ketoacidosis (DKA) episode is associated with cognitive declines in children with newly diagnosed type 1 diabetes and whether the same is true in children who had previously been diag…
View article: Hypertension during Diabetic Ketoacidosis in Children
Hypertension during Diabetic Ketoacidosis in Children Open
View article: Reduction of Computed Tomography Use for Pediatric Closed Head Injury Evaluation at a Nonpediatric Community Emergency Department
Reduction of Computed Tomography Use for Pediatric Closed Head Injury Evaluation at a Nonpediatric Community Emergency Department Open
Objective The purpose of this study was to determine if implementation of a Pediatric Emergency Care Applied Research Network ( PECARN )‐based Closed Head Injury Assessment Tool could safely decrease computed tomography ( CT ) use for pedi…
View article: Clinical Trial of Fluid Infusion Rates for Pediatric Diabetic Ketoacidosis
Clinical Trial of Fluid Infusion Rates for Pediatric Diabetic Ketoacidosis Open
Neither the rate of administration nor the sodium chloride content of intravenous fluids significantly influenced neurologic outcomes in children with diabetic ketoacidosis. (Funded by the Eunice Kennedy Shriver National Institute of Child…
View article: Challenges Enrolling Children Into Traumatic Brain Injury Trials: An Observational Study
Challenges Enrolling Children Into Traumatic Brain Injury Trials: An Observational Study Open
Objectives In preparation for a clinical trial of therapeutic agents for children with moderate‐to‐severe blunt traumatic brain injuries ( TBI s) in emergency departments ( ED s), we conducted this feasibility study to (1) determine the nu…
View article: Circulating matrix metalloproteinases in children with diabetic ketoacidosis
Circulating matrix metalloproteinases in children with diabetic ketoacidosis Open
Circulating MMP-2 levels are lower and MMP-9 levels are higher in children during DKA compared with levels in children with diabetes without DKA. Alterations in MMP expression could mediate BBB dysfunction occurring during DKA.
View article: Comparison of Prediction Rules and Clinician Suspicion for Identifying Children With Clinically Important Brain Injuries After Blunt Head Trauma
Comparison of Prediction Rules and Clinician Suspicion for Identifying Children With Clinically Important Brain Injuries After Blunt Head Trauma Open
Objective Children with minor head trauma frequently present to emergency departments (EDs). Identifying those with traumatic brain injuries (TBIs) can be difficult, and it is unknown whether clinical prediction rules outperform clinician …