Explanipedia

Chemobrain and Cancer Survivorship: A Scoping Review of the Literature Open

Michael J. Rovito, Kinsuk Chauhan, Hassan Baig · 2025

Background Cancer‐related cognitive impairment (CRCI), commonly known as chemobrain, is characterized by deficits in memory, processing speed, and executive function. While traditionally linked to chemotherapy, emerging evidence suggests t…

AI-mediated immunotherapeutics in adenoid cystic carcinoma: Challenges and current perspectives Open

Mahendra Singh, Chitra Singh, Kinsuk Chauhan, Gaurav Kumar Rajpoot, Chakresh Kumar · 2025

Adenoid Cystic Carcinoma (AdCC) is an uncommon, aggressive, and incurable head and neck cancer. Using cutting-edge machine learning (ML) and deep learning (DL) techniques, artificial intelligence (AI) has become a game-changing tool for th…

Real-world treatment patterns and management gaps of lumbar disc herniation in the United States Open

Amit K. Bhandutia, Min Yang, Qing Liu, Yubo Gao, J. Liu , et al. · 2025

In this study, approximately one quarter of patients with LDH underwent ESI and/or surgery after conservative treatment. Opportunities exist to provide more guideline-concordant care to patients with LDH. In addition, unmet needs exist in …

The High Correlation Between Survey Assessments for Chronic Kidney Disease-Associated Pruritus, and Its Associations with Clinical Outcomes Open

Huei Hsun Wen, Kinsuk Chauhan, Steven G. Coca, Juliana Ghisleni de Oliveira, Tejas Desai , et al. · 2025

Background: Chronic kidney disease-associated pruritus (CKD-aP) is a common condition in dialysis patients, and is associated with lower quality of life, depression, and sleep problems. CKD-aP is under-recognized and undertreated. While qu…

Impact of Condoliase on Health-related Quality of Life in Participants With Radicular Leg Pain Associated With Lumbar Disk Herniation Open

Kevin Macadaeg, Kee D. Kim, Pragya B Gupta, José Juan Oliva Rivera, Anand Patel , et al. · 2025

Study Design. An exploratory analysis of a randomized, double-blind, sham-controlled, phase three study. Objective. To evaluate the impact of SI-6603 (condoliase) on health-related quality of life (HRQoL)-related outcomes in patients with …

Women, Men, and Cancer Survivorship: A Commentary on Current Data and Possible Underlying Issues Open

Michael J. Rovito, Sydney A. Martinez, Kent Thomas, Kinsuk Chauhan, Samantha Gibson · 2025

Tonorezos et al.’s recent analysis of U.S. cancer survivorship prevalence provides insightful commentary on the dramatic increase of those surviving the disease over the last 50 years. This growth is reflective of improvements in cancer de…

A COMPARATIVE STUDY OF TENELIGLIPTIN VERSUS HYDROXYCHLOROQUINE AS ADD ON THERAPY IN UNCONTROLLED TYPE-II DIABETES MELLITUS PATIENTS Open

Kinsuk Chauhan, ALKA YADAV, Anurag Jain, R. K. Pal, Jitendra Doneria · 2024

Objectives: This study aimed to compare the efficacy and safety of teneligliptin versus hydroxychloroquine (HCQ) as add-on therapy in uncontrolled T2DM patients. To measure the safety and efficacy of Teneligliptin and Hydroxychloroquine as…

Treatment Gaps and Emerging Therapies in Lumbar Disc Herniation Open

Douglas P. Beall, Kee D. Kim, Kevin Macadaeg, Kianoush Donboli, Kinsuk Chauhan , et al. · 2024

BACKGROUND: Lumbar disc herniation (LDH) occurs when the central disc material, primarily the nucleus pulposus, is displaced beyond the outer annulus, compressing the spinal nerve roots. LDH symptoms, including radicular leg pain, radiculo…

Urinary Plasminogen as a Marker of Disease Progression in Human Glomerular Disease Open

Marina de Cos, Gohar Mosoyan, Kinsuk Chauhan, Jonathan P. Troost, Jenny Wong , et al. · 2024

Patient-Specific Pharmacokinetics and Dasatinib Nephrotoxicity Open

Benjamin Adegbite, Matthew Abramson, Victoria Gutgarts, Florin Marcel Musteata, Kinsuk Chauhan , et al. · 2023

Background Dasatinib has been associated with nephrotoxicity. We sought to examine the incidence of proteinuria on dasatinib and determine potential risk factors that may increase dasatinib-associated glomerular injury. Methods We examined…

Dasatinib nephrotoxicity correlates with patient-specific pharmacokinetics Open

Benjamin Adegbite, Matthew Abramson, Victoria Gutgarts, Marcel F. Musteata, Kinsuk Chauhan , et al. · 2023

A bstract Introduction Dasatinib has been associated with nephrotoxicity. We sought to examine the incidence of proteinuria on dasatinib and determine potential risk factors that may increase dasatinib-associated glomerular injury. Methods…

Higher Symptom Frequency and Severity After the Long Interdialytic Interval in Patients on Maintenance Intermittent Hemodialysis Open

Kinsuk Chauhan, Huei Hsun Wen, Neepa Gupta, Girish N. Nadkarni, Steven G. Coca , et al. · 2022

Role of time from transplantation to biopsy in histologic ABMR: A single center report Open

Jorge Rodriguez, Caroline Liu, Kinsuk Chauhan, Lisa Andersen, Cynthia Harris , et al. · 2022

Background Allograft biopsies with lesions of Antibody‐Mediated Rejection (ABMR) with Microvascular Inflammation (MVI) have shown heterogeneous etiologies and outcomes. Methods To examine factors associated with outcomes in biopsies that m…

Systematic Review and Meta-Analysis of Plasma and Urine Biomarkers for CKD Outcomes Open

Caroline Liu, Neha Debnath, Gohar Mosoyan, Kinsuk Chauhan, George Vasquez‐Rios , et al. · 2022

Background Sensitive and specific biomarkers are needed to provide better biologic insight into the risk of incident and progressive CKD. However, studies have been limited by sample size and design heterogeneity. Methods In this assessmen…

POS-322 Association of Changes in Modifiable Factors with Changes in KidneyIntelXTM Scores in the CANVAS Participants with Prevalent Diabetic Kidney Disease Open

Girish N. Nadkarni, D. Takale, Kinsuk Chauhan, Fergus Fleming, Hiddo J.L. Heerspink , et al. · 2022

KidneyIntelXTMis a composite risk score for DKD progression that incorporates clinical variables and 3 plasma biomarkers. We have previously shown that changes in KidneyIntelX are informative as a time-updated prognostic risk assessment in…

POS-189 Added Value of KidneyIntelXTM for Predicting Future Kidney Function Decline Compare to Historical eGFR Trajectories Open

Girish N. Nadkarni, Kinsuk Chauhan, Fergus Fleming, Steven G. Coca · 2022

Enrollment into clinical trials for kidney disease based on high albuminuria or low eGFR have not always yielded desired event rates. Recent data suggests that pre-trial eGFR slope may be a better tool to select trial participants. Few stu…

Table of Contents Open

Valentina Leone, Katja Peschke, M Reichert, C. Mel Wilcox, Austin L. Chiang , et al. · 2022

Prevalence and Outcomes Associated with Hyperuricemia in Hospitalized Patients with COVID-19 Open

Kinsuk Chauhan, Pattharawin Pattharanitima, Federica Piani, Richard J. Johnson, Jaime Uribarri , et al. · 2021

Introduction: Coronavirus 2019 (COVID-19) can increase catabolism and result in hyperuricemia. Uric acid (UA) potentially causes kidney damage by alteration of renal autoregulation, inhibition of endothelial cell proliferatio…

Recipient APOL1 risk alleles associate with death-censored renal allograft survival and rejection episodes Open

Zhongyang Zhang, Zeguo Sun, Qisheng Lin, Khadija Banu, Kinsuk Chauhan , et al. · 2021

Apolipoprotein L1 (APOL1) risk alleles in donor kidneys associate with graft loss but whether recipient risk allele expression impacts kidney transplant outcomes is unclear. To test whether recipient APOL1 allelic variants independently co…

Author Reply to Comment on “Assessment of Plasma Oxalate Concentration in Patients With CKD” by Oka et al. Open

Anja Pfau, Monika Wytopil, Kinsuk Chauhan, Martin Reichel, Steven G. Coca , et al. · 2021

The Author Replies: We thank Oka et al. for the precise summary of our study “Assessment of plasma oxalate concentration in patients with CKD”1Pfau A. Wytopil M. Chauhan K. et al.Assessment of plasma oxalate concentration in patients with …

Supplementary Material for: Prevalence and Outcomes Associated with Hyperuricemia in Hospitalized Patients with COVID-19 Open

Kinsuk Chauhan, Pattharawin Pattharanitima, Federica Piani, Johnson Rajeswar J, Jaime Uribarri , et al. · 2021

Introduction: Coronavirus 2019 (COVID-19) can increase catabolism and result in hyperuricemia. Uric acid (UA) potentially causes kidney damage by alteration of renal autoregulation, inhibition of endothelial cell proliferatio…

Supplementary Material for: Comparison of Approaches for Prediction of Renal Replacement Therapy-Free Survival in Patients with Acute Kidney Injury Open

Pattharawin Pattharanitima, Akhil Vaid, Suraj K. Jaladanki, Ishan Paranjpe, Ross O’Hagan , et al. · 2021

Background/Aims: Acute kidney injury (AKI) in critically ill patients is common, and continuous renal replacement therapy (CRRT) is a preferred mode of renal replacement therapy (RRT) in hemodynamically unstable patients. Pre…

Comparison of Approaches for Prediction of Renal Replacement Therapy-Free Survival in Patients with Acute Kidney Injury Open

Pattharawin Pattharanitima, Akhil Vaid, Suraj K. Jaladanki, Ishan Paranjpe, Ross O’Hagan , et al. · 2021

Background/Aims: Acute kidney injury (AKI) in critically ill patients is common, and continuous renal replacement therapy (CRRT) is a preferred mode of renal replacement therapy (RRT) in hemodynamically unstable patients. Pre…

Plasminogenuria is associated with podocyte injury, edema, and kidney dysfunction in incident glomerular disease Open

Marc A. Egerman, Jenny Wong, Runxia Tian, Gohar Mosoyan, Kinsuk Chauhan , et al. · 2020

Urinary plasminogen/plasmin, or plasmin (ogen) uria, has been demonstrated in proteinuric patients and exposure of cultured podocytes to plasminogen results in injury via oxidative stress pathways. A causative role for plasmin (ogen) as a …

Utilization of Deep Learning for Subphenotype Identification in Sepsis-Associated Acute Kidney Injury Open

Kumardeep Chaudhary, Akhil Vaid, Áine Duffy, Ishan Paranjpe, Suraj K. Jaladanki , et al. · 2020

Background and objectives Sepsis-associated AKI is a heterogeneous clinical entity. We aimed to agnostically identify sepsis-associated AKI subphenotypes using deep learning on routinely collected data in electronic health records. Design,…

Assessment of Plasma Oxalate Concentration in Patients With CKD Open

Anja Pfau, Monika Wytopil, Kinsuk Chauhan, Martin Reichel, Steven G. Coca , et al. · 2020

The association of standard Kt/V and surface <span>area‐normalized</span> standard Kt/V with clinical outcomes in hemodialysis patients Open

Pattharawin Pattharanitima, Kinsuk Chauhan, Osama El Shamy, Kumardeep Chaudhary, Shuchita Sharma , et al. · 2020

Introduction A previous study demonstrated that the surface area‐normalized standard Kt/V (SAstdKt/V) was better associated with mortality than standard Kt/V (stdKt/V). This study investigates the association of SAstdKt/V and stdKt/V with …

Initial Validation of a Machine Learning-Derived Prognostic Test (KidneyIntelX) Integrating Biomarkers and Electronic Health Record Data To Predict Longitudinal Kidney Outcomes Open

Kinsuk Chauhan, Girish N. Nadkarni, Fergus Fleming, James R. McCullough, Cijiang He , et al. · 2020

Background Individuals with type 2 diabetes (T2D) or the apolipoprotein L1 high-risk ( APOL1 -HR) genotypes are at increased risk of rapid kidney function decline (RKFD) and kidney failure. We hypothesized that a prognostic test using mach…

Acute Kidney Injury in Hospitalized Patients with COVID-19 Open

Lili Chan, Kumardeep Chaudhary, Aparna Saha, Kinsuk Chauhan, Akhil Vaid , et al. · 2020

Importance Preliminary reports indicate that acute kidney injury (AKI) is common in coronavirus disease (COVID)-19 patients and is associated with worse outcomes. AKI in hospitalized COVID-19 patients in the United States is not well-descr…

Racial and Ethnic Disparities in Pregnancy-Related Acute Kidney Injury Open

Kelly H. Beers, Huei Hsun Wen, Aparna Saha, Kinsuk Chauhan, Mihir Dave , et al. · 2020

Background Pregnancy-related AKI (PR-AKI) is increasing in the United States. PR-AKI is associated with adverse maternal outcomes. Disparities in racial/ethnic differences in PR-AKI by race have not been studied. Methods This was a retrosp…

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