Kinga Ostrowska
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View article: SYNTHESIS OF 7-(2,3-EPOXYPROPOXY)COUMARIN DERIVATIVES AND EVALUATION OF THEIR RADICAL-SCAVENGING PROPERTIES BY EPR SPECTROSCOPY
SYNTHESIS OF 7-(2,3-EPOXYPROPOXY)COUMARIN DERIVATIVES AND EVALUATION OF THEIR RADICAL-SCAVENGING PROPERTIES BY EPR SPECTROSCOPY Open
Coumarin derivatives are known for their broad biological activities, particularly their ability to influence oxidative stress pathways. In this work, a new series of 7-(2,3-epoxypropoxy)coumarin derivatives were synthesized and fully char…
View article: Coumarin–Dithiocarbamate Derivatives as Biological Agents
Coumarin–Dithiocarbamate Derivatives as Biological Agents Open
Coumarin derivatives, whether natural or synthetic, have attracted considerable interest from medicinal chemists due to their versatile biological properties. Their appealing pharmacological activities—such as anticancer, anti-inflammatory…
View article: Exploring the Potential of Coumarin Derivatives on Serotonin Receptors 5-HT1A and 5HT2A
Exploring the Potential of Coumarin Derivatives on Serotonin Receptors 5-HT1A and 5HT2A Open
A series of 2- and 3-methoxyphenylpiperazine derivatives in combination with a 2-hydroxypropoxy linker and coumarins containing various substituents was synthesized and evaluated for antidepressant-like activity. Microwave-assisted synthes…
View article: Coumarin Derivative Hybrids: Novel Dual Inhibitors Targeting Acetylcholinesterase and Monoamine Oxidases for Alzheimer’s Therapy
Coumarin Derivative Hybrids: Novel Dual Inhibitors Targeting Acetylcholinesterase and Monoamine Oxidases for Alzheimer’s Therapy Open
Multi-target-directed ligands (MTDLs) represent a promising frontier in tackling the complexity of multifactorial pathologies like Alzheimer’s disease (AD). The synergistic inhibition of MAO-B, MAO-A, and AChE is believed to enhance treatm…
View article: CCDC 2213451: Experimental Crystal Structure Determination
CCDC 2213451: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Synthesis, Biological Activity, ADME and Molecular Docking Studies of Novel Ursolic Acid Derivatives as Potent Anticancer Agents
Synthesis, Biological Activity, ADME and Molecular Docking Studies of Novel Ursolic Acid Derivatives as Potent Anticancer Agents Open
A series of new ursolic acid (UA) derivatives substituted with various amino acids (AAs) or dipeptides (DP) at the C-3 position of the steroid skeleton was designed and synthesized. The compounds were obtained by the esterification of UA w…
View article: New Piperazine Derivatives of 6-Acetyl-7-hydroxy-4-methylcoumarin as 5-HT1A Receptor Agents
New Piperazine Derivatives of 6-Acetyl-7-hydroxy-4-methylcoumarin as 5-HT1A Receptor Agents Open
A series of 15 new derivatives of 6-acetyl-7-hydroxy-4-methylcoumarin containing a piperazine group were designed with the help of computational methods and were synthesized to study their affinity for the serotonin 5-HT1A and 5-HT2A recep…
View article: Design, Synthesis, and Biological Evaluation of a Series of 5- and 7-Hydroxycoumarin Derivatives as 5-HT1A Serotonin Receptor Antagonists
Design, Synthesis, and Biological Evaluation of a Series of 5- and 7-Hydroxycoumarin Derivatives as 5-HT1A Serotonin Receptor Antagonists Open
We have designed and synthesized a series of 60 new 5- and 7-hydroxycoumarin derivatives bearing the piperazine moiety with the expected binding to 5-HT1A and 5-HT2A receptors. Molecular docking of all investigated compounds revealed subna…
View article: CCDC 1854982: Experimental Crystal Structure Determination
CCDC 1854982: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1542353: Experimental Crystal Structure Determination
CCDC 1542353: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1854981: Experimental Crystal Structure Determination
CCDC 1854981: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Development of selective agents targeting serotonin 5HT<sub>1A</sub> receptors with subnanomolar activities based on a coumarin core
Development of selective agents targeting serotonin 5HT<sub>1A</sub> receptors with subnanomolar activities based on a coumarin core Open
A screening of 18 compounds identified five coumarin derivatives with subnanomolar activity against the 5HT1A receptor.
View article: CCDC 1052645: Experimental Crystal Structure Determination
CCDC 1052645: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1541420: Experimental Crystal Structure Determination
CCDC 1541420: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1032302: Experimental Crystal Structure Determination
CCDC 1032302: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1032303: Experimental Crystal Structure Determination
CCDC 1032303: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1031665: Experimental Crystal Structure Determination
CCDC 1031665: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …