King Lam Hui
YOU?
Author Swipe
View article: DHRS7 Integrates NADP<sup>+</sup>/NADPH Redox Sensing with Inflammatory Lipid Signalling via the Oxoeicosanoid Pathway
DHRS7 Integrates NADP<sup>+</sup>/NADPH Redox Sensing with Inflammatory Lipid Signalling via the Oxoeicosanoid Pathway Open
During the innate immune response at epithelial wound sites, oxidative stress acts microbicidal and—mechanistically less well understood—as an immune and resilience signal. The reversible sulfhydryl (SH) oxidation of kinases, phosphatases,…
View article: Investigating Enzymatic Control of Inflammation Oxo-eicosanoid Synthesis in Live Zebrafish
Investigating Enzymatic Control of Inflammation Oxo-eicosanoid Synthesis in Live Zebrafish Open
Eicosanoids, derived from arachidonic acid (AA), are bioactive lipids with chemokine-like function. While prostaglandin and leukotriene have been extensively studied, the genetics of oxoeicosanoid metabolism remain relatively unexplored. T…
View article: Oxoeicosanoid signaling mediates early antimicrobial defense in zebrafish
Oxoeicosanoid signaling mediates early antimicrobial defense in zebrafish Open
5-oxoETE is a bioactive lipid derived from arachidonic acid generated when phospholipase A2 activation coincides with oxidative stress. Through its G protein-coupled receptor OXER1, pure 5-oxoETE is a potent leukocyte chemoattractant. Yet,…
View article: A synergy between mechanosensitive calcium- and membrane-binding mediates tension-sensing by C2-like domains
A synergy between mechanosensitive calcium- and membrane-binding mediates tension-sensing by C2-like domains Open
Significance A cell must be able to measure whether the lipid membranes that surround its insides are stretched. Currently, mechanosensitive ion channels are the best-studied class of membrane tension sensors, but recent work suggests that…
View article: Dynamic microtubules regulate cellular contractility during T-cell activation
Dynamic microtubules regulate cellular contractility during T-cell activation Open
Significance T-cell activation is an essential event in the adaptive immune response to fight against infections. T cells were recently shown to be mechanosensitive, and to exert forces actively on the opposing antigen-presenting cell duri…